Molecules,
Год журнала:
2024,
Номер
29(16), С. 3784 - 3784
Опубликована: Авг. 9, 2024
Cancer
is
a
complex
disease
that
affects
millions
of
people
and
remains
major
public
health
problem
worldwide.
Conventional
cancer
treatments,
including
surgery,
chemotherapy,
immunotherapy,
radiotherapy,
have
limited
achievements
multiple
drawbacks,
among
which
are
healthy
tissue
damage
multidrug-resistant
phenotype
onset.
Increasing
evidence
shows
many
plants’
natural
products,
as
well
their
bioactive
compounds,
promising
anticancer
activity
exhibit
minimal
toxicity
compared
to
conventional
drugs.
However,
widespread
use
in
therapy
severely
restricted
by
limitations
terms
water
solubility,
absorption,
lack
stability,
bioavailability,
selective
targeting.
The
nanoformulations
for
product
transportation
delivery
could
be
helpful
overcoming
these
limitations,
thus
enhancing
therapeutic
efficacy
providing
the
basis
improved
treatment
strategies.
present
review
aimed
at
an
update
on
some
phytocompounds
(curcumin,
resveratrol,
quercetin,
cannabinoids,
others)
main
showing
antitumor
activities,
both
vitro
vivo,
against
such
different
human
types
breast
colorectal
cancer,
lymphomas,
malignant
melanoma,
glioblastoma
multiforme,
osteosarcoma.
intracellular
pathways
underlying
phytocompound
advantages
nanoformulation
employment
also
examined.
Finally,
this
critically
analyzes
research
gaps
causing
success
phytocompounds’
nanoformulations’
clinical
translation.
Pharmacological Research,
Год журнала:
2023,
Номер
190, С. 106733 - 106733
Опубликована: Март 15, 2023
Natural
compounds
are
widely
used
to
prevent
and
treat
various
diseases
due
their
antioxidant
anti-inflammatory
effects.
As
a
kind
of
promising
natural
compound,
plant-derived
exosome-like
nanoparticles
(PELNs)
extracted
from
multivesicular
bodies
edible
plants,
including
vegetables,
foods,
fruits,
mainly
regulate
the
cellular
immune
response
pathogen
attacks.
Moreover,
PELNs
could
remarkably
interfere
with
dynamic
imbalance
between
pro-inflammatory
effects,
facilitating
maintain
homeostasis
microenvironment.
may
serve
as
better
alternative
animal-derived
exosomes
(ADEs)
owing
widespread
sources,
cost-effectiveness,
easy
accessibility.
can
mediate
interspecies
communication
by
transferring
cargoes
such
proteins,
lipids,
nucleic
acids
plant
cells
mammalian
cells.
This
review
summarizes
biogenesis,
composition,
classification
exosomes;
common
separation,
purification,
characterization
methods
PELNs,
potential
advantages
over
ADEs;
immunomodulatory
functions
in
colitis,
cancer,
inflammation-associated
metabolic
diseases.
Additionally,
future
perspectives
challenges
associated
clinical
application
discussed.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 22, 2024
Melittin,
a
main
component
of
bee
venom,
is
cationic
amphiphilic
peptide
with
linear
α-helix
structure.
It
has
been
reported
that
melittin
can
exert
pharmacological
effects,
such
as
antitumor,
antiviral
and
anti-inflammatory
effects
in
vitro
vivo
.
In
particular,
may
be
beneficial
for
the
treatment
diseases
which
no
specific
clinical
therapeutic
agents
exist.
Melittin
effectively
enhance
properties
some
first-line
drugs.
Elucidating
mechanism
underlying
melittin-mediated
biological
function
provide
valuable
insights
application
disease
intervention.
However,
melittin,
positively
charged
amino
acids
enables
it
to
directly
punching
holes
cell
membranes.
The
hemolysis
red
cells
cytotoxicity
triggered
by
limit
its
applications.
Melittin-based
nanomodification,
immuno-conjugation,
structural
regulation
gene
technology
strategies
have
demonstrated
specificity,
reduce
off-target
cytolysis
suggests
potential
used
clinically.
This
article
summarizes
research
progress
on
antiviral,
antitumor
discusses
melittin-modification
future
applications
preventing
drug
resistance,
enhancing
selectivity
target
alleviating
cytotoxic
normal
cells.
Acta Materia Medica,
Год журнала:
2024,
Номер
3(2)
Опубликована: Янв. 1, 2024
Cancer
is
the
leading
cause
of
morbidity
and
mortality
worldwide
an
important
barrier
to
lengthening
life
expectancy
in
every
country.
