Bioengineering,
Год журнала:
2022,
Номер
9(7), С. 294 - 294
Опубликована: Июнь 30, 2022
Currently,
breast-cancer
treatment
has
a
number
of
adverse
side
effects
and
is
associated
with
poor
rates
progression-free
survival.
Therefore,
radiolabeled
anti-EpCAM
targeted
biomimetic
coated
nanocarrier
(EINP)
was
developed
in
this
study
to
overcome
some
the
challenges.
The
double
emulsion
method
synthesized
poly(lactic-co-glycolic
acid)
(PLGA)
nanoparticle
Na131I
entrapped
core.
PLGA
human
red
blood
cell
membranes
labeled
epithelial
adhesion
molecule
(EpCAM)
antibody
enable
it
target
EpCAM
overexpression
by
cells.
Characterization
determined
EINP
size
as
295
nm,
zeta
potential
−35.9
mV,
polydispersity
0.297.
radiochemical
purity
>95%.
Results
efficacy
against
positive
MCF-7
breast
cancer
at
24,
48,
72
h
were
69.11%,
77.84%,
74.6%,
respectively,
demonstrating
that
EINPs
achieved
greater
cytotoxic
supported
NIS-mediated
uptake
than
non-targeted
131INPs
Na131I.
In
comparison,
fibroblast
(EpCAM
negative)
treated
had
significantly
lower
cytotoxicity
(p
<
0.05).
Flow
cytometry
fluorescence
imaging
visually
signified
delivery
specifically
cells
result
targeting.
Additionally,
favorable
safety
profile,
hemolysis.
Pharmaceutics,
Год журнала:
2024,
Номер
16(4), С. 531 - 531
Опубликована: Апрель 12, 2024
Nanoparticle-based
drug
delivery
systems
hold
promise
for
cancer
treatment
by
enhancing
the
solubility
and
stability
of
anti-tumor
drugs.
Nonetheless,
challenges
inadequate
targeting
limited
biocompatibility
persist.
In
recent
years,
cell
membrane
nano-biomimetic
have
emerged
as
a
focal
point
research
development,
due
to
their
exceptional
traits,
including
precise
targeting,
low
toxicity,
good
biocompatibility.
This
review
outlines
categorization
advantages
bionic
nano-delivery
systems,
provides
an
introduction
preparation
methods,
assesses
applications
in
treatment,
chemotherapy,
gene
therapy,
immunotherapy,
photodynamic
photothermal
combination
therapy.
Notably,
delves
into
application
various
identifies
opportunities
future
advancement.
Embracing
membrane-coated
biomimetic
nanoparticles
presents
novel
unparalleled
avenue
personalized
tumor
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 17, 2025
We
report
the
assembly
of
poly(ethylene
glycol)
nanoparticles
(PEG
NPs)
and
optimize
their
surface
chemistry
to
minimize
formation
protein
coronas
immunogenicity
for
improved
biodistribution.
PEG
NPs
cross-linked
with
disulfide
bonds
are
synthesized
utilizing
zeolitic
imidazolate
framework-8
as
templates,
which
subsequently
modified
molecules
different
end
groups
(carboxyl,
methoxy,
or
amino)
vary
chemistry.
Among
modifications,
amino
residual
carboxyl
form
a
pair
zwitterionic
structures
on
NPs,
adsorption
proteins
(e.g.,
immunoglobulin,
complement
proteins)
maximize
blood
circulation
time.
The
influence
preexisting
antibodies
in
mice
pharmacokinetics
is
negligible,
demonstrates
resistance
anti-PEG
inhibition
accelerated
clearance
phenomenon.
This
research
highlights
importance
PEGylated
design
delivery
systems
reveals
translational
potential
cancer
therapy.
The
advent
of
immunotherapy
has
marked
a
new
era
in
cancer
treatment,
offering
significant
clinical
benefits.
Cell
membrane
as
drug
delivery
materials
played
crucial
role
enhancing
therapy
because
their
inherent
biocompatibility
and
negligible
immunogenicity.
Different
cell
membranes
are
prepared
into
nanovesicles
(CMNs),
but
CMNs
have
limitations
such
inefficient
targeting
ability,
low
efficacy,
unpredictable
side
effects.
Genetic
engineering
deepened
the
critical
immunotherapy,
enabling
genetically
engineered-CMN
(GCMN)-based
therapeutics.
To
date,
that
surface
modified
by
various
functional
proteins
been
developed
through
genetic
engineering.
Herein,
brief
overview
strategies
for
features
sources
is
discussed,
followed
description
GCMN
preparation
methods.
application
GCMNs
directed
at
different
immune
targets
addressed
challenges
prospects
translation.
Pharmaceutics,
Год журнала:
2023,
Номер
15(6), С. 1677 - 1677
Опубликована: Июнь 8, 2023
Achieving
precise
cancer
theranostics
necessitates
the
rational
design
of
smart
nanosystems
that
ensure
high
biological
safety
and
minimize
non-specific
interactions
with
normal
tissues.
