Functional Hydrogels as Wound Dressing to Enhance Wound Healing

ACS Nano, Год журнала: 2021, Номер 15(8), С. 12687 - 12722

Опубликована: Авг. 10, 2021

Hydrogels, due to their excellent biochemical and mechnical property, have shown attractive advantages in the field of wound dressings. However, a comprehensive review functional hydrogel as dressing is still lacking. This work first summarizes skin healing process relates evaluation parameters then reviews advanced functions dressings such antimicrobial adhesion hemostasis, anti-inflammatory anti-oxidation, substance delivery, self-healing, stimulus response, conductivity, recently emerged monitoring feature, strategies adopted achieve these are all classified discussed. Furthermore, applications for treatment different types wounds incisional excisional summarized. Chronic also mentioned, focus attention on infected wounds, burn diabetic Finally, future directions further proposed.

Язык: Английский

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pH/Glucose Dual Responsive Metformin Release Hydrogel Dressings with Adhesion and Self-Healing via Dual-Dynamic Bonding for Athletic Diabetic Foot Wound Healing

ACS Nano, Год журнала: 2022, Номер 16(2), С. 3194 - 3207

Опубликована: Янв. 31, 2022

In view of the lack a specific drug-sustained release system that is responsive to chronic wounds type II diabetic foot, and demands for frequent movement at foot wound, pH/glucose dual-responsive metformin-released adhesion-enhanced self-healing easy-removable antibacterial antioxidant conductive hemostasis multifunctional phenylboronic acid benzaldehyde bifunctional polyethylene glycol-co-poly(glycerol sebacic acid)/dihydrocaffeic l-arginine cografted chitosan (PEGS-PBA-BA/CS-DA-LAG, denoted as PC) hydrogel dressings were constructed based on double dynamic bond Schiff-base phenylboronate ester. It was further demonstrated PC promotes wound healing by reducing inflammation enhancing angiogenesis in rat model. addition, addition metformin (Met) graphene oxide (GO), well their synergy, confirmed better promote repair vivo. summary, PC/GO/Met hydrogels with stimuli-responsive ability easy removability have shown promoting effect athletic provide local-specific drug dual-response strategy treatment feet.

Язык: Английский

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Highly Stretchable, Adhesive, Biocompatible, and Antibacterial Hydrogel Dressings for Wound Healing

Advanced Science, Год журнала: 2021, Номер 8(8)

Опубликована: Март 5, 2021

Treatment of wounds in special areas is challenging due to inevitable movements and difficult fixation. Common cotton gauze suffers from incomplete joint surface coverage, confinement movement, lack antibacterial function, frequent replacements. Hydrogels have been considered as good candidates for wound dressing because their flexibility biocompatibility. Nevertheless, the adhesive, mechanical, properties conventional hydrogels are not satisfactory. Herein, cationic polyelectrolyte brushes grafted bacterial cellulose (BC) nanofibers introduced into polydopamine/polyacrylamide hydrogels. The 1D polymer rigid BC backbones enhance mechanical property hydrogels, realizing high tensile strength (21-51 kPa), large strain (899-1047%), ideal compressive property. Positively charged quaternary ammonium groups tethered provide long-lasting promote crawling proliferation negatively epidermis cells. Moreover, rich catechol capable adhering various surfaces, meeting adhesive demand movement areas. With above merits, demonstrate less inflammatory response faster healing speed vivo on rats. Therefore, multifunctional show stable covering, little displacement, antibacteria, fast healing, demonstrating promise dressing.

Язык: Английский

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Green Tea Derivative Driven Smart Hydrogels with Desired Functions for Chronic Diabetic Wound Treatment

Advanced Functional Materials, Год журнала: 2021, Номер 31(18)

Опубликована: Фев. 1, 2021

Abstract Current treatments for chronic diabetic wounds remain unsatisfactory due to the lack of ideal wound dressings that can integrate matching mechanical strength, fast self‐healability, facile dressing change, and multiple therapeutic effects into one system. In this work, benefiting from catechol groups effect epigallocatechin‐3‐gallate (EGCG, green tea derivative), a smart hydrogel be conveniently obtained through copolymerization complex formed by EGCG 3‐acrylamido phenylboronic acid (APBA) (the formation boronate ester bond) acrylamide. The resulting features adequate properties, self‐healing capability, tissue adhesiveness. Otherwise, substantial release not only realize anti‐oxidation, antibacterial, anti‐inflammatory proangiogenic effect, modulation macrophage polarization accelerate healing, but also facilitate easy change. This advanced provides effective way management may extended therapy other complicated healings.

