Communications Chemistry,
Год журнала:
2024,
Номер
7(1)
Опубликована: Дек. 18, 2024
Synthetic
chemistry
approaches
for
direct
C–H
bond
alkylation
offers
a
promising
alternative
to
traditional
functional-group-centered
strategies
which
often
involve
multi-step
procedures
and
may
suffer
from
variety
of
challenges
including
scalability.
Here,
we
introduce
resonant
mixing
as
an
efficient
method
meta-C–H
arenes
using
Ru-catalyst,
avoiding
the
need
bulk
solvents,
external
temperature,
or
light.
The
described
methodology
is
highly
rapid,
enabling
multigram-scale
synthesis
meta-alkylation
products
within
short
reaction
time
achieving
very
high
turnover
frequency.
operates
via
radical
mechanism
characterized
by
its
mild
conditions,
substrate
compatibility,
exceptional
meta-selectivity,
all
while
significantly
reducing
times.
authors
acoustic
Ru-catalyst
mechanism,
An
efficient
approach
for
the
remote
C-H
alkylation
of
arenes,
employing
a
variety
N-directing
groups
is
described.
This
method
facilitates
straightforward
synthesis
valuable
phenylethylamine
derivatives
by
exclusively
cleaving
benzylic
C-N
bond
in
aziridines.
Furthermore,
these
products
can
easily
remove
protecting
groups,
resulting
meta-substituted
compounds,
such
as
amines
and
ketones,
which
hold
significance
synthetic
chemistry.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(47)
Опубликована: Окт. 10, 2023
Metal-catalyzed
C-H
activation
strategies
provide
an
efficient
approach
for
synthesis
by
minimizing
atom,
step,
and
redox
economy.
Developing
milder,
greener,
more
effective
protocols
these
is
always
highly
desirable
to
the
scientific
community.
In
this
study,
utilization
of
a
single
rhodium
complex
enabled
visible-light-induced
late-stage
biaryl-type
phosphines
with
alkynyl
bromides,
employing
inherent
phosphorus
atoms
as
directing
groups.
This
chemistry
combines
P(III)-directed
visible
light
photocatalysis,
under
exogenous
photosensitizer-free
conditions,
offering
unique
platform
ligand
design
preparation.
Furthermore,
study
also
explores
asymmetric
catalysis
coordination
resulting
P-alkyne
hybrid
ligands
specific
transition
metals.
Experimental
results
density
functional
theory
calculations
demonstrate
mechanistic
intricacies
transformation.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(25)
Опубликована: Апрель 18, 2024
Transition
metal-catalyzed
C-H
arylation
polymerization
(CHAP)
is
an
attractive
tool
for
constructing
π-conjugated
polymers
in
a
sustainable
manner.
However,
the
existing
methods
primarily
rely
on
palladium
catalysis,
which
usually
entails
harsh
reaction
conditions
and
branching/cross-linking.
Here
we
report
first
example
of
ambient-temperature
ruthenium-catalyzed
induced
by
visible
light
irradiation.
The
present
can
produce
various
meta-
para-linked
excellent
yields
with
high
molecular
weights.
remarkable
feature
our
mild
platform
represented
chemoselectivity,
leading
to
that
are
otherwise
inaccessible
under
conventional
at
temperatures.
Organic Letters,
Год журнала:
2024,
Номер
26(15), С. 2913 - 2917
Опубликована: Апрель 3, 2024
C–C
σ-bond
cleavage
and
reconstruction
is
a
significant
tool
for
structural
modification
in
synthetic
chemistry
but
it
remains
formidable
challenge
to
perform
on
unstrained
skeletons.
Herein,
we
describe
radical
addition-enabled
cleavage/reconstruction
reaction
of
allyl
ketones
access
various
functional
indanones
bearing
benzylic
quaternary
center.
The
utility
this
method
has
been
showcased
by
the
first
total
synthesis
carexane
L,
an
indanone-based
natural
product.
A
novel
Ru-catalyzed
radical-triggered
trifunctionalization
of
hexenenitriles
is
presented,
employing
a
strategy
remote
cyano
group
migration
and
meta-C(sp2)-H
functionalization.
Through
migration,
the
alkenyl
moiety
undergoes
difunctionalization
to
formation
benzylic
radical
intermediate.
This
intermediate
facilitates
para-selective
C-H
bond
addition
relative
C-Ru
within
Ru(III)
complex,
ultimately
enabling
trifunctionalization.
methodology
provides
an
efficient
route
diverse
array
nitrile-containing
compounds
with
broad
functional
compatibility.
Herein
we
present
photoinduced
cobaloxime-catalyzed
selective
remote
desaturation
of
aliphatic
alcohols.
This
transformation,
which
proceeds
efficiently
at
room
temperature,
facilitates
the
synthesis
valuable
cyclic
and
acyclic
allylic
homoallylic
alcohols
from
readily
available
saturated
Remarkably,
this
method
obviates
need
for
external
oxidants,
noble
metal
catalysts,
phosphine
ligands.
Chemistry - A European Journal,
Год журнала:
2023,
Номер
29(44)
Опубликована: Май 23, 2023
A
ruthenium-catalyzed
para-selective
alkylation
of
protected
anilines
to
construct
α-arylacetonitrile
skeletons
has
been
reported.
We
firstly
disclosed
the
ethyl
2-bromo-2-cyanopropanoate
was
an
effective
alkylating
reagent
in
ruthenmuim-catalyzed
remote-selective
C-H
functionalization.
wide
variety
can
be
directly
obtained
with
moderate
good
yields.
Importantly,
products
contain
both
nitrile
and
ester
groups
guaranteeing
its
direct
transformation
into
other
useful
synthetic
units,
indicating
importance
this
method.
