Advances in Clinical Medicine, Год журнала: 2024, Номер 14(08), С. 34 - 40
Опубликована: Янв. 1, 2024
Язык: Английский
Pharmacological Research, Год журнала: 2024, Номер unknown, С. 107419 - 107419
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
4
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Окт. 21, 2024
In recent years, cancer, especially primary liver cancer (including hepatocellular carcinoma and intrahepatic cholangiocarcinoma), has posed a serious threat to human health. the field of exosomes play an important role in initiation, metastasis interaction with tumor microenvironment. Exosomes are class nanoscale extracellular vesicles (EVs)secreted by most cells rich bioactive molecules, including RNA, proteins lipids, that mediate intercellular communication during physiological pathological processes. This review reviews multiple roles progression, as well their effects on angiogenesis, epithelial-mesenchymal transformation (EMT), immune evasion, drug resistance. have great potential biomarkers for diagnosis prognosis because they carry specific molecular markers facilitate early detection evaluation treatment outcomes. addition, exosomes, new type delivery vector, unique advantages targeted therapy provide strategy cancer. The challenges prospects exosome-based immunotherapy were also discussed. However, such standardization isolation techniques scalability therapeutic applications remain significant hurdles.
Язык: Английский
Процитировано
3
Cellular Oncology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 10, 2025
Язык: Английский
Процитировано
0
Stem Cell Reviews and Reports, Год журнала: 2025, Номер unknown
Опубликована: Март 17, 2025
Язык: Английский
Процитировано
0
Journal of Biological Chemistry, Год журнала: 2025, Номер unknown, С. 108528 - 108528
Опубликована: Апрель 1, 2025
Protein homeostasis is primarily regulated by post-translational modifications (PTMs). HIPK3 has been recognized as a tumor suppressor across various cancers. However, the impact of PTMs on remains insufficiently explored. This study identified WWP1 an E3 ubiquitin ligase targeting HIPK3, demonstrating that downregulates protein levels facilitating its ubiquitination. Mechanistically, directly interacts with promoting K48-linked polyubiquitination at K1187 site. The WWP1/HIPK3 axis modulates cancer cell chemosensitivity through regulation JNK signaling pathway. Additionally, Myc was found to act transcription factor, enhancing expression. These findings offer novel insights into PTM level.
Язык: Английский
Процитировано
0
Mitochondrion, Год журнала: 2025, Номер 84, С. 102045 - 102045
Опубликована: Апрель 24, 2025
Язык: Английский
Процитировано
0
Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13
Опубликована: Май 14, 2025
Hepatoblastoma (HB), the most common pediatric liver malignancy, is characterized by aggressive growth and metastasis driven complex angiogenic mechanisms. This review elucidates pivotal role of angiogenesis in HB progression, emphasizing metabolic reprogramming, tumor microenvironment (TME) dynamics, oncogenic signalling pathways. The Warburg effect cells fosters a hypoxic microenvironment, stabilizing hypoxia-inducible factor-1α (HIF-1α) upregulating vascular endothelial factor (VEGF), which synergistically enhances angiogenesis. Key pathways such as Wnt/β-catenin, VEGF, PI3K/AKT, JAK2/STAT3 are central to cell proliferation, migration, maturation, whereas interactions with tumor-associated macrophages (TAMs) pericytes further remodel TME support neovascularization. Long noncoding RNAs glycolytic enzymes have emerged critical regulators angiogenesis, linking activity expansion. Anti-angiogenic therapies, including VEGF inhibitors pathway-targeting agents, show preclinical promise but face challenges resistance off-target effects. Future directions advocate for dual-target strategies, spatial multiomics technologies map metabolic–angiogenic crosstalk, personalized approaches leveraging biomarkers risk stratification. synthesis underscores need interdisciplinary collaboration translate mechanistic insights into durable ultimately improving outcomes patients.
Язык: Английский
Процитировано
0
Cell Death Discovery, Год журнала: 2025, Номер 11(1)
Опубликована: Май 17, 2025
This study aims to explore the molecules that affect survival of Human Umbilical Vein Endothelial Cells (HUVECs) under hypoxia and their mechanisms action. In hypoxia, plasmolipin (PLLP) was identified through screening CRISPR/Cas9 small guide RNA (sgRNA) library. Functionally, PLLP knockout led increase cell proliferation, cellular metabolism, tight junction formation, angiogenesis ability, migration invasion in hypoxic HUVECs. Furthermore, countered inhibitory effects bevacizumab on HUVECs conditions. found modulate by enhancing phosphorylation AKT ERK1/2 proteins. conclusion, inhibiting expression promotes maintenance functions condition. plays a crucial role regulating activation pathways. identifies novel conditions provides new possibility for future studies
Язык: Английский
Процитировано
0
Stem Cell Reviews and Reports, Год журнала: 2025, Номер unknown
Опубликована: Май 24, 2025
Язык: Английский
Процитировано
0
Frontiers in Bioscience-Landmark, Год журнала: 2024, Номер 29(5)
Опубликована: Май 15, 2024
Background: It has been demonstrated that exosomes derived from HPV-16 E7-over-expressiong non-small cell lung cancer (NSCLC) cells (E7 Exo) trigger increased levels of epidermal growth factor receptor (EGFR) and miR-381-3p. The purpose this investigation was to examine the role E7 Exo in NSCLC angiogenesis, analyze contribution exosomal EGFR miR-381-3p it. Methods: influence on proliferation migration human umbilical vein endothelial (HUVECs) assessed using colony formation transwell assays. Experiments both animal models were conducted evaluate angiogenic effect treatment. involvement angiogenesis further investigated through suppressing exosome release or activation, by over-expressing Results: Treatment with proliferation, migration, tube capacities HUVECs, as well models. suppression activation decreased E7-induced enhancements HUVEC formation, notably reduced vascular A (VEGFA) Ang-1 levels. HUVECs combined mimic transfection treatment exhibited a more significant tube-forming capacity than Exo-treated alone, but reversed inhibitor. Conclusion: induced is mediated
Язык: Английский
Процитировано
2