Phthalates toxicity in vivo to rats, mice, birds, and fish: A thematic scoping review DOI Creative Commons
Mohammad Shah Alam,

Zannatul Maowa,

Mohammad Nazmol Hasan

и другие.

Heliyon, Год журнала: 2024, Номер 11(1), С. e41277 - e41277

Опубликована: Дек. 18, 2024

Язык: Английский

Impact of microplastics exposure on liver health: A comprehensive meta-analysis DOI
Yujian Zhang, J. Yuan, Ting Mao

и другие.

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Год журнала: 2024, Номер 288, С. 110080 - 110080

Опубликована: Ноя. 22, 2024

Язык: Английский

Процитировано

1
Microplastics Exposure Aggravates Synovitis and Pyroptosis in SLE by Activating NF-κB and NRF2/KEAP1 Signaling DOI Creative Commons

Wenxiang Zeng,

Shan He, Ying Zhao

и другие.

Toxics, Год журнала: 2024, Номер 12(12), С. 840 - 840

Опубликована: Ноя. 22, 2024

Microplastics (MPs) represent an emerging pollutant capable of entering the human body through respiratory and digestive systems, thereby posing significant health risks. Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects multiple organ often presenting with polyarticular joint manifestations. Despite its relevance, there currently limited research on impact MPs arthritis. This study aims to investigate effects inflammation in SLE. MRL/lpr mice exhibit SLE similar humans. We administered either 0.5 mg/kg or 5 8-week-old female via oral ingestion. Our findings indicate exposure can lead synovial damage, adversely affecting morphology function knee joint, along increased oxidative stress, apoptosis, fibrosis, secretion inflammatory cytokines. Notably, significantly enhanced cell pyroptosis by upregulating expression NLRP3, CASPASE-1, GSDMD, IL-1β, IL-18. Mechanistic analyses further demonstrated activates NF-κB NRF2/KEAP1 signaling pathways. Overall, our vivo suggest promotes stress signaling, disrupting structure tissue. provides new insights into damage associated exposure.

Язык: Английский

Процитировано

1
Environmental microplastic and phthalate esters co-contamination, interrelationships, co-toxicity and mechanisms. A review DOI
Huan Liu, Dongdong Zheng, Xixia Liu

и другие.

Environmental Geochemistry and Health, Год журнала: 2024, Номер 46(12)

Опубликована: Ноя. 21, 2024

Язык: Английский

Процитировано

1
Behenic acid protects the testosterone cycle and prevents the sperm apoptosis and protein loss in phthalate exposure by inhibiting oxidative stress and stimulating ATPase activity DOI Creative Commons
Khaled M. M. Koriem, Mohamed Elmasry

Toxicology Reports, Год журнала: 2024, Номер 13, С. 101845 - 101845

Опубликована: Ноя. 29, 2024

Язык: Английский

Процитировано

1
Microplastic Exposure Aggravates Synovitis and Pyroptosis in Sle by Activating Nf-Κb and Nrf2/Keap1 Signaling DOI

Zeng Wenxiang,

Ying Zhao,

Mingjian Jiang

и другие.

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0
Associations between Urinary Phthalate Metabolites with BDNF and Behavioral Function among European Children from Five HBM4EU Aligned Studies DOI Creative Commons
Elena Salamanca‐Fernández, Lydia Espín-Moreno, Alicia Olivas-Martínez

и другие.

Toxics, Год журнала: 2024, Номер 12(9), С. 642 - 642

Опубликована: Авг. 31, 2024

Based on toxicological evidence, children’s exposure to phthalates may contribute altered neurodevelopment and abnormal regulation of brain-derived neurotrophic factor (BDNF). We analyzed data from five aligned studies the Human Biomonitoring for Europe (HBM4EU) project. Ten phthalate metabolites protein BDNF levels were measured in urine samples 1148 children aged 6–12 years Italy (NACII-IT cohort), Slovakia (PCB-SK Hungary (InAirQ-HU cohort) Norway (NEBII-NO). Serum was also available 124 Slovenian (CRP-SLO cohort). Children’s total, externalizing internalizing behavioral problems assessed using Child Behavior Checklist at 7 age (only NACII-IT Adjusted linear negative binomial regression models fitted, together with weighted quantile sum (WQS) assess mixture associations. Results showed that, boys but not girls cohort, each natural-log-unit increase mono-n-butyl (MnBP) Mono(2-ethyl-5-oxohexyl) (MEOHP) cross-sectionally associated higher [incidence rate ratio (IRR): 1.20; 95% CI: 1.02, 1.42 1.26; 1.03, 1.55, respectively]. A suggestive association observed per tertile whole population (WQS—IRR = 1.15; 0.97, 1.36) (IRR 0.96, 1.49). In NACII-IT, PCB-SK, InAirQ-HU NEBII-NO cohorts together, urinary strongly levels, WQS confirming a (percent change (PC) 25.9%; 17.6, 34.7), (PC 18.6%; 7.92, 30.5) mainly among 36.0%; 24.3, 48.9). Among CRP-SLO boys, ∑DINCH concentration lower serum (PC: −8.8%; −16.7, −0.3). predicted worse scores all (IRR: 1.00, 1.32). suggest that (1) di-n-butyl (DnBP) di(2-ethylhexyl) (DEHP) is more (2) DINCH associate systemic (3) concentrations (although caution needed since possibility “urine bias” could explain these associations noncausal terms identified) (4) predict problems. Given this first study examine relationship between metabolite biomarkers, future are validate

Язык: Английский

Процитировано

0
Metabolic and neurodevelopmental effects of the environmental endocrine disruptor di-2-ethylhexyl phthalate: a review DOI
Weiwei Wang, Xiaolei Liu,

Yu Ding

и другие.

Environmental Chemistry Letters, Год журнала: 2024, Номер unknown

Опубликована: Сен. 20, 2024

Язык: Английский

Процитировано

0
Effects of Microplastics on Chemo-Resistance and Tumorigenesis of Colorectal Cancer DOI
Wen Pan, Mingqing Zhang, Jie Hao

и другие.

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0
Phthalates toxicity in vivo to rats, mice, birds, and fish: A thematic scoping review DOI Creative Commons
Mohammad Shah Alam,

Zannatul Maowa,

Mohammad Nazmol Hasan

и другие.

Heliyon, Год журнала: 2024, Номер 11(1), С. e41277 - e41277

Опубликована: Дек. 18, 2024

Язык: Английский

Процитировано

0