Язык: Английский

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Promoting the healing of infected diabetic wound by an anti-bacterial and nano-enzyme-containing hydrogel with inflammation-suppressing, ROS-scavenging, oxygen and nitric oxide-generating properties

Biomaterials, Год журнала: 2022, Номер 286, С. 121597 - 121597

Опубликована: Май 22, 2022

Язык: Английский

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Bacterial Growth-Induced Tobramycin Smart Release Self-Healing Hydrogel for Pseudomonas aeruginosa-Infected Burn Wound Healing

ACS Nano, Год журнала: 2022, Номер 16(8), С. 13022 - 13036

Опубликована: Авг. 3, 2022

Burns are a common health problem worldwide and highly susceptible to bacterial infections that difficult handle with ordinary wound dressings. Therefore, burn repair is extremely challenging in clinical practice. Herein, series of self-healing hydrogels (QCS/OD/TOB/PPY@PDA) good electrical conductivity antioxidant activity were prepared on the basis quaternized chitosan (QCS), oxidized dextran (OD), tobramycin (TOB), polydopamine-coated polypyrrole nanowires (PPY@PDA NWs). These Schiff base cross-links between aminoglycoside antibiotic TOB OD enable be slowly released responsive pH. Interestingly, acidic substances during bacteria growth process can induce on-demand release TOB, avoiding abuse antibiotics. The antibacterial results showed QCS/OD/TOB/PPY@PDA9 hydrogel could kill high concentrations Pseudomonas aeruginosa (PA), Staphylococcus aureus, Escherichia coli short time bactericidal effect for up 11 days an agar plate diffusion experiment, while showing vivo activity. Excellent long-lasting properties make it suitable severely infected wounds. Furthermore, incorporation PPY@PDA endowed near-infrared (NIR) irradiation assisted drug-resistant bacteria, conductivity, Most importantly, PA-infected model, more effectively controlled inflammation levels promoted collagen deposition, vascular generation, earlier closure compared Tegaderm smart delivery advantageous bacterial-infected healing.

Язык: Английский

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Engineering Bioactive M2 Macrophage‐Polarized Anti‐Inflammatory, Antioxidant, and Antibacterial Scaffolds for Rapid Angiogenesis and Diabetic Wound Repair

Advanced Functional Materials, Год журнала: 2021, Номер 31(30)

Опубликована: Май 26, 2021

Abstract Diabetic wound healing still faces great challenges due to the excessive inflammation, easy infection, and impaired angiogenesis in beds. The immunoregulation of macrophages polarization toward M2 phenotype that facilitates transition from inflammation proliferation phase has been proved be an effective way improve diabetic healing. Herein, phenotype‐enabled anti‐inflammatory, antioxidant, antibacterial conductive hydrogel scaffolds (GDFE) for producing rapid repair are reported. GDFE fabricated facilely through dynamic crosslinking between polypeptide polydopamine graphene oxide. possess thermosensitivity, self‐healing behavior, injectability, broad‐spectrum activity, antioxidant anti‐inflammatory ability, electronic conductivity. effectively activates significantly promotes dermal fibroblasts, migration, vitro endothelial cells paracrine mechanisms. vivo results a full‐thickness model demonstrate can rapidly promote skin regeneration, fast anti‐inflammation macrophage polarization. This study provides highly efficient strategy treating designing polarization‐enabled bioactive materials.

Язык: Английский

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Natural Polymer-Based Antimicrobial Hydrogels without Synthetic Antibiotics as Wound Dressings

Biomacromolecules, Год журнала: 2020, Номер 21(8), С. 2983 - 3006

Опубликована: Июль 16, 2020

Wound healing is usually accompanied by bacterial infection. The excessive use of synthetic antibiotics leads to drug resistance, posing a significant threat human health. Hydrogel-based wound dressings aimed at mitigating infections have emerged as an effective treatment. review presented herein particularly focuses on the hydrogels originating from natural polymers. To further enhance performance dressings, various strategies and approaches been developed endow with excellent broad-spectrum antibacterial activity. Those that are summarized in current intrinsic or stimuli-triggered bactericidal properties others serve vehicles for loading agents without antibiotics. Specific attention paid antimicrobial mechanisms hydrogels. Practical applications accelerate employing these antibiotic-free also introduced along discussion challenges perspectives leading new technologies.

Язык: Английский

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Advances of hydrogel dressings in diabetic wounds

Biomaterials Science, Год журнала: 2020, Номер 9(5), С. 1530 - 1546

Опубликована: Дек. 22, 2020

Currently, the treatment and care of diabetic wounds, which generally possess characteristics a high amputation rate, recurrence rate mortality, has developed into worldwide challenge. Wound dressings have been playing an important role in wound continuously innovated to obtain many amazing properties. Among them, hydrogel become one most attractive promising because their considerable moisture retention, biocompatibility therapeutic In recent years, with depth understanding pathogenesis various functionalized reported shown encouraging results, brought great benefits improvement wounds. this work, we will systematically comprehensively summarize advances aiming provide not only theoretical support for dressing devising but also inspiration treatment.

Язык: Английский

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A spatiotemporal release platform based on pH/ROS stimuli-responsive hydrogel in wound repairing

Journal of Controlled Release, Год журнала: 2021, Номер 341, С. 147 - 165

Опубликована: Ноя. 20, 2021

Язык: Английский

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