Journal of Pain Research,
Год журнала:
2025,
Номер
Volume 18, С. 1313 - 1323
Опубликована: Март 1, 2025
Poor
pain
control
may
lead
to
persistent
physical
discomfort
and
even
reduced
perceptual
abilities.
This
research
seeks
investigate
the
relationship
between
status
duration
sensory
impairments.
study
used
data
on
impairments
from
National
Health
Nutrition
Examination
Survey
(NHANES)
conducted
2011
2014,
including
8043
participants.
Functional
of
vision,
hearing,
smell,
taste
was
gathered
using
structured
questionnaires.
Logistic
regression
models
were
evaluate
association
status,
duration,
total
number
specific
deficits,
while
adjusting
for
key
covariates
such
as
age,
gender,
BMI,
socioeconomic
status.
Stratified
analysis
performed
determine
factors
that
might
confound
this
relationship.
The
multivariable-adjusted
model
showed
individuals
with
1
3
years
had
a
64%
increased
risk
impairment
compared
those
without
(OR
1.640,
95%
CI
1.132-2.376,
P
=
0.016),
over
90.9%
1.909,
1.472-2.475,
0.001).
We
also
found
statistically
significant
≥
year
visual
1.841,
1.252-2.705,
<
0.01).
Furthermore,
participants
>
significantly
associated
olfactory
2.264,
1.538-3.331,
0.001)
2.070,
1.335-3.209,
However,
no
observed
hearing
in
any
category.
results
suggest
longer
chronic
are
at
higher
impairments,
particularly
visual,
olfactory,
Timely
effective
management
help
reduce
long-term
CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(10)
Опубликована: Окт. 1, 2024
Huntington's
disease
(HD)
is
a
devastating
neurodegenerative
that
manifested
by
gradual
loss
of
physical,
cognitive,
and
mental
abilities.
As
the
advances,
age
has
major
impact
on
pathogenic
signature
mutant
huntingtin
(mHTT)
protein
aggregation.
This
review
aims
to
explore
intricate
relationship
between
aging,
mHTT
toxicity,
cellular
senescence
in
HD.
Scientific
data
interplay
mHTT,
HD
were
collected
from
several
academic
databases,
including
PubMed,
Google
Scholar,
Google,
ScienceDirect.
The
search
terms
employed
"AGING,"
"HUNTINGTON'S
DISEASE,"
"MUTANT
HUNTINGTIN,"
"CELLULAR
SENESCENCE."
Additionally,
gather
information
molecular
mechanisms
potential
therapeutic
targets,
was
extended
include
relevant
such
as
"DNA
DAMAGE,"
"OXIDATIVE
STRESS,"
"AUTOPHAGY."
According
research,
aging
leads
worsening
pathophysiology
through
some
processes.
result
accumulation,
promoted,
which
causes
DNA
damage,
oxidative
stress,
decreased
autophagy,
increased
inflammatory
responses.
Pro-inflammatory
cytokines
other
substances
are
released
senescent
cells,
may
worsen
neuronal
damage
course
disease.
It
been
shown
treatments
directed
at
these
pathways
reduce
symptoms
enhance
longevity
experimental
animals,
pointing
new
possibility
treating
condition.
Through
their
amplification
harmful
effects
play
crucial
roles
development
Comprehending
interplays
creates
novel
opportunities
for
measures
targeted
alleviating
enhancing
patients'
quality
life.
European journal of psychotraumatology,
Год журнала:
2025,
Номер
16(1)
Опубликована: Фев. 13, 2025
Background:
Depression
is
a
prevalent
mental
disorder
with
high
morbidity
and
mortality
globally.
Methylmalonic
acid
(MMA)
involved
in
the
pathogenesis
of
numerous
diseases.
However,
it
unclear
whether
there
an
association
between
MMA
prevalence
depression.
Journal of Integrative Neuroscience,
Год журнала:
2023,
Номер
22(4)
Опубликована: Июль 17, 2023
Background:
Stress
can
lead
to
emotional
and
mental
symptoms
such
as
anxiety,
sadness,
panic
attacks,
depression.
Malic
acid
was
chosen
due
malic
has
the
ability
improve
antioxidant
activity
improves
liver
damage.
