Herein
we
report
the
regioselective
cyanation
of
isatogen
(3-indolone
N-oxide)
and
its
derivatives.
The
high
electrophilicity
is
a
key
feature
for
their
various
chemical
transformations,
describe
new
application
to
use
boron
catalyst
regio-
stereoselective
at
C2
position
isatogen.
combination
B(C6F5)3
Me3SiCN
optimal,
C2-cyano
adducts
are
exclusively
obtained
in
up
quantitative
yield.
In
addition,
isatogenol
that
includes
tertiary
hydroxyl
group
C3
also
suitable
this
create
consecutive
tetra-substituted
carbons
with
stereoselectivity.