Natural
products
are
receiving
increased
attention
from
researchers
globally
increasing
numbers
natural
approved
for
clinical
studies
involving
cancer
recent
years.
To
gain
more
insight
into
that
have
undergone
trials
treatment,
a
comprehensive
search
was
conducted.
The
https://clinicaltrials.gov
website
searched
relevant
product
information
up
December
2022.
terms
included
different
types
cancers,
such
as
colorectal,
lung,
breast,
gynecologic,
kidney,
bladder,
melanoma,
pancreatic,
hepatocellular,
gastric
haematologic.
Then,
PubMed
Web
Science
were
articles
February
2024.
Hence,
we
listed
existing
about
used
treatment
cancers
discussed
preclinical
some
promising
their
targets,
indications,
underlying
mechanisms
action.
Our
intent
provide
basic
readers
who
interested
or
majoring
obtain
deeper
understanding
progress
actions
European Journal of Medicinal Chemistry,
Год журнала:
2023,
Номер
261, С. 115820 - 115820
Опубликована: Сен. 14, 2023
Epigallocatechin
gallate
(EGCG)
is
a
polyphenol
present
in
green
tea
(Camellia
sinensis),
which
has
revealed
anti-cancer
effects
toward
variety
of
cancer
cells
vitro
and
protective
potential
against
neurodegenerative
diseases
such
as
Alzheimer's
Parkinson's.
Unfortunately,
EGCG
presents
disappointing
bioavailability
after
oral
administration,
primarily
due
to
its
chemical
instability
poor
absorption.
Due
these
limitations,
currently
not
used
medication,
but
only
dietary
supplement
the
form
extract.
Therefore,
it
needs
further
modifications
before
being
considered
suitable
for
extensive
medical
applications.
In
this
article,
we
review
scientific
literature
about
derivatives
focusing
on
their
biological
properties
The
most
common
epigallocatechin
rely
introducing
fatty
acid
chains
or
sugar
molecules
structure
modify
solubility.
Another
frequently
employed
procedure
based
blocking
EGCG's
hydroxyl
groups
with
various
substituents.
Novel
reveal
interesting
properties,
which,
antioxidant,
anti-inflammatory,
antitumor
antimicrobial,
are
especially
important.
It
worth
noting
that
promising
higher
stability
activity
than
base
EGCG.
Big Data and Cognitive Computing,
Год журнала:
2023,
Номер
7(2), С. 74 - 74
Опубликована: Апрель 13, 2023
One
of
the
three
most
serious
and
deadly
cancers
in
world
is
colorectal
cancer.
The
crucial
stage,
like
with
any
cancer,
early
diagnosis.
In
medical
industry,
artificial
intelligence
(AI)
has
recently
made
tremendous
strides
showing
promise
for
clinical
applications.
Machine
learning
(ML)
deep
(DL)
applications
have
gained
popularity
analysis
texts
images
due
to
benefits
achievements
they
diagnosis
cancerous
tissues
organs.
this
paper,
we
intend
systematically
review
state-of-the-art
research
on
AI-based
ML
DL
techniques
applied
modeling
All
papers
field
cancer
are
collected
based
techniques,
then
classified
into
categories:
aim
prediction,
method
data
samples.
Following
that,
a
thorough
summary
list
studies
gathered
under
each
topic
provided.
We
conclude
our
study
critical
discussion
challenges
opportunities
prediction
using
by
concentrating
technical
points
view.
Finally,
believe
that
will
be
helpful
scientists
who
considering
employing
methods
diagnose
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 5, 2024
Colorectal
cancer
is
the
third
most
common
type
of
worldwide
and
has
become
one
major
human
disease
burdens.
In
clinical
practice,
treatment
colorectal
been
closely
related
to
use
irinotecan.
Irinotecan
combines
with
many
other
anticancer
drugs
a
broader
range
drug
combinations.
Combination
therapy
important
means
improving
anti-tumor
efficacy
overcoming
resistance.
Reasonable
combination
can
lead
better
patient
options,
inappropriate
will
increase
risk.
For
therapeutic
field,
significance
improve
efficacy,
reduce
adverse
effects,
ease
treatment.
Therefore,
we
explored
advantages
its
based
on
mechanism
or
metabolism
reviewed
rationale
basis
limitations
in
conducting
exploratory
trials
irinotecan
therapy,
including
results
potentiation
cytotoxic
drugs,
targeted
agents,
herbal
medicine.
We
hope
that
these
evoke
more
efforts
conduct
laboratory
for
further
studies
evaluations,
as
well
possibility
in-depth
development
future
trials.
