Abstract
The
outbreak
of
coronavirus
disease
2019
(COVID‐19)
stimulates
a
body
studies
for
better
investigating
the
essential
mechanisms
and
clinical
characteristics
this
disease.
Notwithstanding,
underlying
multiple
organ
failure
(MOF)
remain
unclear.
Understanding
mechanism
COVID‐19‐stimulated
programmed
cell
death
(RCD)
may
contribute
to
strategies
these
patients.
Based
on
exploration
COVID‐19‐related
basic
science
reports
research,
we
speculate
that
ferroptosis,
recently
identified
RCD,
might
be
substantial
stimulator
MOF
in
COVID‐19,
it
act
as
novel
treatment
target.
However,
published
investigations
determine
how
ferroptosis
works
severe
acute
respiratory
syndrome
2
infection
are
still
lacking.
This
review
reveals
new
crucial
missing
links
our
prevailing
understanding
ferroptosis‐triggered
COVID‐19
We
also
specifically
summarize
several
literatures
evidence
about
functional
food
components
nutritional
supplement
by
its
inhibition.
hope
hypothesis
launch
wave
unveil
relationship
between
explore
more
ferroptosis‐related
daily
life
preventing
and/or
improve
outcome
during
therapy.
ACS Chemical Neuroscience,
Год журнала:
2023,
Номер
14(17), С. 2995 - 3012
Опубликована: Авг. 14, 2023
Ferroptosis
is
increasingly
being
recognized
as
a
key
element
in
the
pathogenesis
of
diverse
diseases.
Recent
studies
have
highlighted
intricate
links
between
iron
metabolism
and
neurodegenerative
disorders.
Emerging
evidence
suggests
that
homeostasis,
oxidative
stress,
neuroinflammation
all
contribute
to
regulation
both
ferroptosis
neuronal
health.
However,
precise
molecular
mechanisms
underlying
involvement
pathological
processes
neurodegeneration
its
impact
on
dysfunction
remain
incompletely
understood.
In
our
Review,
we
provide
comprehensive
analysis
summary
potential
diseases,
aiming
elucidate
disease
progression
neurodegeneration.
Additionally,
discuss
therapeutic
agents
modulate
with
goal
identifying
novel
drug
molecules
for
treatment
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Ноя. 9, 2023
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
is
considered
a
"multisystem"
that
simultaneously
suffers
from
metabolic
diseases
and
hepatic
steatosis.
Some
may
develop
into
fibrosis,
cirrhosis,
even
hepatocellular
carcinoma.
Given
the
close
connection
between
fatty
liver,
it
urgent
to
identify
drugs
can
control
as
whole
delay
progression.
Ferroptosis,
characterized
by
iron
overload
lipid
peroxidation
resulting
abnormal
metabolism,
programmed
cell
death
mechanism.
It
an
important
pathogenic
mechanism
in
or
become
key
direction
for
improving
MASLD.
In
this
article,
we
have
summarized
physiological
pathological
mechanisms
of
metabolism
ferroptosis,
well
connections
established
through
ferroptosis.
We
also
MASLD
therapeutic
potential
active
substances
targeting
order
provide
readers
with
new
insights.
At
same
time,
future
clinical
trials
involving
subjects
(especially
intervention
drugs),
detection
serum
levels
ferroptosis
markers
patients
should
be
increased
further
explore
efficacy
on
Abstract
The
outbreak
of
coronavirus
disease
2019
(COVID‐19)
stimulates
a
body
studies
for
better
investigating
the
essential
mechanisms
and
clinical
characteristics
this
disease.
Notwithstanding,
underlying
multiple
organ
failure
(MOF)
remain
unclear.
Understanding
mechanism
COVID‐19‐stimulated
programmed
cell
death
(RCD)
may
contribute
to
strategies
these
patients.
Based
on
exploration
COVID‐19‐related
basic
science
reports
research,
we
speculate
that
ferroptosis,
recently
identified
RCD,
might
be
substantial
stimulator
MOF
in
COVID‐19,
it
act
as
novel
treatment
target.
However,
published
investigations
determine
how
ferroptosis
works
severe
acute
respiratory
syndrome
2
infection
are
still
lacking.
This
review
reveals
new
crucial
missing
links
our
prevailing
understanding
ferroptosis‐triggered
COVID‐19
We
also
specifically
summarize
several
literatures
evidence
about
functional
food
components
nutritional
supplement
by
its
inhibition.
hope
hypothesis
launch
wave
unveil
relationship
between
explore
more
ferroptosis‐related
daily
life
preventing
and/or
improve
outcome
during
therapy.
