Finely Tuned γ Tracks Medication Cycles in Parkinson's Disease: An Ambulatory Brain‐Sense Study

Movement Disorders, Год журнала: 2025, Номер unknown

Опубликована: Март 13, 2025

Abstract Background Novel commercial brain‐sense neurostimulators enable us to contextualize brain activity with symptom and medication states in real‐life ambulatory settings Parkinson's disease (PD). Although various candidate biomarkers have been proposed for adaptive deep stimulation (DBS), a comprehensive comparison of their profiles is lacking. Objectives To systematically compare the neurophysiological dynamics clinical properties three biomarkers—low‐frequency, beta (β), finely tuned γ (FTG) activity. Methods We investigated 14 PD patients implanted Medtronic Percept PC, who underwent up two 4‐week multimodal recording periods on regular stimulation. Subthalamic nucleus local field potentials (LFPs) low‐frequency, β, FTG were recorded. Additionally, objective motor states, physical heart rate using wearables, as well medication‐intake times, sleep‐awake subjective diaries co‐registered. LFP also compared high‐resolution in‐hospital recordings under off / dopaminergic conditions. Results reliably indexed setting at group individual levels, these spectral could be anticipated by recordings. Both low‐frequency correlated wearable‐based dyskinesia scores, whereas diary‐based events only linked FTG. Importantly, indicated ‐medication regardless presence despite potential motion artifacts. The 24‐hour profile revealed large circadian power shifts that may overdrive dynamics. Conclusion Despite limitations low‐temporal resolution recordings, this work provides valuable insights into biomarkers. Specifically, it highlights utility primary reliable indicator DBS. © 2025 Author(s). Movement Disorders published Wiley Periodicals LLC behalf International Parkinson Disorder Society.

Язык: Английский

---

Construction and validation of a predictive model for sleep disorders among pregnant women

BMC Pregnancy and Childbirth, Год журнала: 2025, Номер 25(1)

Опубликована: Март 6, 2025

Sleep disorders are among the most common major problems during pregnancy. Most studies on sleep of pregnant women closely related to adverse birth outcomes. In this study, our aim was develop and validate a predictive model for risk in women. A total 2,467 healthy were enrolled randomly partitioned into training set validation at ratio 7:3. During variable selection stage, Pearson's chi-square test employed identify variables with p-value below 0.05, which then designated as candidate subsequent logistic regression analysis. Concurrently, LASSO technique utilized sift through isolate valuable variables. Ultimately, we developed binary Logistic models predicated (Model 1) 2). The performance nomograms evaluated using Bootstrap resampling procedure, sensitivity specificity receiver-operating characteristic (ROC), area under ROC curve (AUC), decision analysis (DCA). 439 (25.4%) 208 (28.1%) exhibited disorder, respectively. prediction shared 6 factors (age, anxiety, depression, family functions, degree pregnancy reaction, pre-pregnancy physical condition). Model 1, 69.4%, 59.6%. When weeks, residence, only child included 2, 82.4% 54.8%. set, areas 1 2 0.678 (0.635, 0.720), 0.719 (0.678, 0.761), showed that calibration is approximately distributed along reference line. Decision analyses demonstrated favorable net benefit within range threshold probability nomograms. superior performance, can serve convenient reliable tool predicting

Язык: Английский

---

Local Field Potential Biomarkers of Non‐Motor Symptoms in Parkinson's Disease: Insights From the Subthalamic Nucleus in Deep Brain Stimulation

European Journal of Neuroscience, Год журнала: 2025, Номер 61(5)

Опубликована: Март 1, 2025

Non-motor symptoms can severely affect the quality of life Parkinson's disease-afflicted patients, with most common ones being pain, sleep impairments, and neuropsychiatric manifestations. In advanced cases, complex fluctuations motor non-motor occur despite optimal medication. Research on deep brain stimulation subthalamic nucleus suggests that it may provide benefits for treating in addition to improving symptoms. With recent advancements technology, simultaneous recording local field potentials delivery therapeutic is possible. This opens new possibilities better understanding pathophysiology disease identifying potential electrophysiological biomarkers accurately represent these Specifically, this review aims highlight nucleus. The main findings indicate activities beta frequency band are associated nociception impairments such as insomnia rapid eye movement behavior disorders. Additionally, theta alpha bands seem reflect neurocognitive manifestations, including depression impulse control A could improve clinical management disease. They hold promise adjusting parameters open-loop settings might eventually be applied closed-loop systems, though their true impact remains uncertain.

Язык: Английский

---

The Past and Future of Sleep Medicine

Sleep Medicine Clinics, Год журнала: 2024, Номер 20(1), С. 1 - 17

Опубликована: Дек. 9, 2024

Язык: Английский

---