Zr-Catalyzed Assembly of 1,1,1-Triborylalkanes from Alkenes and HBpin DOI
Kang Liu, Liang Meng, Qiuling Song

и другие.

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Май 10, 2025

Multiboronated compounds play more and significant roles in the chemical community, 1,1,1-triborylalkanes have emerged as versatile building blocks organic synthesis. However, efficient strategies for assembly of such are very rare. A general atom-economical synthesis from various alkenes with pinacolborane (HBpin) is reported first time. The success this transformation relies on use commercially available Schwartz reagent (Cp2ZrHCl) a catalyst, enabling sequential dehydrogenative borylation hydroboration. This reaction demonstrates excellent selectivity, high yields, broad functional group tolerance. Mechanistic investigations reveal that process begins two consecutive borylations catalyzed by zirconium, producing 1,1-diborylalkene intermediate, which subsequently undergoes hydroboration HBpin to afford 1,1,1-triborylalkanes. Notably, approach allows remote 1,1,1-triboration internal alkenes.

Язык: Английский

Green procedures for synthesizing potential hNMDA receptor allosteric modulators through reduction and one-pot reductive acetylation of nitro(hetero)arenes using a superparamagnetic Fe3O4@APTMS@Cp2ZrClx (x = 0, 1, 2) nanocatalyst DOI Creative Commons
Hossein Mousavi, Behzad Zeynizadeh,

Farhad Sepehraddin

и другие.

Nanoscale Advances, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

In this research, we have developed diverse strategies for synthesizing potential h NMDA receptor allosteric modulators through reduction and one-pot reductive acetylation of nitro(hetero)arenes using a mesoporous zirconocene-containing nanocatalyst.

Язык: Английский

Процитировано

0
Zr-Catalyzed Assembly of 1,1,1-Triborylalkanes from Alkenes and HBpin DOI
Kang Liu, Liang Meng, Qiuling Song

и другие.

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Май 10, 2025

Multiboronated compounds play more and significant roles in the chemical community, 1,1,1-triborylalkanes have emerged as versatile building blocks organic synthesis. However, efficient strategies for assembly of such are very rare. A general atom-economical synthesis from various alkenes with pinacolborane (HBpin) is reported first time. The success this transformation relies on use commercially available Schwartz reagent (Cp2ZrHCl) a catalyst, enabling sequential dehydrogenative borylation hydroboration. This reaction demonstrates excellent selectivity, high yields, broad functional group tolerance. Mechanistic investigations reveal that process begins two consecutive borylations catalyzed by zirconium, producing 1,1-diborylalkene intermediate, which subsequently undergoes hydroboration HBpin to afford 1,1,1-triborylalkanes. Notably, approach allows remote 1,1,1-triboration internal alkenes.

Язык: Английский

Процитировано

0