Revista Ibero-Americana de Humanidades, Ciências e Educação,
Год журнала:
2024,
Номер
10(8), С. 2517 - 2523
Опубликована: Авг. 21, 2024
Neurosurgical
anesthesia
has
seen
significant
progress
with
the
introduction
of
biological
therapies,
particularly
monoclonal
antibodies
and
gene
therapy.
These
novel
treatments
hold
immense
potential
in
management
complex
neurological
conditions,
notably
brain
tumors
neurodegenerative
diseases.
The
promise
that
target
specific
antigens
as
adjuvant
therapies
for
aggressive
malignancies
like
glioblastoma,
therapy's
objective
to
correct
genetic
abnormalities
responsible
various
disorders,
are
noteworthy.
This
narrative
review
aims
provide
a
comprehensive
overview
current
research,
challenges,
future
directions
these
context
neurosurgical
anesthesia.
Journal of Neuroinflammation,
Год журнала:
2025,
Номер
22(1)
Опубликована: Фев. 7, 2025
Mitochondrial
dysfunction
is
a
pivotal
instigator
of
neuroinflammation,
with
mitochondrial
DNA
(mtDNA)
leakage
as
critical
intermediary.
This
review
delineates
the
intricate
pathways
leading
to
mtDNA
release,
which
include
membrane
permeabilization,
vesicular
trafficking,
disruption
homeostatic
regulation,
and
abnormalities
in
dynamics.
The
escaped
activates
cytosolic
sensors,
especially
cyclic
gmp-amp
synthase
(cGAS)
signalling
inflammasome,
initiating
neuroinflammatory
cascades
via
pathways,
exacerbating
spectrum
neurological
pathologies.
therapeutic
promise
targeting
discussed
detail,
underscoring
necessity
for
multifaceted
strategy
that
encompasses
preservation
homeostasis,
prevention
leakage,
reestablishment
dynamics,
inhibition
activation
sensors.
Advancing
our
understanding
complex
interplay
between
neuroinflammation
imperative
developing
precision
interventions
disorders.
Frontiers in Neurology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 29, 2024
Neuroinflammation
is
a
central
feature
in
the
pathophysiology
of
several
neurodegenerative
diseases,
including
MS,
AD,
and
PD.
This
review
aims
to
synthesize
current
research
on
role
inflammation
these
conditions,
emphasizing
potential
inflammatory
biomarkers
for
diagnosis
treatment.
We
highlight
recent
findings
mechanisms
neuroinflammation,
utility
disease
differentiation,
implications
therapeutic
strategies.
Advances
understanding
pathways
offer
promising
avenues
developing
targeted
interventions
improve
patient
outcomes.
Future
should
focus
validating
larger
cohorts
integrating
them
into
clinical
practice
enhance
diagnostic
accuracy
efficacy.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 1965 - 1965
Опубликована: Фев. 25, 2025
Neutrophils
play
a
key
role
in
inflammatory
responses
and
thrombosis,
but
their
complex
interactions
disease
pathogenesis
are
not
fully
understood.
This
review
examines
the
multifaceted
roles
of
neutrophils,
focusing
on
activation,
cytokine
release,
formation
neutrophil
extracellular
traps
(NETs),
which
contribute
to
host
defense
thrombosis.
We
discuss
interaction
between
inflammation
coagulation,
direct
effect
neutrophils
thrombus
stability,
involvement
pathological
thrombotic
diseases.
The
therapeutic
potential
drug
loading
treatment
as
well
clinical
implications
future
research
directions,
highlighted.
aim
this
is
gain
insight
into
critical
neutrophil-inflammation-thrombus
axis
its
target
for
diseases
suggest
possible
directions
neutrophil-loaded
therapy
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Апрель 1, 2025
Abstract
Few
studies
have
investigated
the
subcellular
effects
of
low
temperature
on
gene
expression
in
shrimp
and
most
other
crustaceans.
Before
analysis
is
conducted,
suitable
housekeeping
genes
(HKGs)
must
be
confirmed
to
account
for
differences
reverse
transcription
process
efficiency
among
samples.
Thus,
this
study
aimed
verify
five
frequently
used
HKGs,
namely
18S
ribosomal
RNA
(18S
rRNA),
ATPase,
histone
3,
β-actin,
glyceraldehyde
3-phosphate
dehydrogenase
(gapdh)
use
experiments
assessing
molecular-scale
cryopreservation
coral
banded
(
Stenopus
hispidus
)
embryos.
To
conduct
chilling
studies,
we
subjected
S.
embryos
incubation
at
either
26
°C
(control)
or
5
0,
4,
8,
16,
32
h.
The
software
tools
GeNorm,
NormFinder,
Bestkeeper
were
employed
identify
HKG.
GeNorm
identified
3
rRNA
as
stable
genes.
By
contrast,
NormFinder
determined
that
a
eye-formation
pre-hatch
stage
Finally,
gapdh
β-actin
are
This
first
HKGs
studying
temperatures.
Its
findings
can
aid
future
research
evaluating
Journal of Neuroscience Research,
Год журнала:
2025,
Номер
103(4)
Опубликована: Апрель 1, 2025
Central
nervous
system
(CNS)
disorders,
such
as
Alzheimer's
disease
(AD),
Parkinson's
(PD),
multiple
sclerosis
(MS),
and
migraines,
rank
among
the
most
prevalent
concerning
conditions
worldwide.
Despite
ongoing
research,
pathophysiology
of
these
disorders
remains
incompletely
understood,
primarily
due
to
their
complex
etiology.
Current
pharmacological
treatments
mainly
focus
on
alleviating
symptoms
rather
than
addressing
underlying
causes
diseases.
CNS
are
marked
by
impairments
in
neurocognitive
neuromuscular
functions,
cognitive
processes
like
learning
memory.
This
deterioration
not
only
impacts
quality
life
affected
individuals
but
also
places
a
significant
burden
families.
Neuroplasticity
is
key
property
that
enables
brain
repair
functional
recovery.
However,
neuroplasticity
often
compromised.
Neuroplasticity,
which
regulated
gene
expression,
modulated
environmental
factors
epigenetic
mechanisms,
thereby
reshaping
neuronal
networks
response
various
biological
stimuli
function.
Importantly,
plays
critical
role
repairing
brain,
especially
context
neurodegenerative
diseases,
where
damaged
neurons
can
reorganize
re-establish
lost
functions.
Targeting
mechanisms
holds
potential
for
developing
therapeutic
interventions
improve
treatment
outcomes
prevent
disorders.
A
deeper
understanding
neurological
diseases
could
open
new
avenues
enhancing
patient
life.
review
aims
provide
comprehensive
overview
synaptic
function
disrupted