In
this
regard,
“bioinspired”
membrane-coated
have
emerged
as
a
promising
approach,
providing
versatile
platform
for
development
next-generation
nanosystems.
This
review
article
presents
an
in-depth
investigation
into
potential
these
targeted
theranostics,
encompassing
key
aspects
such
cell
membrane
sources,
isolation
techniques,
nanoparticle
core
selection,
approaches
coating
cores
membrane,
characterization
methods.
Moreover,
underscores
strategies
employed
to
enhance
multi-functionality
nanosystems,
including
lipid
insertion,
hybridization,
metabolic
engineering,
genetic
modification.
Additionally,
applications
bioinspired
in
diagnosis
therapeutics
are
discussed,
along
recent
advances
field.
Through
comprehensive
exploration
provides
valuable
insights
their
theranostics.
Abstract
Cancer
immunotherapy
has
become
a
mainstream
cancer
treatment
over
traditional
therapeutic
modes.
cells
can
undergo
programmed
cell
death
including
ferroptosis,
pyroptosis,
autophagy,
necroptosis,
apoptosis
and
cuproptosis
which
are
find
to
have
intrinsic
relationships
with
host
antitumor
immune
response.
However,
direct
use
of
inducers
or
regulators
may
bring
about
severe
side
effects
that
also
be
rapidly
excreted
degraded
low
efficacy.
Nanomaterials
able
carry
them
for
long
circulation
time,
high
tumor
accumulation
controlled
release
achieve
satisfactory
effect.
Nowadays,
large
number
studies
focused
on
nanomedicines‐based
strategies
through
modulating
modalities
potentiate
immunity.
Herein,
types
their
function
first
summarized,
state‐of‐the‐art
research
progresses
in
nanomedicines
mediated
pathways
(e.g.,
cuproptosis)
response
provocation
highlighted.
Subsequently,
the
conclusion
outlook
potential
focus
discussed.
The
phenotypic
heterogeneity
of
circulating
tumor
cells
(CTCs)
and
the
nonspecific
adsorption
background
impede
effective
sensitive
detection
rare
CTCs.
Although
leukocyte
membrane
coating
approach
has
a
good
antileukocyte
adhesion
ability
holds
great
promise
for
addressing
challenge
capture
purity,
its
limited
specificity
sensitivity
prevent
use
in
heterogeneous
To
overcome
these
obstacles,
biomimetic
biosensor
that
integrated
dual-targeting
multivalent
aptamer/walker
duplex
functionalized
magnetic
beads
an
enzyme-powered
DNA
walker
signal
amplification
strategy
is
designed.
As
compared
to
conventional
coating,
achieves
efficient
high
purity
enrichment
CTCs
with
different
epithelial
cell
molecule
(EpCAM)
expression
while
minimizing
interference
leukocytes.
Meanwhile,
target
can
trigger
release
strands
activate
walker,
resulting
cascade
ultrasensitive
accurate
Importantly,
captured
remained
viable
be
recultured
vitro
success.
Overall,
this
work
provides
new
perspective
by
paves
way
early
cancer
diagnosis.
Medicinal Research Reviews,
Год журнала:
2024,
Номер
44(5), С. 2112 - 2193
Опубликована: Март 28, 2024
Abstract
Over
the
past
decade,
in
vivo
gene
replacement
therapy
has
significantly
advanced,
resulting
market
approval
of
numerous
therapeutics
predominantly
relying
on
adeno‐associated
viral
vectors
(AAV).
While
have
undeniably
addressed
several
critical
healthcare
challenges,
their
clinical
application
unveiled
a
range
limitations
and
safety
concerns.
This
review
highlights
emerging
challenges
field
therapy.
At
first,
we
discuss
both
role
biological
barriers
with
focus
AAVs,
current
landscape
human
We
delineate
advantages
disadvantages
AAVs
as
delivery
vehicles,
mostly
from
perspective
(hepatotoxicity,
cardiotoxicity,
neurotoxicity,
inflammatory
responses
etc.),
outline
mechanisms
adverse
events
response
to
AAV.
Contribution
every
aspect
AAV
(genomic
structure,
capsid
proteins)
host
injected
is
considered
substantiated
by
basic,
translational
studies.
The
updated
evaluation
recent
trials
medical
experience
clearly
shows
risks
that
sometimes
overshadow
hopes
for
curing
hereditary
disease.
last,
set
established
new
molecular
nanotechnology
tools
approaches
are
provided
potential
solutions
mitigating
or
eliminating
side
effects.
increasing
number
severe
reactions
and,
sadly
deaths,
demands
decisive
actions
resolve
issue
immune
extremely
high
doses
used
In
these
various
strategies
under
development,
including
aimed
at
augmenting
characteristics
others
focused
creating
secure
efficacious
non‐viral
vectors.
comprehensive
offers
an
overarching
present
state
utilizing
