Depression in young people

The Lancet, Год журнала: 2022, Номер 400(10352), С. 617 - 631

Опубликована: Авг. 1, 2022

Язык: Английский

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Mental health in UK Biobank – development, implementation and results from an online questionnaire completed by 157 366 participants: a reanalysis

BJPsych Open, Год журнала: 2020, Номер 6(2)

Опубликована: Фев. 6, 2020

Background UK Biobank is a well-characterised cohort of over 500 000 participants including genetics, environmental data and imaging. An online mental health questionnaire was designed for to expand its potential. Aims Describe the development, implementation results this questionnaire. Method expert working group questionnaire, using established measures where possible, consulting patient group. Operational criteria were agreed defining likely disorder risk states, lifetime depression, mania/hypomania, generalised anxiety disorder, unusual experiences self-harm, current post-traumatic stress hazardous/harmful alcohol use. Results A total 157 366 completed questionnaires available by August 2017. Participants aged 45–82 (53% ≥65 years) 57% women. Comparison self-reported diagnosed with contemporary study shows similar prevalence, despite respondents being higher average socioeconomic status. Lifetime depression common finding, 24% (37 434) meeting use met 21% (32 602), whereas other less than 8% participants. There extensive comorbidity among syndromes. Mental disorders associated high neuroticism score, adverse life events long-term illness; addiction bipolar affective in particular deprivation. Conclusions The represents very large survey itself, presented here show face validity, although caution needed because selection bias. Built into Biobank, these intersect offer unparalleled potential crosscutting biomedical research involving health.

Язык: Английский

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Minimal phenotyping yields genome-wide association signals of low specificity for major depression

Nature Genetics, Год журнала: 2020, Номер 52(4), С. 437 - 447

Опубликована: Март 30, 2020

Язык: Английский

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RETRACTED – Mental health in UK Biobank: development, implementation and results from an online questionnaire completed by 157 366 participants

BJPsych Open, Год журнала: 2018, Номер 4(3), С. 83 - 90

Опубликована: Апрель 3, 2018

Background UK Biobank is a well-characterised cohort of over 500 000 participants that offers unique opportunities to investigate multiple diseases and risk factors. Aims An online mental health questionnaire completed by was expected expand the potential for research into disorders. Method expert working group designed questionnaire, using established measures where possible, consulting with patient regarding acceptability. Case definitions were defined operational criteria lifetime depression, mania, anxiety disorder, psychotic-like experiences self-harm, as well current post-traumatic stress alcohol use Results 157 366 questionnaires available August 2017. Comparison self-reported diagnosed disorder contemporary study shows similar prevalence, despite respondents being higher average socioeconomic status than general population across range indicators. Thirty-five per cent (55 750) had at least one syndrome, which depression most common 24% (37 434). There extensive comorbidity among syndromes. Mental disorders associated high neuroticism score, adverse life events long-term illness; addiction bipolar affective in particular deprivation. Conclusions The represents very large survey itself, results presented here show face validity, although caution needed owing selection bias. Built Biobank, these data intersect other offer unparalleled crosscutting biomedical involving health. Declaration interest G.B. received grants from National Institute Health Research during study; support Illumina Ltd. European Commission outside submitted work. B.C. Scottish Executive Chief Scientist Office Dr Mortimer Theresa Sackler Foundation study. C.S. Medical Council Wellcome Trust study, Biobank. M.H. Innovative Medicines Initiative via RADAR-CNS programme personal fees an witness

Язык: Английский

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Dissecting diagnostic heterogeneity in depression by integrating neuroimaging and genetics

Neuropsychopharmacology, Год журнала: 2020, Номер 46(1), С. 156 - 175

Опубликована: Авг. 11, 2020

Язык: Английский

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An Exposure-Wide and Mendelian Randomization Approach to Identifying Modifiable Factors for the Prevention of Depression

American Journal of Psychiatry, Год журнала: 2020, Номер 177(10), С. 944 - 954

Опубликована: Авг. 14, 2020

Efforts to prevent depression, the leading cause of disability worldwide, have focused on a limited number candidate factors. Using phenotypic and genomic data from over 100,000 UK Biobank participants, authors sought systematically screen validate wide range potential modifiable factors for depression.

Язык: Английский

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Major Depression: One Brain, One Disease, One Set of Intertwined Processes

Cells, Год журнала: 2021, Номер 10(6), С. 1283 - 1283

Опубликована: Май 21, 2021

Major depressive disorder (MDD) is a heterogeneous disease affecting one out of five individuals and the leading cause disability worldwide. Presently, MDD considered multifactorial with various causes such as genetic susceptibility, stress, other pathological processes. Multiple studies allowed formulation several theories attempting to describe development MDD. However, none these hypotheses are comprehensive because them can explain all cases, mechanisms, symptoms Nevertheless, share some common pathways, which lead us believe that depict pieces same big puzzle. Therefore, in this review, we provide brief description their strengths weaknesses an attempt highlight mechanisms relationships major depression combine together present current overall picture. The analysis suggests there interdependence between brain structures substances involved pathogenesis MDD, could be not entirely universal, but affect regions, degree or another, depending on triggering factor, which, turn, different subtypes

Язык: Английский

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The genetic basis of major depressive disorder

Molecular Psychiatry, Год журнала: 2023, Номер 28(6), С. 2254 - 2265

Опубликована: Янв. 26, 2023

The genetic dissection of major depressive disorder (MDD) ranks as one the success stories psychiatric genetics, with genome-wide association studies (GWAS) identifying 178 risk loci and proposing more than 200 candidate genes. However, GWAS results derive from analysis cohorts in which most cases are diagnosed by minimal phenotyping, a method that has low specificity. I review data indicating there is large component unique to MDD remains inaccessible phenotyping strategies majority identified approaches unlikely be loci. show inventive uses biobank data, novel imputation methods, combined interviewer cases, can identify contribute episodic severe shifts mood, neurovegetative cognitive changes central MDD. Furthermore, new theories about nature causes MDD, drawing upon advances neuroscience psychology, provide handles on how best interpret exploit mapping results.

Язык: Английский

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Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids

Biological Psychiatry, Год журнала: 2023, Номер 94(8), С. 630 - 639

Опубликована: Фев. 9, 2023

Язык: Английский

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Causes and Consequences of Diagnostic Heterogeneity in Depression: Paths to Discovering Novel Biological Depression Subtypes

Biological Psychiatry, Год журнала: 2020, Номер 88(1), С. 83 - 94

Опубликована: Янв. 28, 2020

Язык: Английский

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