Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

Advanced Materials, Год журнала: 2020, Номер 32(47)

Опубликована: Окт. 16, 2020

Ultrasound (US)-triggered sonodynamic therapy (SDT), as a promising noninvasive therapeutic modality, has received ever-increasing attention in recent years. Its specialized chemical agents, named sonosensitizers, are activated by low-intensity US to produce lethal reactive oxygen species (ROS) for oncotherapy. Compared with phototherapeutic strategies, SDT provides many noteworthy opportunities and benefits, such deeper penetration depth, absence of phototoxicity, fewer side effects. Nevertheless, previous studies have also demonstrated its intrinsic limitations. Thanks the facile engineering nature nanotechnology, numerous novel nanoplatforms being applied this emerging field tackle these barriers achieve continuous innovations. In particular, combination other treatment strategies superior efficacy improving anticancer activity relative that monotherapies alone. Therefore, it is necessary summarize nanomaterial-assisted combinational cancer applications. Herein, design principles achieving synergistic effects based on nanomaterial methods highlighted. The ultimate goals stimulate better-quality combined schemes provide innovative ideas perspectives promoting future transformation clinical application.

Язык: Английский

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Solutions to the Drawbacks of Photothermal and Photodynamic Cancer Therapy

Advanced Science, Год журнала: 2021, Номер 8(3)

Опубликована: Янв. 5, 2021

Phototherapy such as photothermal therapy and photodynamic in cancer treatment has been developed quickly over the past few years for its noninvasive nature high efficiency. However, there are still many drawbacks phototherapy that prevent it from clinical applications. Thus, scientists have designed different systems to overcome issues associated with phototherapy, including enhancing targeting ability of low-temperature therapy, replacing near-infrared light other excitation sources, so on. This article discusses problems shortcomings encountered development highlights possible solutions address them may become a useful approach practice. aims give brief summary about current research advancements provides quick guideline toward future developments field.

Язык: Английский

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Targeting immunogenic cancer cell death by photodynamic therapy: past, present and future

Journal for ImmunoTherapy of Cancer, Год журнала: 2021, Номер 9(1), С. e001926 - e001926

Опубликована: Янв. 1, 2021

The past decade has witnessed major breakthroughs in cancer immunotherapy. This development been largely motivated by cell evasion of immunological control and consequent tumor resistance to conventional therapies. Immunogenic death (ICD) is considered one the most promising ways achieve total elimination. It activates T-cell adaptive immune response results formation long-term memory. ICD can be triggered many anticancer treatment modalities, including photodynamic therapy (PDT). In this review, we first discuss role PDT based on several classes photosensitizers, porphyrins non-porphyrins, critically evaluate their potential induction. We emphasize emerging trend induction combination with nanotechnology, which represents third-generation photosensitizers involves targeted PDT. However, also some limitations, reduced efficiency hypoxic microenvironment. Therefore, strategies for overcoming limitation, essential increasing efficiency. final part, suggest areas future research personalized immunotherapy, oxygen-boosted nanoparticles. conclusion, insights from last years increasingly support idea that a powerful strategy inducing experimental therapy. studies have focused mouse models, but it necessary validate clinical settings, will challenging area future.

Язык: Английский

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Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy

Theranostics, Год журнала: 2021, Номер 12(1), С. 434 - 458

Опубликована: Дек. 15, 2021

Cancer immunotherapy has made tremendous clinical progress in advanced-stage malignancies. However, patients with various tumors exhibit a low response rate to because of powerful immunosuppressive tumor microenvironment (TME) and insufficient immunogenicity tumors. Photodynamic therapy (PDT) can not only directly kill cells, but also elicit immunogenic cell death (ICD), providing antitumor immunity. Unfortunately, limitations from the inherent nature complex TME significantly reduce efficiency PDT. Recently, smart nanomedicine-based strategies could subtly modulate pharmacokinetics therapeutic compounds optimize both PDT immunotherapy, resulting an improved effect. Here, emerging nanomedicines for PDT-driven cancer are reviewed, including hypoxia-reversed nanomedicines, nanosized metal-organic frameworks, subcellular targeted nanoparticles (NPs). Moreover, we highlight synergistic nanotherapeutics used amplify immune responses combined against Lastly, challenges future expectations field discussed.

Язык: Английский

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Nanomedicine in cancer therapy

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Авг. 7, 2023

Cancer remains a highly lethal disease in the world. Currently, either conventional cancer therapies or modern immunotherapies are non-tumor-targeted therapeutic approaches that cannot accurately distinguish malignant cells from healthy ones, giving rise to multiple undesired side effects. Recent advances nanotechnology, accompanied by our growing understanding of biology and nano-bio interactions, have led development series nanocarriers, which aim improve efficacy while reducing off-target toxicity encapsulated anticancer agents through tumor tissue-, cell-, organelle-specific targeting. However, vast majority nanocarriers do not possess hierarchical targeting capability, their indices often compromised poor accumulation, inefficient cellular internalization, inaccurate subcellular localization. This Review outlines current prospective strategies design organelle-targeted nanomedicines, highlights latest progress technologies can dynamically integrate these three different stages static maximize outcomes. Finally, we briefly discuss challenges future opportunities for clinical translation nanomedicines.

