pH/Glucose Dual Responsive Metformin Release Hydrogel Dressings with Adhesion and Self-Healing via Dual-Dynamic Bonding for Athletic Diabetic Foot Wound Healing

ACS Nano, Год журнала: 2022, Номер 16(2), С. 3194 - 3207

Опубликована: Янв. 31, 2022

In view of the lack a specific drug-sustained release system that is responsive to chronic wounds type II diabetic foot, and demands for frequent movement at foot wound, pH/glucose dual-responsive metformin-released adhesion-enhanced self-healing easy-removable antibacterial antioxidant conductive hemostasis multifunctional phenylboronic acid benzaldehyde bifunctional polyethylene glycol-co-poly(glycerol sebacic acid)/dihydrocaffeic l-arginine cografted chitosan (PEGS-PBA-BA/CS-DA-LAG, denoted as PC) hydrogel dressings were constructed based on double dynamic bond Schiff-base phenylboronate ester. It was further demonstrated PC promotes wound healing by reducing inflammation enhancing angiogenesis in rat model. addition, addition metformin (Met) graphene oxide (GO), well their synergy, confirmed better promote repair vivo. summary, PC/GO/Met hydrogels with stimuli-responsive ability easy removability have shown promoting effect athletic provide local-specific drug dual-response strategy treatment feet.

Язык: Английский

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Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

Advanced Healthcare Materials, Год журнала: 2020, Номер 9(5)

Опубликована: Янв. 24, 2020

Abstract The accelerating and thorough treatment of chronic wounds still represents a major unmet medical need owing to the complex symptoms resulting from metabolic disorder wound microenvironment. Although numerous strategies bioactive hydrogels are developed, an effective widely used method remains bottleneck. With aim accelerate healing, many hydrogel dressings with antioxidant functions have emerged proven especially for repair. new strategy in brought by is great significance human health. Here, application repair discussed systematically, aiming provide important theoretical reference further breakthrough healing.

Язык: Английский

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Promoting the healing of infected diabetic wound by an anti-bacterial and nano-enzyme-containing hydrogel with inflammation-suppressing, ROS-scavenging, oxygen and nitric oxide-generating properties

Biomaterials, Год журнала: 2022, Номер 286, С. 121597 - 121597

Опубликована: Май 22, 2022

Язык: Английский

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Engineering Bioactive M2 Macrophage‐Polarized Anti‐Inflammatory, Antioxidant, and Antibacterial Scaffolds for Rapid Angiogenesis and Diabetic Wound Repair

Advanced Functional Materials, Год журнала: 2021, Номер 31(30)

Опубликована: Май 26, 2021

Abstract Diabetic wound healing still faces great challenges due to the excessive inflammation, easy infection, and impaired angiogenesis in beds. The immunoregulation of macrophages polarization toward M2 phenotype that facilitates transition from inflammation proliferation phase has been proved be an effective way improve diabetic healing. Herein, phenotype‐enabled anti‐inflammatory, antioxidant, antibacterial conductive hydrogel scaffolds (GDFE) for producing rapid repair are reported. GDFE fabricated facilely through dynamic crosslinking between polypeptide polydopamine graphene oxide. possess thermosensitivity, self‐healing behavior, injectability, broad‐spectrum activity, antioxidant anti‐inflammatory ability, electronic conductivity. effectively activates significantly promotes dermal fibroblasts, migration, vitro endothelial cells paracrine mechanisms. vivo results a full‐thickness model demonstrate can rapidly promote skin regeneration, fast anti‐inflammation macrophage polarization. This study provides highly efficient strategy treating designing polarization‐enabled bioactive materials.

Язык: Английский

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Natural Polymer-Based Antimicrobial Hydrogels without Synthetic Antibiotics as Wound Dressings

Biomacromolecules, Год журнала: 2020, Номер 21(8), С. 2983 - 3006

Опубликована: Июль 16, 2020

Wound healing is usually accompanied by bacterial infection. The excessive use of synthetic antibiotics leads to drug resistance, posing a significant threat human health. Hydrogel-based wound dressings aimed at mitigating infections have emerged as an effective treatment. review presented herein particularly focuses on the hydrogels originating from natural polymers. To further enhance performance dressings, various strategies and approaches been developed endow with excellent broad-spectrum antibacterial activity. Those that are summarized in current intrinsic or stimuli-triggered bactericidal properties others serve vehicles for loading agents without antibiotics. Specific attention paid antimicrobial mechanisms hydrogels. Practical applications accelerate employing these antibiotic-free also introduced along discussion challenges perspectives leading new technologies.

