Advanced Therapeutics,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 9, 2024
Abstract
Glucose‐derived
carbon
nanospheres
(CSP),
uniquely
derived
by
hydrothermal
condensation
process,
inherently
cross
blood–brain‐barrier
(BBB)
but
distribute
all
over
the
brain.
Albeit
its
potential
to
treat
glioma
as
an
effective
drug
delivery
system,
it
is
challenging
restrict
drug‐associated
CSP
within
region
and
reduce
non‐specific
side
effects.
Incidentally,
gliomas
moderately
express
sigma
receptors
(SR).
Earlier,
a
cationic
lipid‐conjugated
neuropsychotic
drug,
haloperidol
(H8)
developed
with
SR‐targetability
anticancer
effect
zero
BBB‐crossing
ability.
In
this
study,
surface
modified
H8
(CH8
nano‐conjugate)
dual
targeting
achieved
glioma‐tumor
microenvironment:
1)
cells
2)
pro‐proliferative
M2
tumor‐associated
macrophages
(TAM),
both
SR.
CH8‐treatment
increases
survivability
of
orthotopic
bearing
mice
significantly
reduces
tumor
burden
in
glioma‐subcutaneous
model.
Further
CH8‐surface
combining
brain
carmustine
(CH8‐CRM).
CH8‐CRM
nano‐conjugate
selectively
enhances
glioma‐carrying
aggressiveness
comparison
other
treatment
groups.
Lysates
from
CH8‐CRM‐treated
show
upregulation
cleaved‐caspase
3,
p53,
downregulation
pAkt.
The
combination
pronouncedly
anti‐glioma
H8.
Conclusively,
CH8‐mediated
dual‐targeting
via
SR
glioma‐associated
exemplifies
repurposing
drugs
for
treating
glioma.
Journal of Functional Biomaterials,
Год журнала:
2025,
Номер
16(3), С. 110 - 110
Опубликована: Март 20, 2025
We
are
committed
to
writing
this
narrative
review
given
that
carbon-based
nanomaterials
revolutionizing
dental
medicine.
Since
the
groundbreaking
discovery
of
carbon
nanotubes
in
1991,
their
applications
have
skyrocketed.
The
numbers
speak
for
themselves:
2024,
global
market
hit
USD
1.3
billion
and
is
set
double
2.6
by
2029.
Over
past
few
decades,
various
forms
been
integrated
into
practices,
elevating
quality
effectiveness
treatments.
They
represent
a
transformative
advancement
dentistry,
offering
numerous
benefits
such
as
augmented
mechanical
properties,
antimicrobial
activity,
potential
regenerative
applications.
Both
(CNTs)
dots
(CDs)
derived
from
integral
nanotechnology,
showcasing
versatility
nanostructures
delivering
cutting-edge
solutions
across
diverse
domains,
electronics,
materials
science,
biomedicine.
CNTs
ambitiously
examined
capability
reinforce
materials,
develop
biosensors
detecting
oral
diseases,
even
deliver
therapeutic
agents
directly
affected
tissues.
This
synthesizes
current
applications,
underscores
interdisciplinary
value
bridging
nanotechnology
identifies
key
barriers
clinical
adoption,
discusses
hybrid
strategies
warranting
further
research
advance
implementation.