This
study
evaluates
anti-depressant
in
hypothalamus
of
stressed
rats.
Methods:
Thirty-six
male
albino
rats
were
divided
into
2
equal
groups;
Normal
chronic
mild
stress
(CMS)
3
control,
acid,
venlafaxine
drug
groups:
normal
administered
orally
with
1
mL
saline
solution,
250
mg/kg
20
drug,
respectively.
CMS
CMS,
+
drug:
All
above-mentioned
treatments
once
a
day
by
oral
gavage
for
6
weeks.
Results:
The
obtained
results
revealed
that
animal
behavioral
tests
forced
swimming
test,
tail
suspension
sucrose
preference
open-field
test
(center
square
entries
center
duration
distance
travelled
test),
norepinephrine,
dopamine,
serotonin,
γ-aminobutyric
nicotinamide-adenine
dinucleotide
phosphate
(NADPH)
oxidase
activity,
oxidative
index,
conjugated
dienes,
catalase,
glutathione
peroxidase,
superoxide
dismutase,
malondialdehyde,
interleukin-6,
tumor
necrosis
factor-α,
interleukin-10,
interleukin-1β,
sodium/potassium-ATPase
histamine-N-methyl
transferase
(Hnmt)
tyrosine
hydroxylase
(TH)
enzymes
rats,
returned
approaching
state
group
after
treating
Conclusions:
ameliorated
stressed-related
it
inhibited
anion
neuro-inflammation
Reviews in Medical Virology,
Год журнала:
2023,
Номер
34(1)
Опубликована: Ноя. 20, 2023
The
immunopathology
of
herpes
simplex
virus
(HSV)-associated
neuroinflammation
is
a
captivating
and
intricate
field
study
within
the
scientific
community.
HSV,
renowned
for
its
latent
infection
capability,
gives
rise
to
spectrum
neurological
expressions,
ranging
from
mild
symptoms
severe
encephalitis.
enigmatic
interplay
between
host's
immune
responses
profoundly
shapes
outcome
these
infections.
This
review
delves
into
multifaceted
reactions
triggered
by
HSV
neural
tissues,
intricately
encompassing
innate
adaptive
immunity.
Furthermore,
this
analysis
delicate
equilibrium
defence
potential
immunopathology-induced
damage.
It
meticulously
dissects
roles
diverse
cells,
cytokines,
chemokines,
unravelling
intricacies
modulation
subsequent
effects.
By
exploring
HSV's
manipulation
exploitation
mechanisms,
endeavours
unveil
enigmas
surrounding
HSV-associated
neuroinflammation.
comprehensive
understanding
enhances
our
grasp
viral
pathogenesis
holds
promise
pioneering
therapeutic
strategies
designed
mitigate
ramifications
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
166, С. 115313 - 115313
Опубликована: Авг. 10, 2023
Treatment-resistant
depression
(TRD)
is
a
challenging
issue
to
address.
Repetitive
transcranial
magnetic
stimulation
(rTMS)
commonly
used
but
shows
varying
efficacy,
necessitating
deeper
understanding
of
physiology
and
rTMS
mechanisms.
Notably,
an
increasing
amount
recent
data
has
displayed
the
connection
TRD
its
clinical
outcome
with
chronic
inflammatory
processes.
The
current
study
included
19
patients
undergoing
11
depressed
responding
medication
as
comparison
group.
We
assessed
therapeutic
efficacy
using
MADRS,
HAM-D-17,
GAD-7,
PHQ-9
tests.
Inflammatory
markers,
neurotrophins,
associated
miRNAs
were
measured
in
blood
serum
before
during
treatment.
A
control
group
18
healthy
individuals
provided
baseline
data.
results
our
showed
significantly
higher
levels
pro-inflammatory
interleukins-6
-
8
compared
drug-responders,
which
also
related
more
severe
symptoms
In
addition,
patients,
both
treatment,
exhibited
average
concentrations
interleukin-18
lower
anti-neuroinflammatory
miR-146a-5p
controls.
observed
that
expression
miR-16-5p,
miR-93-5p,
especially
correlated
changes
following
rTMS.
Our
confirmed
possess
status,
while
was
demonstrated
have
considerable
potential
for
predicting
their
treatment
success.
