A Novel Ferroptosis-Related Gene Prognosis Signature and Identifying Atorvastatin as a Potential Therapeutic Agent for Hepatocellular Carcinoma
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(3), С. 201 - 201
Опубликована: Март 18, 2025
Among
the
most
common
malignant
tumors,
hepatocellular
carcinoma
(HCC)
is
a
primary
liver
cancer
type
that
has
high
mortality
rate.
HCC
often
presents
insidiously,
prone
to
recurrence,
and
limited
treatment
efficacy.
Ferroptosis
regulates
tumorigenesis,
progression,
metastasis,
which
novel
form
of
iron-dependent
cell
death.
Numerous
studies
suggest
sensitive
ferroptosis,
indicating
targeted
therapies
aimed
at
inducing
ferroptosis
may
represent
promising
new
approach
treatment.
This
study
aims
find
genes
associated
with
as
well
screen
for
potential
agents
cause
in
HCC.
Transcriptome
clinical
sample
data
were
obtained
from
TCGA
database
identify
differentially
expressed
related
ferroptosis.
Using
various
regression
survival
analysis
techniques,
we
developed
prognostic
model
based
on
four
core
evaluated
its
predictive
potential.
Subsequently,
screened
therapeutic
Connective
Map
(CMap)
database,
designated
compound
Atorvastatin,
differential
two
risk
groups
Through
experiments
conducted
vivo
vitro,
demonstrated
Atorvastatin
can
induce
cells
while
inhibiting
their
growth
migration.
In
conclusion,
this
research
targets
therapy
provides
insights
improving
prediction
prevention
Язык: Английский
Recent Advances on the Role of B Vitamins in Cancer Prevention and Progression
Zachary Frost,
Sandra Bakhit,
Chelsea N. Amaefuna
и другие.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 1967 - 1967
Опубликована: Фев. 25, 2025
Water-soluble
B
vitamins,
mainly
obtained
through
dietary
intake
of
fruits,
vegetables,
grains,
and
dairy
products,
act
as
co-factors
in
various
biochemical
processes,
including
DNA
synthesis,
repair,
methylation,
energy
metabolism.
These
vitamins
include
B1
(Thiamine),
B2
(Riboflavin),
B3
(Niacin),
B5
(Pantothenic
Acid),
B6
(Pyridoxine),
B7
(Biotin),
B9
(Folate),
B12
(Cobalamin).
Recent
studies
have
shown
that
besides
their
fundamental
physiological
roles,
influence
oncogenic
metabolic
pathways,
glycolysis
(Warburg
effect),
mitochondrial
function,
nucleotide
biosynthesis.
Although
deficiencies
these
are
associated
with
several
complications,
emerging
evidence
suggests
excessive
specific
may
also
contribute
to
cancer
progression
interfere
therapy
due
impaired
genetic
functions.
This
review
discusses
the
tumor-suppressive
tumor-progressive
roles
cancer.
It
explores
recent
on
a
comprehensive
understanding
relationship
between
vitamin
metabolism
underscores
need
for
further
research
determine
optimal
balance
prevention
therapy.
Язык: Английский
MCM4 potentiates evasion of hepatocellular carcinoma from sorafenib-induced ferroptosis through Nrf2 signaling pathway
International Immunopharmacology,
Год журнала:
2024,
Номер
142, С. 113107 - 113107
Опубликована: Сен. 13, 2024
Язык: Английский
The Role of Mitochondrial Solute Carriers SLC25 in Cancer Metabolic Reprogramming: Current Insights and Future Perspectives
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
26(1), С. 92 - 92
Опубликована: Дек. 26, 2024
Cancer
cells
undergo
remarkable
metabolic
changes
to
meet
their
high
energetic
and
biosynthetic
demands.
The
Warburg
effect
is
the
most
well-characterized
alteration,
driving
cancer
catabolize
glucose
through
aerobic
glycolysis
promote
proliferation.
Another
prominent
hallmark
of
increased
reliance
on
glutamine
replenish
tricarboxylic
acid
(TCA)
cycle
intermediates
essential
for
ATP
production,
aspartate
fatty
synthesis,
maintaining
redox
homeostasis.
In
this
context,
mitochondria,
which
are
primarily
used
maintain
energy
homeostasis
support
balanced
biosynthesis
in
normal
cells,
become
central
organelles
fulfilling
heightened
demands
proliferating
cells.
Mitochondrial
coordination
metabolite
exchange
with
other
cellular
compartments
crucial.
human
SLC25
mitochondrial
carrier
family,
comprising
53
members,
plays
a
pivotal
role
transporting
TCA
intermediates,
amino
acids,
vitamins,
nucleotides,
cofactors
across
inner
membrane,
thereby
facilitating
cross-talk.
Numerous
studies
have
demonstrated
that
carriers
altered
actively
contributing
tumorigenesis.
This
review
comprehensively
discusses
pathogenesis
reprogramming
based
current
experimental
evidence.
It
also
highlights
research
gaps
need
be
addressed
future
studies.
Understanding
involvement
these
tumorigenesis
may
provide
valuable
novel
targets
drug
development.
Язык: Английский