Язык: Английский

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Ultrasound-Augmented Mitochondrial Calcium Ion Overload by Calcium Nanomodulator to Induce Immunogenic Cell Death

Nano Letters, Год журнала: 2021, Номер 21(5), С. 2088 - 2093

Опубликована: Фев. 17, 2021

Immunogenic cell death (ICD), a manner of tumor that can trigger antitumor immune responses, has received extensive attention as potential synergistic modality for cancer immunotherapy. Although many calcium ion (Ca2+) nanomodulators have been developed therapy through mitochondrial Ca2+ overload, their ICD-inducing properties not explored. Herein, an acid-sensitive PEG-decorated carbonate (CaCO3) nanoparticle incorporating curcumin (CUR; enhancer) (PEGCaCUR) was prepared using simple one-pot strategy. PEGCaCUR served only nanomodulator inducing efficient overload but also ICD inducer during improved therapy. Combination with ultrasound (US), PEGCaCUR+US, led to enhanced effect attributable the along subsequent upregulation reactive oxygen species levels. facilitates photoacoustic/fluorescence dual-mode imaging, well effectively suppressing growth and metastasis, indicating promising theranostic properties.

Язык: Английский

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Tumor‐Microenvironment‐Responsive Nanomedicine for Enhanced Cancer Immunotherapy

Advanced Science, Год журнала: 2021, Номер 9(1)

Опубликована: Ноя. 19, 2021

Abstract The past decades have witnessed great progress in cancer immunotherapy, which has profoundly revolutionized oncology, whereas low patient response rates and potential immune‐related adverse events remain major clinical challenges. With the advantages of controlled delivery modular flexibility, nanomedicine offered opportunities to strengthen antitumor immune responses sensitize tumor immunotherapy. Furthermore, tumor‐microenvironment (TME)‐responsive been demonstrated achieve specific localized amplification tissue a safe effective manner, increasing immunotherapy reducing side effects simultaneously. Here, recent TME‐responsive for is summarized, responds signals TME, such as weak acidity, reductive environment, high‐level reactive oxygen species, hypoxia, overexpressed enzymes, adenosine triphosphate. Moreover, combine nanomedicine‐based therapy immunotherapeutic strategies overcome each step cancer‐immunity cycle enhance discussed. Finally, existing challenges further perspectives this rising field with hope improved development applications are

Язык: Английский

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Emerging photodynamic nanotherapeutics for inducing immunogenic cell death and potentiating cancer immunotherapy

Biomaterials, Год журнала: 2022, Номер 282, С. 121433 - 121433

Опубликована: Фев. 19, 2022

Язык: Английский

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Nanotechnology for Boosting Cancer Immunotherapy and Remodeling Tumor Microenvironment: The Horizons in Cancer Treatment

ACS Nano, Год журнала: 2021, Номер 15(8), С. 12567 - 12603

Опубликована: Авг. 2, 2021

Immunotherapy that harnesses the human immune system to fight cancer has received widespread attention and become a mainstream strategy for treatment. Cancer immunotherapy not only eliminates primary tumors but also treats metastasis recurrence, representing major advantage over traditional treatments. Recently with development of nanotechnology, there exists much work applying nanomaterials on basis their excellent physiochemical properties, such as efficient tissue-specific delivery function, huge specific surface area, controllable chemistry. Consequently, nanotechnology holds significant potential in improving efficacy immunotherapy. Nanotechnology-based mainly manifests its inhibitory effect via two different approaches: one is produce an effective anti-tumor response during tumorigenesis, other enhance tumor defense ability by modulating suppression mechanism microenvironment. With success immunotherapy, understanding interaction between smart nanomedicine provided vigorous vitality This review highlights application, progress, prospect process immunoediting discusses several engineering methods improve efficiency

Язык: Английский

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Which cell death modality wins the contest for photodynamic therapy of cancer?

Cell Death and Disease, Год журнала: 2022, Номер 13(5)

Опубликована: Май 13, 2022

Abstract Photodynamic therapy (PDT) was discovered more than 100 years ago. Since then, many protocols and agents for PDT have been proposed the treatment of several types cancer. Traditionally, cell death induced by categorized into three types: apoptosis, associated with autophagy, necrosis. However, discovery other regulated modalities in recent years, it has become clear that this is a rather simple understanding mechanisms action PDT. New observations revealed cancer cells exposed to can pass through various non-conventional pathways, such as paraptosis, parthanatos, mitotic catastrophe, pyroptosis, necroptosis, ferroptosis. Nowadays, immunogenic (ICD) one most promising ways eradicate tumor activation T-cell adaptive immune response induction long-term immunological memory. ICD be triggered anti-cancer methods, including In review, we critically discuss findings on Next, emphasize role contribution these PDT-induced modalities. Finally, obstacles propose areas research will help overcome challenges lead development highly effective based

Язык: Английский

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