Язык: Английский

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Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications

Advanced Science, Год журнала: 2023, Номер 10(30)

Опубликована: Авг. 26, 2023

Nitric oxide (NO) is a gaseous molecule that has central role in signaling pathways involved numerous physiological processes (e.g., vasodilation, neurotransmission, inflammation, apoptosis, and tumor growth). Due to its form, NO short half-life, physiology concentration dependent, often restricting function target site. Providing from an external source beneficial promoting cellular functions treatment of different pathological conditions. Hence, the multifaceted pathology garnered massive interest developing strategies deliver exogenous for various regenerative biomedical complexities. NO-releasing platforms or donors capable delivering controlled sustained manner tissues organs have advanced past few decades. This review article discusses detail generation via enzymatic synthase as well multiple biological modulates. The methods incorporating into diverse biomaterials including physical, chemical, supramolecular techniques are summarized. Then, these highlighted terms advancing medical problems.

Язык: Английский

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Chronic Inflammation in Non-Healing Skin Wounds and Promising Natural Bioactive Compounds Treatment

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(9), С. 4928 - 4928

Опубликована: Апрель 28, 2022

Chronic inflammation is one of the hallmarks chronic wounds and tightly coupled to immune regulation. The dysregulation system leads continuing impaired wound healing and, subsequently, skin wounds. In this review, we discuss role system, involvement inflammatory mediators reactive oxygen species, complication bacterial infections in healing, still-underexplored potential natural bioactive compounds treatment. We focus on with antioxidant, anti-inflammatory, antibacterial activities their mechanisms action, as well recent treatments therapeutic advancements capitalizing nanotechnology or new biomaterial platforms.

Язык: Английский

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Copper-Based Metal–Organic Framework as a Controllable Nitric Oxide-Releasing Vehicle for Enhanced Diabetic Wound Healing

ACS Applied Materials & Interfaces, Год журнала: 2020, Номер 12(16), С. 18319 - 18331

Опубликована: Март 27, 2020

Chronic wounds are one of the most serious complications diabetes mellitus. Even though utilizing nitric oxide (NO) as a gas medicine to repair diabetic presents promising strategy, controlling NO release behavior in affected area, which is vital for NO-based therapy, still remains significant challenge. In this work, copper-based metal–organic framework, namely, HKUST-1, has been introduced NO-loading vehicle, and sustained system with core–shell structure designed through electrospinning method. The results show that quantificationally stably loaded HKUST-1 particles, NO-loaded particles well incorporated into core layer coaxial nanofiber. Therefore, can be controllably released an average rate 1.74 nmol L–1 h–1 more than 14 days. Moreover, additional copper ions from degradable play synergistic role promote endothelial cell growth significantly improve angiogenesis, collagen deposition anti-inflammatory property wound bed, eventually accelerate healing. These suggest such framework material controllable NO-releasing vehicle highly efficient therapy wounds.

Язык: Английский

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Advances in gelatin-based hydrogels for wound management

Journal of Materials Chemistry B, Год журнала: 2020, Номер 9(6), С. 1503 - 1520

Опубликована: Дек. 22, 2020

The normal wound healing process and the foreign body reaction to management materials.

Язык: Английский

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Multiple Stimuli‐Responsive Nanozyme‐Based Cryogels with Controlled NO Release as Self‐Adaptive Wound Dressing for Infected Wound Healing

Advanced Functional Materials, Год журнала: 2023, Номер 33(31)

Опубликована: Апрель 23, 2023

Abstract Wound with drug‐resistant bacterial infections has become a serious challenge for the healthcare system, and designing wound dressing to self‐adapt need of different stage healing remains challenging. Herein, self‐adaptive dressings multiple stimuli‐responsiveness antibacterial activity are developed. Specifically, MoS 2 carrying reactive oxygen species (ROS) responsive nitric oxide (NO) release precursor L‐arginine (MSPA) is designed incorporated into carboxymethyl chitosan/ poly( N‐isopropylacrylamide) based cryogels (CMCS/PNIPAM) responsiveness (pH, near infrared (NIR), temperature) form that adapt therapeutic needs stages in infected healing. In response slightly acidic environment infection, assist capture capacity through acid‐triggered protonation behavior, effectively enhance photodynamic efficiency. Controllable on‐demand delivery ROS, NO, remote management biofluid achieved NIR light as trigger switch. The stimuli‐responsive nanozyme‐based efficiently eliminate MRSA biofilm NO assisted photodynamicand photothermal therapy (PDT&PTT). enzyme‐like activities relieved oxidative damage. Notably, these reduce alleviated stress, accelerate collagen deposition angiogenesis wounds, indicating provide new ideas treatment.

Язык: Английский

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