Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 11, 2025
Helicoid
metal
nanoparticles
with
intrinsic
chirality
have
unveiled
tailorable
properties
and
unlocked
many
chirality-related
applications
across
various
fields.
Nevertheless,
the
existing
strategies
for
enantioselective
synthesis
of
helicoid
been
predominantly
limited
to
gold.
Here,
we
demonstrate
a
robust
versatile
strategy
beyond
gold,
leveraging
chiral
nanoconfinement
provided
by
SiO2
or
nanoshells.
The
enables
decoupling
ligand-directed
crystal
growth
from
induction,
allowing
independent
tuning
these
two
critical
aspects.
As
result,
this
approach
can
not
only
facilitate
replication
shapes
nanoshells
but
also
allow
generation
alternative
shapes.
By
employing
approach,
Pt,
Au@Pt,
Au@Pd,
Au@Ag,
Au@Cu
nanoparticles.
chiroplasmonic
Pt-
Pd-based
discovered,
inversion
Ag-based
via
facet
control
has
documented
theoretically
explained.
enriches
toolbox
creating
supports
their
exploration
in
diverse
applications.
Strategies
were
mainly
authors
present
helicoidal
gold
using
silica
shells.
Abstract
Chirality
is
a
universal
phenomenon
in
molecular
and
biological
systems,
denoting
an
asymmetric
configurational
property
where
object
cannot
be
superimposed
onto
its
mirror
image
by
any
kind
of
translation
or
rotation,
which
ubiquitous
on
the
scale
from
neutrinos
to
spiral
galaxies.
plays
very
important
role
life
system.
Many
molecules
body
show
chirality,
such
as
“codebook”
earth's
diversity‐DNA,
nucleic
acid,
etc.
Intriguingly,
living
organisms
hierarchically
consist
homochiral
building
blocks,
for
example,
l
‐amino
acids
d
‐sugars
with
unknown
reason.
When
chirality
interact
these
chiral
factors,
only
one
conformation
favors
positive
development
life,
that
is,
host
environment
can
selectively
conformations.
The
differences
interactions
are
often
manifested
recognition,
mutual
matching,
molecules,
means
stereoselectivity
produce
changes
pharmacodynamics
pathology.
Here,
latest
investigations
summarized
including
construction
applications
materials
based
natural
small
source,
biomacromolecules
sources,
material
synthesized
design
source.
Advanced Materials,
Год журнала:
2024,
Номер
36(18)
Опубликована: Янв. 19, 2024
Abstract
Machine
learning
holds
significant
research
potential
in
the
field
of
nanotechnology,
enabling
nanomaterial
structure
and
property
predictions,
facilitating
materials
design
discovery,
reducing
need
for
time‐consuming
labor‐intensive
experiments
simulations.
In
contrast
to
their
achiral
counterparts,
application
machine
chiral
nanomaterials
is
still
its
infancy,
with
a
limited
number
publications
date.
This
despite
great
advance
development
new
sustainable
high
values
optical
activity,
circularly
polarized
luminescence,
enantioselectivity,
as
well
analysis
structural
chirality
by
electron
microscopy.
this
review,
an
methods
used
studying
provided,
subsequently
offering
guidance
on
adapting
extending
work
nanomaterials.
An
overview
within
framework
synthesis–structure–property–application
relationships
presented
insights
how
leverage
study
these
highly
complex
are
provided.
Some
key
recent
reviewed
discussed
Finally,
review
captures
achievements,
ongoing
challenges,
prospective
outlook
very
important
field.
The
differentiation
of
neural
stem
cells
via
nanomaterials
has
attracted
attention
and
become
a
potential
tool.
However,
the
chirality
effect
in
cell
not
been
investigated.
Here,
this
study
shows
that
chiral
nanoparticles
(NPs)
with
strong
can
efficiently
accelerate
mouse
(NSCs)
into
neurons
under
near-infrared
(NIR)
light
illumination.
L-type
NPs
are
1.95
times
greater
than
D-type
promoting
NSCs
due
to
their
1.47-fold
endocytosis
efficiency.
Whole
gene
expression
map
analysis
reveals
circularly
polarized
illumination
irradiation
significantly
upregulate
Map2,
Yap1,
Taz
genes,
resulting
mechanical
force,
cytoskeleton
protein
action,
accelerated
differentiation.
In
vivo
experiments
show
successful
further
alleviate
symptoms
Alzheimer's
disease
mice.
Moreover,
clearance
on
amyloid
hyperphosphorylated
p-tau
reachs
68.24%
66.43%,
respectively,
synergy
NIR
irradiation.
findings
suggest
may
have
advantages
guiding
development
be
used
biomedicine.
ACS Nano,
Год журнала:
2023,
Номер
17(11), С. 9850 - 9869
Опубликована: Июнь 2, 2023
The
nanoscale
properties
of
nanomaterials,
especially
nanoparticles,
including
size,
shape,
and
surface
charge,
have
been
extensively
studied
for
their
impact
on
nanomedicine.
Given
the
inherent
chiral
nature
biological
systems
high
enantiomeric
selectivity,
there
is
rising
interest
to
manipulate
chirality
nanomaterials
enhance
biomolecular
interactions
improve
nanotherapeutics.
Chiral
nanostructures
are
currently
more
prevalently
used
in
biosensing
diagnostic
applications
owing
distinctive
physical
optical
properties,
but
they
hold
great
promise
use
In
this
Review,
we
first
discuss
stereospecific
between
biomolecules
before
comparing
synthesis
characterization
methods
nanoparticles
nanoassemblies.
Finally,
examine
nanotherapeutics
cancer,
immunomodulation,
neurodegenerative
diseases
propose
plausible
mechanisms
which
interact
with
cells
manipulation.
This
Review
a
timely
reminder
arsenal
modifications
boost
research
Stem Cell Research & Therapy,
Год журнала:
2024,
Номер
15(1)
Опубликована: Май 7, 2024
Abstract
Background
Alzheimer’s
disease
(AD)
is
a
prevalent
form
of
dementia
leading
to
memory
loss,
reduced
cognitive
and
linguistic
abilities,
decreased
self-care.
Current
AD
treatments
aim
relieve
symptoms
slow
progression,
but
cure
elusive
due
limited
understanding
the
underlying
mechanisms.
Main
content
Stem
cell
technology
has
potential
revolutionize
research.
With
ability
self-renew
differentiate
into
various
types,
stem
cells
are
valuable
tools
for
modeling,
drug
screening,
therapy.
Recent
advances
have
broadened
our
beyond
deposition
amyloidβ
(Aβ)
or
tau
proteins
in
encompass
risk
genes,
immune
system
disorders,
neuron–glia
mis-communication,
relying
heavily
on
cell-derived
models.
These
cell-based
models
(e.g.,
organoids
microfluidic
chips)
simulate
vivo
pathological
processes
with
extraordinary
spatial
temporal
resolution.
technologies
alleviate
pathology
through
pathways,
including
immunomodulation,
replacement
damaged
neurons,
neurotrophic
support.
In
recent
years,
transplantation
glial
like
oligodendrocytes
infusion
exosomes
become
hot
research
topics.
Conclusion
Although
therapies
face
several
challenges,
such
as
extended
culture
time
low
differentiation
efficiency,
they
still
show
considerable
treatment
likely
preferred
