Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(44)
Опубликована: Сен. 9, 2022
Abstract
The
use
of
temperature‐controlled
mechanochemistry
to
enable
the
mechanochemical
nickel‐catalyzed
Suzuki–Miyaura
coupling
is
herein
described.
Transitioning
from
a
capricious
room‐temperature
protocol,
through
heated,
PID‐controlled
programmable
jar
heater
manifold
was
required
deliver
an
efficient
method
for
aryl
sulfamates
(derived
ubiquitous
phenols)
and
boronic
acid
species.
Furthermore,
this
process
conducted
using
base‐metal
nickel
catalyst,
in
absence
bulk
solvent,
air/moisture
sensitive
reaction
set‐ups.
This
methodology
showcased
translation
large‐scale
twin‐screw
extrusion
enabling
200‐fold
scale
increase,
producing
decagram
quantities
C−C
coupled
material.
ChemSusChem,
Год журнала:
2021,
Номер
14(10), С. 2145 - 2162
Опубликована: Апрель 9, 2021
In
recent
years,
mechanochemistry
has
been
growing
into
a
widely
accepted
alternative
for
chemical
synthesis.
addition
to
their
efficiency
and
practicality,
mechanochemical
reactions
are
also
recognized
sustainability.
The
association
between
Green
Chemistry
often
originates
from
the
solvent-free
nature
of
most
protocols,
which
can
reduce
waste
production.
However,
satisfies
more
than
one
Principles
Chemistry.
this
Review
we
will
present
series
examples
that
clearly
illustrate
how
significantly
contribute
fulfillment
in
holistic
manner.
Advanced Synthesis & Catalysis,
Год журнала:
2021,
Номер
363(5), С. 1246 - 1271
Опубликована: Янв. 21, 2021
Abstract
Mechanochemical
reactions
by
milling,
grinding
or
other
types
of
mechanical
action
have
emerged
as
a
salient
green
approach
because
its
wide
applications
towards
academic
and
industrial
chemical
communities
in
sustainable
solvent‐free/solvent‐less
processes.
Liquid‐assisted
(LAG)
an
extension
traditional
solvent‐free
mechanochemical
techniques
which
small
amount
liquid
is
used
additive
to
enhance
and/or
control
reactivity,
has
been
fruitfully
applied
the
screening
inclusion
compounds,
cocrystals,
salts,
solvates,
polymorphs.
However,
utilization
this
important
technique
synthesis
pharmaceutically
biologically
relevant
targets
was
not
adequately
investigated.
This
review
article
summarizes
overview
latest
development
LAG
approaches
active
pharmaceutical
ingredients
(API)
drug‐like
fragments,
highlights
superiority
versus
conventional
syntheses.
magnified
image
Mechanochemical
transformations
have
made
chemists
enter
unknown
territories,
forcing
a
different
chemistry
perspective.
While
questioning
or
revisiting
familiar
concepts
belonging
to
solution
chemistry,
mechanochemistry
has
broken
new
ground,
especially
in
the
panorama
of
organic
synthesis.
Not
only
does
it
foster
"thinking
outside
box",
but
also
opened
reaction
paths,
allowing
overcome
weaknesses
traditional
exactly
where
use
well-established
solution-based
methodologies
rules
out
progress.
In
this
Review,
reader
is
introduced
an
intriguing
research
subject
not
yet
fully
explored
and
waiting
for
improved
understanding.
Indeed,
study
mainly
focused
on
that,
although
impossible
solution,
become
possible
under
mechanochemical
processing
conditions,
simultaneously
entailing
innovation
expanding
chemical
space.
Nature Communications,
Год журнала:
2021,
Номер
12(1)
Опубликована: Ноя. 18, 2021
Since
the
discovery
of
Grignard
reagents
in
1900,
nucleophilic
addition
magnesium-based
carbon
nucleophiles
to
various
electrophiles
has
become
one
most
powerful,
versatile,
and
well-established
methods
for
formation
carbon-carbon
bonds
organic
synthesis.
are
typically
prepared
via
reactions
between
halides
magnesium
metal
a
solvent.
However,
this
method
usually
requires
use
dry
solvents,
long
reaction
times,
strict
control
temperature,
inert-gas-line
techniques.
Despite
utility
reagents,
these
requirements
still
represent
major
drawbacks
from
both
an
environmental
economic
perspective,
often
cause
reproducibility
problems.
Here,
we
report
general
mechanochemical
synthesis
(Grignard
paste
form)
air
using
ball
milling
technique.
These
can
be
used
directly
one-pot
with
nickel-catalyzed
cross-coupling
under
solvent-free
conditions.
Chemistry - A European Journal,
Год журнала:
2021,
Номер
27(38), С. 9721 - 9726
Опубликована: Апрель 1, 2021
Abstract
Recent
research
endeavors
have
established
that
the
mechanochemical
activation
of
piezoelectric
materials
can
open
new
avenues
in
redox
chemistry.
Impact
forces,
such
as
those
imparted
by
a
ball
mill,
been
shown
to
transform
barium
titanate
(BaTiO
3
)
into
highly
polarized
state,
which
then
donate
an
electron
suitable
oxidant
and
receive
from
reductant,
mimicking
photoredox
catalytic
cycles.
Proof‐of‐concept
studies
elucidated
mechanoredox
chemistry
holds
great
potential
sustainable
efficient
radical‐based
synthesis.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(11), С. 4243 - 4260
Опубликована: Янв. 1, 2022
Reactive
extrusion
provides
a
scale-up
opportunity
to
turn
mechanochemical
process
from
ball-mill
into
continuous
flow.
This
tutorial
review
summarises
some
of
the
early
ground-breaking
work
in
this
area.
Chemical Communications,
Год журнала:
2022,
Номер
58(11), С. 1661 - 1671
Опубликована: Янв. 1, 2022
Direct
mechanocatalysis
(DM)
describes
solvent-free
catalytic
reactions
that
are
initiated
by
mechanical
forces
in
mechanochemical
reactors
such
as
ball
mills.
The
distinctive
feature
of
DM
is
the
milling
materials,
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(19), С. 6680 - 6714
Опубликована: Янв. 1, 2023
The
quantitative
assessment
of
the
greenness
mechanochemical
processes
for
green
metrics
were
calculated
is
herein
reported.
A
general
introduction
to
topic,
variables
influencing
reaction
outcome
and,
an
outlook
are
also
provided.
ACS Sustainable Chemistry & Engineering,
Год журнала:
2022,
Номер
10(4), С. 1430 - 1439
Опубликована: Янв. 20, 2022
The
scale-up
of
mechanochemical
methods
could
play
a
transformative
role
in
making
manufacturing
processes
the
pharmaceutical
industry
greener
by
eliminating
solvent
use
and
recovery.
Combined
with
energy-efficient
continuous
processing
that
consolidates
reaction
steps,
mechanochemistry's
environmental
economic
benefits
may
translate
across
product
supply
chains.
Here,
we
evaluate
numerous
sustainability
green
chemistry
metrics
for
producing
nitrofurantoin,
an
active
ingredient
(API),
via
twin-screw
extrusion
(TSE)
conventional
solvent-batch
synthesis
methods.
We
find
significant
reduction
all
TSE
including
energy,
climate
change,
human
ecological
health,
as
well
cost
due
to
reducing
excess
reactant
consumption
solvents
while
maintaining
high
selectivity.
In
addition,
replacing
direct
energy
source
drive
chemical
from
mostly
thermal
electrical
sources
does
not
increase
net
life
cycle
consumed
produce
functionally
equivalent
API.
conclude
holds
multiple
APIs
potentially
other
products.
