Drosophila melanogaster MLE Helicase Functions Beyond Dosage Compensation: Molecular Nature and Pleiotropic Effect of mle[9] Mutation

Russian Journal of Genetics, Год журнала: 2024, Номер 60(4), С. 460 - 470

Опубликована: Апрель 1, 2024

Язык: Английский

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The role of DEAD- and DExH-box RNA helicases in neurodevelopmental disorders

Frontiers in Molecular Neuroscience, Год журнала: 2024, Номер 17

Опубликована: Авг. 1, 2024

Neurodevelopmental disorders (NDDs) represent a large group of with an onset in the neonatal or early childhood period; NDDs include intellectual disability (ID), autism spectrum (ASD), attention deficit hyperactivity (ADHD), seizures, various motor disabilities and abnormal muscle tone. Among many underlying Mendelian genetic causes for these conditions, genes coding proteins involved all aspects gene expression pathway, ranging from transcription, splicing, translation to eventual RNA decay, feature rather prominently. Here we focus on two families helicases (DEAD- DExH-box helicases). Genetic variants several have recently been shown be associated NDD. We address constraints helicases, types pathological which discovered discuss biological pathways affected helicase are involved.

Язык: Английский

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Maf-family bZIP transcription factor NRL interacts with RNA-binding proteins and R-loops in retinal photoreceptors

eLife, Год журнала: 2024, Номер 13

Опубликована: Ноя. 15, 2024

RNA-binding proteins (RBPs) perform diverse functions including the regulation of chromatin dynamics and coupling transcription with RNA processing. However, our understanding their actions in mammalian neurons remains limited. Using affinity purification, yeast-two-hybrid proximity ligation assays, we identified interactions multiple RBPs neural retina leucine (NRL) zipper, a Maf-family factor critical for retinal rod photoreceptor development function. In addition to splicing, many NRL-interacting are associated R-loops, which form during increase maturation. Focusing on DHX9 helicase, demonstrate that its expression is modulated by NRL NRL-DHX9 interaction positively influenced R-loops. ssDRIP-Seq analysis reveals both stranded unstranded R-loops at distinct genomic elements, characterized active inactive epigenetic signatures enriched neuronal genes. binds types suggesting an epigenetically independent Our findings suggest additional highlight complex among factors, RBPs, regulating gene retina.

Язык: Английский

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Uncovering the Multifaceted Roles of DDX21: Bridging Biological Insights and Medical Applications

Journal of Bio-X Research, Год журнала: 2024, Номер 7

Опубликована: Янв. 1, 2024

DDX21 belongs to the DEAD-box (DDX) family of helicases but deviates from characteristic sequence Asp–Glu–Ala–Asp (DEAD) Asp–Glu–Val–Asp. In addition typical helicase activity associated with family, also possesses foldase and adenosine triphosphatase activities. It plays crucial roles in various molecular processes, including regulation transcription, ribosomal RNA processing, modification, unwinding spatial structures. is subject intricate by multiple upstream factors, expression control posttranslational modification. numerous cancer types, abnormal has been observed influence cell behaviors, such as cycle, proliferation, invasion, migration, apoptosis. addition, modulates innate immunity following viral infection a dual role process. This review comprehensively explores protein structure, regulatory mechanisms, pathophysiological functions DDX21. Consequently, this study not only offers potential avenues for future research sparks novel ideas targeted treatments both infections.

Язык: Английский

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<i>Drosophila melanogaster</i> MLE Helicase functions beyond dosage compensation: molecular nature and pleiotropic effect of <i>mle[9]</i>

Генетика, Год журнала: 2024, Номер 60(4), С. 34 - 46

Опубликована: Сен. 11, 2024

Язык: Английский

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