Journal of Controlled Release, Год журнала: 2023, Номер 355, С. 273 - 291
Опубликована: Фев. 9, 2023
Язык: Английский
Nature Cardiovascular Research, Год журнала: 2023, Номер 2(4), С. 351 - 367
Опубликована: Апрель 3, 2023
The leading cause of death in the world, cardiovascular disease (CVD), remains a formidable condition for researchers, clinicians and patients alike. CVD comprises broad collection diseases spanning heart, vasculature blood that runs through interconnects them. Limitations therapeutic diagnostic landscapes have generated excitement advances nanomedicine, field focused on improving patient outcomes transformative therapies, imaging agents ex vivo diagnostics. nanomedicines are fundamentally shaped by their intended clinical application, including (1) cardiac or heart-related biomaterials, which can be functionally (for example, mechanically, immunologically, electrically) improved incorporating nanomaterials; (2) vasculature, involving systemically injected nanotherapeutics nanodiagnostics, nano-enabled biomaterials tissue-nanoengineered solutions; (3) sensitivity and/or specificity devices samples. While immunotherapy has developed into key pillar oncology past dozen years, immunoimaging recently emergent likely to factor substantially management coming decade. nanomaterials CVD-related trials many promising preclinical strategies indicate nanomedicine is cusp greatly impacting with CVD. Here we review these recent advances, highlighting opportunities rapidly emerging nanomedicine.
Язык: Английский
Процитировано
76
Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(33)
Опубликована: Апрель 21, 2023
Nanozymes, nanomaterials with enzyme-mimicking activity, have attracted tremendous interest in recent years owing to their ability replace natural enzymes various biomedical applications, such as biosensing, therapeutics, drug delivery, and bioimaging. In particular, the nanozymes capable of regulating cellular redox status by mimicking antioxidant mammalian cells are great therapeutic significance oxidative-stress-mediated disorders. As distinction physiological oxidative stress (oxidative eustress) pathological distress) occurs at a fine borderline, it is challenge design that can differentially sense two extremes cells, tissues organs mediate appropriate chemical reactions. this Review, we summarize advances development redox-active applications. We primarily highlight prooxidant disease model systems, cancer, neurodegeneration, cardiovascular diseases. The future perspectives emerging area research challenges associated applications described.
Язык: Английский
Процитировано
63
Advanced Materials, Год журнала: 2023, Номер 36(10)
Опубликована: Апрель 5, 2023
Metabolism is the sum of enzyme-dependent chemical reactions, which produces energy in catabolic process and synthesizes biomass anabolic process, exhibiting high similarity mammalian cell, microbial plant cell. Consequently, loss or gain metabolic enzyme activity greatly affects cellular metabolism. Nanozymes, as emerging mimics with diverse functions adjustable catalytic activities, have shown attractive potential for regulation. Although basic tasks are highly similar cells from different species, concrete pathway varies intracellular structure species. Here, metabolism living organisms described similarities differences pathways among mammalian, microbial, regulation mechanism discussed. The recent progress on mainly including nutrient uptake utilization, production, accompanied redox reactions by kinds oxidoreductases their applications field disease therapy, antimicrobial sustainable agriculture systematically reviewed. Furthermore, prospects challenges nanozymes regulating cell also discussed, broaden application scenarios.
Язык: Английский
Процитировано
51
ACS Nano, Год журнала: 2024, Номер unknown
Опубликована: Янв. 24, 2024
Overproduction of reactive oxygen species by damaged mitochondria after ischemia is a key factor in the subsequent cascade damage. Delivery therapeutic agents to neurons brain potentially promising targeted strategy for treatment ischemic stroke. In this study, we developed ceria nanoenzymes synergistic drug-carrying nanosystem targeting address multiple factors Each component works individually as well synergistically, resulting comprehensive therapy. Alleviation oxidative stress and modulation mitochondrial microenvironment into favorable state tolerance are combined restore bridging injuries. This work also revealed detailed mechanisms which proposed nanodelivery system protects brain, represents paradigm shift stroke treatment.
Язык: Английский
Процитировано
50
Acta Biomaterialia, Год журнала: 2023, Номер 168, С. 580 - 592
Опубликована: Июль 13, 2023
Язык: Английский
Процитировано
45
Nature Protocols, Год журнала: 2024, Номер 19(12), С. 3470 - 3488
Опубликована: Авг. 15, 2024
Язык: Английский
Процитировано
45
Journal of Hematology & Oncology, Год журнала: 2024, Номер 17(1)
Опубликована: Апрель 23, 2024
Abstract Tumor is a local tissue hyperplasia resulted from cancerous transformation of normal cells under the action various physical, chemical and biological factors. The exploration tumorigenesis mechanism crucial for early prevention treatment tumors. Epigenetic modification common important in cells, including DNA methylation, histone modification, non-coding RNA m6A modification. mode cell death programmed by death-related genes; however, recent researches have revealed some new modes death, pyroptosis, ferroptosis, cuproptosis disulfidptosis. regulation deaths mainly involved key proteins affects up-regulating or down-regulating expression levels proteins. This study aims to investigate epigenetic modifications regulating disulfidptosis tumor explore possible triggering factors development microscopic point view, provide potential targets therapy perspective antitumor drugs combination therapies.
Язык: Английский
Процитировано
37
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Май 15, 2024
With increasing proportion of the elderly in population, age-related diseases (ARD) lead to a considerable healthcare burden society. Prevention and treatment ARD can decrease negative impact aging disease. The rate is closely associated with production high levels reactive oxygen species (ROS). ROS-mediated oxidative stress triggers aging-related changes through lipid peroxidation, protein oxidation, DNA oxidation. Antioxidants control autoxidation by scavenging free radicals or inhibiting their formation, thereby reducing stress. Benefiting from significant advances nanotechnology, large number nanomaterials ROS-scavenging capabilities have been developed. be divided into two categories: as carriers for delivering drugs, themselves activity. This study summarizes current prevention ARD, highlights potential mechanisms used discusses challenges prospects applications.
Язык: Английский
Процитировано
26
Coordination Chemistry Reviews, Год журнала: 2024, Номер 508, С. 215761 - 215761
Опубликована: Март 12, 2024
Язык: Английский
Процитировано
25
Theranostics, Год журнала: 2024, Номер 14(9), С. 3739 - 3759
Опубликована: Янв. 1, 2024
The repair of osteoporotic bone defects remains challenging due to excessive reactive oxygen species (ROS), persistent inflammation, and an imbalance between osteogenesis osteoclastogenesis.
Язык: Английский
Процитировано
22