Immunity Inflammation and Disease,
Год журнала:
2024,
Номер
12(8)
Опубликована: Авг. 1, 2024
Abstract
Background
Sirtuin
7
(SIRT7)
is
pivotal
in
diverse
diseases
progression.
Importantly,
SIRT7
associated
with
melanin
production.
However,
whether
regulates
vitiligo
unclear.
Therefore,
we
aimed
to
investigate
the
effects
of
on
pigmentation
and
modification
glucose
6‐phosphate
dehydrogenase
(G6PD).
Methods
After
knockdown
G6PD,
melanocytes
was
evaluated
using
commercial
kits,
immunofluorescence,
Western
blot
analysis.
The
succinylation
G6PD
mediated
by
analyzed
co‐immunoprecipitation,
analysis,
cycloheximide‐chase
experiment.
Results
We
found
that
highly
expressed
skin
lesions.
Knockdown
increased
tyrosinase
activity,
content,
levels
α‐melanocyte‐stimulating
hormone,
MITF,
TYR,
TRP1,
TRP2.
Additionally,
directly
interacted
G6PD.
Silenced
promoted
enhanced
its
protein
stability.
reversed
effect
reduced
expression
Conclsuion
Silencing
promotes
succinylating
suggesting
SIRT7‐mediated
desuccinylation
may
promote
Nutrients,
Год журнала:
2023,
Номер
15(21), С. 4697 - 4697
Опубликована: Ноя. 6, 2023
Vitiligo
is
a
common
autoimmune
skin
disease
caused
by
autoreactive
CD8+
T
cells.
The
diverse
effects
of
1,25-dihydroxyvitamin
D₃
[1,25(OH)₂D₃]
on
immune
cell
metabolism
and
proliferation
have
made
it
an
interesting
candidate
as
supporting
therapeutic
option
in
various
diseases.
This
study
aimed
to
elucidate
the
immunomodulatory
1,25(OH)₂D₃
vitiligo.
Cross-sectional
relationships
between
serum
levels
characteristics
were
investigated
327
patients
with
then
vivo
vitro,
respectively.
We
found
that
deficiency
was
associated
hyperactivity
cells
vitiligo
cohort.
In
addition,
suppressed
glycolysis
activating
AMP-activated
protein
kinase
(AMPK)
signaling
pathway,
thereby
inhibiting
proliferation,
cytotoxicity
aberrant
activation
Finally,
administration
melanocyte-associated
(MAV)
mice
reduced
infiltration
function
promoted
repigmentation.
conclusion,
may
serve
essential
biomarker
progression
severity
modulation
be
novel
approach
for
treating
Heliyon,
Год журнала:
2024,
Номер
10(2), С. e24843 - e24843
Опубликована: Янв. 1, 2024
Vitiligo
is
a
chronic
depigmentation
disease
caused
by
loss
of
functioning
melanocytes
and
melanin
from
the
epidermis.
Oxidative
stress-induced
damage
to
key
in
pathogenesis
vitiligo.
WSY6
caffeic
acid
derivative
synthesized
epigallocatechin-3-gallate
(EGCG).
This
study
investigate
whether
new
chemical
protected
H
Immunity Inflammation and Disease,
Год журнала:
2024,
Номер
12(8)
Опубликована: Авг. 1, 2024
Abstract
Background
Sirtuin
7
(SIRT7)
is
pivotal
in
diverse
diseases
progression.
Importantly,
SIRT7
associated
with
melanin
production.
However,
whether
regulates
vitiligo
unclear.
Therefore,
we
aimed
to
investigate
the
effects
of
on
pigmentation
and
modification
glucose
6‐phosphate
dehydrogenase
(G6PD).
Methods
After
knockdown
G6PD,
melanocytes
was
evaluated
using
commercial
kits,
immunofluorescence,
Western
blot
analysis.
The
succinylation
G6PD
mediated
by
analyzed
co‐immunoprecipitation,
analysis,
cycloheximide‐chase
experiment.
Results
We
found
that
highly
expressed
skin
lesions.
Knockdown
increased
tyrosinase
activity,
content,
levels
α‐melanocyte‐stimulating
hormone,
MITF,
TYR,
TRP1,
TRP2.
Additionally,
directly
interacted
G6PD.
Silenced
promoted
enhanced
its
protein
stability.
reversed
effect
reduced
expression
Conclsuion
Silencing
promotes
succinylating
suggesting
SIRT7‐mediated
desuccinylation
may
promote
