Sanqi oral solution alleviates podocyte apoptosis in experimental membranous nephropathy by mediating EMT through the ERK/CK2-α/β-catenin pathway
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Май 9, 2025
Introduction
Sanqi
oral
solution
(SQ)
is
a
Chinese
medicine
that
has
been
used
well
to
treat
idiopathic
membranous
nephropathy
(IMN).
It
demonstrated
mitigate
IMN
proteinuria
by
inhibiting
podocyte
apoptosis.
however,
the
precise
mechanism
not
fully
elucidated.
Methods
A
passive
Heymann
(PHN)
rat
model
was
mimic
in
vivo
disease
characteristics
of
IMN.
The
PHN
rats
were
intragastrically
administered
SQ
(12.6/6.3
mL/kg)
or
tacrolimus
(0.315
mg/kg)
for
21
days.
applied
ADR-induced
podocytes
vitro
.
effects
on
and
its
underlying
mechanisms
determined
measuring
biochemical
indices,
pathomorphological
characteristics,
membrane
attack
complex
(MAC),
cell
morphology,
protein
levels.
Results
ingredients
found
serum
underscored
their
successful
absorption
rats.
In
rats,
induced
significant
reduction
proteinuria,
MAC,
C5b-9,
glomerular
basement
thickness,
along
with
drop
apoptotic
podocytes.
Similarly,
exerted
protective
effect
against
injury
Furthermore,
inhibition
ERK/CK2-α/β-catenin
pathway-mediated
epithelial-to-mesenchymal
transition
(EMT)
be
involved
anti-apoptotic
podocytes,
marked
vimentin
α-SMA
induction
Synaptopodin
Podocin
Conclusion
Inhibition
EMT
via
pathway
may
main
which
suppresses
apoptosis
Язык: Английский
Interrelation of Natural Polyphenol and Fibrosis in Diabetic Nephropathy
Molecules,
Год журнала:
2024,
Номер
30(1), С. 20 - 20
Опубликована: Дек. 25, 2024
Diabetic
nephropathy
(DN)
is
a
common
and
serious
complication
of
diabetes
mellitus
major
cause
end-stage
renal
disease
(ESRD).
Renal
fibrosis,
which
corresponds
to
excessive
deposition
extracellular
matrix
leads
scarring,
characteristic
feature
the
various
progressive
stages
DN.
It
can
trigger
pathological
processes
leading
activation
autophagy,
inflammatory
responses
vicious
circle
oxidative
stress
inflammation.
Although
it
known
that
DN
be
alleviated
by
mechanisms
linked
antioxidants,
reducing
inflammation
improving
how
improve
fibrosis
using
natural
polyphenols
needs
studied
further.
Nowadays,
polyphenolic
compounds
with
excellent
safety
efficacy
are
playing
an
increasingly
important
role
in
drug
discovery.
Therefore,
this
review
reveals
multiple
associated
DN,
as
well
different
signaling
pathways
(including
TGF-β/SMAD,
mTORC1/p70S6K,
JAK/STAT/SOCS
Wnt/β-catenin)
potential
fibrotic
niche.
In
parallel,
we
summarize
types
their
pharmacodynamic
effects,
finally
evaluate
use
modulate
relevant
targets
pathways,
providing
research
directions
for
summary,
problem
long-term
monotherapy
resistance
reduced
polyphenols,
while
incidence
toxic
side
effects.
addition,
inhibitors
identified
through
these
offering
avenues
pharmacological
treatment
multisite
fibrosis.
Язык: Английский
Metal-Dependent Cell Death in Renal Fibrosis: Now and in the Future
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13279 - 13279
Опубликована: Дек. 11, 2024
Renal
fibrosis
is
a
common
final
pathway
underlying
nearly
almost
all
progressive
kidney
diseases.
Metal
ions
are
essential
trace
elements
in
organisms
and
involved
important
physiological
activities.
However,
aberrations
intracellular
metal
ion
metabolism
may
disrupt
homeostasis,
causing
cell
death
increasing
susceptibility
to
various
Accumulating
evidence
suggests
complex
association
between
metal-dependent
renal
fibrosis.
In
this
article,
we
provide
comprehensive
overview
of
the
specific
molecular
mechanisms
their
crosstalk,
up-to-date
supporting
role
fibrosis,
therapeutic
targeting
strategies,
research
needs,
aiming
offer
rationale
for
future
clinical
treatment
Язык: Английский