Environmental and neurodevelopmental contributors to youth mental illness
Neuropsychopharmacology,
Год журнала:
2024,
Номер
50(1), С. 201 - 210
Опубликована: Июль 19, 2024
Abstract
While
a
myriad
of
factors
likely
contribute
to
the
development
mental
illness
in
young
people,
social
environment
(including
early
adverse
experiences)
concert
with
neurodevelopmental
alterations
is
undeniably
important.
A
number
influential
theories
make
predictions
about
how
and
why
may
mediate
or
moderate
effects
on
emergence
illness.
Here,
we
discuss
current
evidence
supporting
each
these
theories.
Although
this
area
research
rapidly
growing,
body
still
relatively
limited.
However,
there
exist
some
consistent
findings,
including
increased
striatal
reactivity
during
positive
affective
processing
larger
hippocampal
volumes
being
associated
vulnerability
susceptibility
environments
internalizing
symptoms.
Limited
longitudinal
work
has
investigated
mechanisms
linking
health.
Drawing
from
human
insights
animal
studies,
propose
an
integrated
mediation-moderation
model
outline
future
directions
advance
field.
Язык: Английский
Hippocampal subregion volumes and preadolescent depression risk in the ABCD sample
Journal of Affective Disorders,
Год журнала:
2025,
Номер
378, С. 165 - 174
Опубликована: Фев. 28, 2025
The
hippocampus
is
central
in
the
pathophysiology
of
depression.
Subregions
(head,
body,
tail)
have
been
implicated
adult
depression,
though
research
examining
depression
and
hippocampal
subregions
youth
has
limited.
This
study
aimed
to
examine
associations
between
preadolescent
risk
as
well
their
interactions
with
factors
associated
risk,
including
biological
sex
socioeconomic
status
(SES).
Hippocampal
were
extracted
from
Adolescent
Brain
Cognitive
Development
Study
baseline
sample
(N
=
10,469,
ages
9-10
years).
Depression
included
maternal
lifetime
child
depressive
symptoms,
internalizing
externalizing
symptoms.
Maternal
was
measured
through
Family
History
Questionnaire,
symptoms
Child
Behavioral
Checklist.
Results
identified
volumes
future
increases
9738).
Further,
moderated
by
SES:
males,
but
not
females,
exhibited
lower
tail
9826),
for
preadolescents
low,
high,
SES,
greater
head
predicted
increased
at
10,294)
24-month
follow
up
7069-7086).
Together,
this
demonstrates
importance
within
identifies
subgroups,
males
those
low
that
may
be
particular
risk.
Язык: Английский
Environmental and neurodevelopmental contributors to youth mental illness
Опубликована: Март 18, 2024
While
a
myriad
of
factors
likely
contribute
to
the
development
mental
illness
in
young
people,
social
environment
(including
early
adverse
experiences)
concert
with
neurodevelopmental
alterations
are
undeniably
important.
A
number
influential
theories
make
predictions
about
how
and
why
may
mediate
or
moderate
effects
on
emergence
illness.
Here,
we
discuss
current
evidence
supporting
each
these
theories.
Although
this
area
research
is
rapidly
growing,
body
still
relatively
limited.
However,
there
exist
some
consistent
findings,
including
increased
striatal
reactivity
during
positive
affective
processing
larger
hippocampal
volumes
being
associated
vulnerability
susceptibility
environments
internalizing
symptoms.
Limited
longitudinal
work
has
investigated
mechanisms
linking
health.
Drawing
from
human
insights
animal
studies,
propose
an
integrated
mediation-moderation
model
outline
future
directions
advance
field.
Язык: Английский
Macrostructural Brain Morphology as Moderator of the Relationship Between Pandemic-Related Stress and Internalizing Symptomology During COVID-19 in High-Risk Adolescents
Biological Psychiatry Cognitive Neuroscience and Neuroimaging,
Год журнала:
2024,
Номер
9(11), С. 1141 - 1177
Опубликована: Июль 15, 2024
According
to
person-by-environment
models,
individual
differences
in
traits
may
moderate
the
association
between
stressors
and
development
of
psychopathology;
however,
findings
literature
have
been
inconsistent
little
has
examined
adolescent
brain
structure
as
a
moderator
effects
stress
on
internalizing
symptoms.
The
COVID-19
pandemic
presented
unique
opportunity
examine
associations
stress,
structure,
psychopathology.
Given
links
cortical
morphology
with
depression
anxiety,
present
study
investigated
whether
moderates
relationship
from
symptoms
familial
high-risk
adolescents.
Prior
pandemic,
72
adolescents
(27M)
completed
measure
depressive
anxiety
underwent
magnetic
resonance
imaging.
T1-weighted
images
were
acquired
assess
thickness
surface
area.
Approximately
6-8
months
after
was
declared
global
reported
their
pandemic-related
stress.
Adjusting
for
pre-pandemic
increased
associated
but
not
This
moderated
by
area
anterior
cingulate
medial
orbitofrontal
cortex
such
that
only
among
lower
higher
these
regions.
Results
further
our
understanding
neural
vulnerabilities
general,
during
particular.
Язык: Английский