Jurnal Teknik Informatika (Jutif),
Год журнала:
2023,
Номер
4(6), С. 1339 - 1346
Опубликована: Дек. 23, 2023
The
spread
of
viruses
and
bacteria
through
touching
door
surfaces
is
essential
in
maintaining
public
hygiene
health.
In
this
context,
a
hand-coded
touchless
automatic
hardware
design
has
been
developed
to
reduce
the
diseases
touch.
This
research
aims
create
plan
that
includes
interface
development
open
close
doors
automatically
without
contact.
research,
response
tested
based
on
numeric
input
from
hand
code
represented
by
database.
output
control
connected
Python's
graphical
user
(GUI).
GUI
system
involves
tools
connect
Python
programming
language
Arduino
microcontroller.
Based
experimental
results,
security
Convolutional
Neural
Networks
functions
appropriately.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 1263 - 1263
Опубликована: Янв. 31, 2025
The
emergence
of
SARS-CoV-2
variants
has
significantly
impacted
the
global
response
to
COVID-19
pandemic.
This
review
examines
genetic
diversity
variants,
their
roles
in
epidemiological
tracking,
and
influence
on
viral
fitness.
Variants
concern
(VOCs)
such
as
Alpha,
Beta,
Gamma,
Delta,
Omicron
have
demonstrated
increased
transmissibility,
altered
pathogenicity,
potential
resistance
neutralizing
antibodies.
Epidemiological
tracking
these
is
crucial
for
understanding
spread,
informing
public
health
interventions,
guiding
vaccine
development.
also
explores
how
specific
mutations
spike
protein
other
genomic
regions
contribute
fitness,
affecting
replication
efficiency,
immune
escape,
transmission
dynamics.
By
integrating
surveillance
data
with
clinical
findings,
this
provides
a
comprehensive
overview
ongoing
evolution
its
implications
strategies
new
Journal of Water and Health,
Год журнала:
2024,
Номер
22(2), С. 401 - 413
Опубликована: Фев. 1, 2024
The
objective
of
this
study
was
to
assess
the
occurrence
and
seasonal
frequency
human
adenovirus
(HAdV),
polyomavirus
(HPyV),
papillomavirus
(HPV)
in
urban
sewage.
detection
these
viruses
carried
out
by
polymerase
chain
reaction
(PCR),
then
viral
concentrations
positive
samples
were
quantified
quantitative
PCR
(qPCR).
Additionally,
HAdV
HPyV
genotyping
also
performed
PCR.
A
total
38/60
(63.3%)
found.
most
prevalent
virus
(26/60;
43.3%),
followed
(21/60;
35%)
HPV
35%).
ranged
from
3.56
×
10
BACKGROUND
The
COVID-19
pandemic
requires
a
deep
understanding
of
SARS-CoV-2,
particularly
how
mutations
in
the
Spike
Receptor
Binding
Domain
(RBD)
Chain
E
affect
its
structure
and
function.
Current
methods
lack
comprehensive
analysis
these
at
different
structural
levels.
OBJECTIVE
To
analyze
impact
specific
associated
point
(N501Y,
L452R,
N440K,
K417N,
E484A)
on
SARS-CoV-2
RBD
function
using
predictive
modeling,
including
graph-theoretic
model,
protein
modeling
techniques,
molecular
dynamics
simulations.
METHODS
study
employed
multi-tiered
framework
to
represent
across
three
interconnected
This
model
incorporated
19
top-level
vertices,
connected
intermediate
graphs
based
6-angstrom
proximity
within
protein's
3D
structure.
Graph-theoretic
metrics
were
applied
weigh
vertices
edges
all
also
used
Iterative
Threading
Assembly
Refinement
(I-TASSER)
mutated
sequences
dynamic
simulation
(MD)
tools
evaluate
changes
folding
stability
compared
wildtype.
RESULTS
Three
distinct
analytical
approaches
successfully
identified
functional
(Chain
E)
resulting
from
mutations.
novel
detected
notable
changes,
with
N501Y
L452R
showing
most
pronounced
effects
conformation
stability.
K147N
E484A
demonstrated
less
significant
impacts.
Ab
initio
MD
findings
corroborated
analysis.
multi-level
approach
provided
visualization
mutation
effects,
deepening
our
their
consequences.
CONCLUSIONS
advanced
implications.
multi-faceted
characterized
various
mutations,
identifying
as
having
substantial
have
important
implications
for
vaccine
development,
therapeutic
design,
variant
monitoring.
research
underscores
power
combining
multiple
virology,
contributing
valuable
knowledge
ongoing
efforts
against
providing
future
studies
viral
impacts
The Science of The Total Environment,
Год журнала:
2024,
Номер
920, С. 170887 - 170887
Опубликована: Фев. 11, 2024
Co-presence
of
enveloped
and
non-enveloped
viruses
is
common
both
in
community
circulation
wastewater.
Community
surveillance
infections
requires
robust
methods
enabling
simultaneous
quantification
multiple
Using
SARS-CoV-2
Omicron
subvariants
Norovirus
(NoV)
as
examples,
this
study
reports
a
method
that
integrates
electronegative
membrane
(EM)
concentration,
viral
inactivation,
RNA
preservation
(VIP)
with
efficient
capture
enrichment
the
on
magnetic
(Mag)
beads,
direct
detection
beads.
This
provides
improved
recoveries
80
±
4
%
for
72
5
(Murine
NoV).
Duplex
reverse
transcription
quantitative
polymerase
chain
reaction
(RT-qPCR)
assays
newly
designed
degenerate
primer-probe
sets
offered
high
PCR
efficiencies
(90–91
%)
targets
NoV
(GI
GII)
were
able
to
detect
few
15
copies
per
reaction.
technique,
combined
multiplex
duplex
successfully
quantified
variants
same
94
influent
wastewater
samples
collected
from
two
large
systems
between
July
2022
June
2023.
The
results
showed
temporal
changes
revealing
an
inverse
relationship
their
emergence.
demonstrated
importance
analytical
platform
ability
sensitively
determine
pathogens
will
advance
applications
complementary
public
health
tool.
The
COVID-19
pandemic
has
revealed
significant
disparities
in
disease
severity
and
mortality
across
various
population
groups
regions.
These
cannot
be
attributed
solely
to
healthcare
systems,
socioeconomic
factors,
living
conditions,
or
individual
immune
landscapes;
environmental
factors
also
play
a
crucial
role.
This
work
explores
how
variations
nasal
morphology
related
age,
gender,
race
can
affect
the
respiratory
system's
ability
filter,
warm,
humidify
inhaled
air.
may
contribute
differences
cold,
dry,
polluted,
infected
air
impact
system,
thus
influencing
observed
patterns
of
outcomes.
analysis
suggests
that
individuals
with
genetically
determined
wider
cavities,
often
found
populations
originating
from
warmer
climates,
have
decreased
filtration
conditioning
efficiency,
leading
increased
susceptibility
infections
disproportionately
high
rates
COVID-19.
Moreover,
age-related
changes
morphology,
such
as
volume
involution
atrophy
mucosa,
impaired
filtration,
thereby
increasing
risk
severe
outcomes
elderly.
Gender
men
typically
having
larger
passages
compared
women,
are
linked
poorer
potentially
contributing
higher
men.
Preliminary
statistical
analyses
U.S.
suggest
favorable
structures
longer
life
expectancy
than
those
less
optimal
anatomy;
however,
this
should
regarded
hypothesis.
findings
underscore
gaps
our
understanding
highlight
urgent
need
for
further
research
unravel
complex
interplay
between
system
dynamics,
shaping
