Advanced technology in neuroscience .,
Год журнала:
2024,
Номер
1(2), С. 244 - 260
Опубликована: Ноя. 27, 2024
Nerve
injury
often
leads
to
degeneration
or
necrosis
of
damaged
nerve
cells,
which
can
result
in
regeneration
disorders
during
the
repair
process.
Promoting
is
a
critical
challenge
treatment
nervous
system
diseases.
With
rapid
advancements
related
research,
chemical
materials
have
shown
significant
promise
facilitating
because
their
excellent
biocompatibility
and
degradability.
The
use
tissue-engineered
material
scaffolds
provide
physical
channels
for
regeneration.
These
create
optimal
conditions
cell
growth
migration
effectively
regulate
physiological
processes
repair.
Therefore,
wide
range
applications
field
This
review
highlights
technological
tools
available
involving
materials.
(1)
Conductive
hydrogels:
Novel
conductive
hydrogels
been
developed
by
integrating
such
as
graphene,
carbon
nanotubes,
polypyrrole,
promote
functional
recovery
cells
through
electrical
stimulation.
(2)
Three-dimensional
printing:
printing
technology
contributes
precise
control
shape,
porosity
degradation
rate
scaffolds,
providing
customized
microenvironment
(3)
Nanomaterials:
unique
physicochemical
properties
nanoparticles
nanofibers
give
them
great
potential
penetrate
blood‒brain
barrier,
guide
targeted
drug
delivery.
(4)
Local
release
bioactive
molecules:
Through
design
materials,
controlled
molecules
factor,
brain-derived
neurotrophic
factor
fibroblast
has
realized,
promotes
(5)
Photothermal
photoacoustic
stimulation:
combination
photothermal
technologies
led
development
capable
responding
photostimulation,
new
avenues
noninvasive
neurostimulation.
engineering
are
highly
effective
promoting
significantly
improve
efficiency
quality
In
clinical
practice,
these
techniques
expected
more
strategies
patients
with
injuries,
improving
function
life.
also
discusses
detail
different
biocompatibility,
mechanical
strength,
degradability,
A
variety
neural
tissue
scaffold
techniques,
including
provision
support,
molecules,
direct
interaction
cells.
Although
show
potential,
several
challenges,
long-term
stability,
individual
variation
response,
large-scale
production,
still
need
be
addressed
before
they
translated
into
applications.
addition,
comprehensive
assessment
safety
efficacy
focus
future
research.
Future
research
will
on
optimizing
conducting
trials
validate
techniques.
Journal of Biomedical Materials Research Part A,
Год журнала:
2025,
Номер
113(2)
Опубликована: Фев. 1, 2025
The
combination
of
nerve
guide
conduits
(NGCs)
and
electrical
stimulation
(ES)
is
an
effective
treatment
for
peripheral
injury
(PNI).
Flexible
conductive
materials
with
mechanical
properties
similar
to
those
biological
tissues
have
been
shown
better
long-term
biointegration
functionality
than
rigid
materials.
In
this
study,
liquid
metal
(LM)-based
polycaprolactone/gelatin/polypyrrole/LM
(PCL/Gel/PPy/LM,
PGPL)
NGC
was
combined
exogenous
ES
repair
PNI.
PGPL
membranes
had
good
hydrophilicity,
degradability,
properties,
its
conductivity
reached
0.66
±
0.02
S/m.
vitro
studies
showed
that
the
(2
Hz,
100
mV/cm,
30
min/d)
could
significantly
increase
expression
neuromarkers
a
pro-neural
differentiation
effect.
vivo
demonstrated
NGCs
in
200
mV/mm,
effectively
promote
morphological
reconstruction
functional
recovery
sciatic
rats.
At
3
months
post-surgery,
restored
conduction
velocity
73.85%
5.45%
normal
value.
LM-based
prepared
study
long
defects,
which
may
further
expand
application
LM
field
tissue
engineering.
Abstract
Diabetic
wounds
present
a
significant
challenge
in
clinical
treatment
and
are
characterized
by
chronic
inflammation,
oxidative
stress,
impaired
angiogenesis,
peripheral
neuropathy,
heightened
risk
of
infection
during
the
healing
process.
By
creating
small
channels
surface
skin,
microneedle
technology
offers
minimally
invasive
efficient
approach
for
drug
delivery
treatment.
This
article
begins
outlining
biological
foundation
normal
skin
wound
unique
pathophysiological
mechanisms
diabetic
wounds.
It
then
delves
into
various
types,
materials,
preparation
processes
microneedles.
The
focus
is
on
application
multifunctional
microneedles
treatment,
highlighting
their
antibacterial,
anti-inflammatory,
immunomodulatory,
antioxidant,
angiogenic
neural
repair
properties.
These
demonstrate
synergistic
therapeutic
effects
directly
influencing
microenvironment,
ultimately
accelerating
advancement
not
only
holds
promise
enhancing
outcomes
but
also
new
strategies
addressing
other
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101503 - 101503
Опубликована: Фев. 6, 2025
Peripheral
nerve
injuries
are
a
prevalent
global
issue
that
has
garnered
great
concern.
Although
autografts
remain
the
preferred
clinical
approach
to
repair,
their
efficacy
is
hampered
by
factors
like
donor
scarcity.
The
emergence
of
guidance
conduits
as
novel
tissue
engineering
tools
offers
promising
alternative
strategy.
This
review
aims
interpret
and
commercialization
from
both
laboratory
perspectives.
To
enhance
comprehension
situations,
this
article
provides
comprehensive
analysis
approved
United
States
Food
Drug
Administration.
It
proposes
initial
six
months
post-transplantation
critical
window
period
for
evaluating
efficacy.
Additionally,
study
conducts
systematic
discussion
on
research
progress
conduits,
focusing
biomaterials
add-on
strategies
pivotal
regeneration,
supported
literature
analysis.
conduit
materials
prospective
optimal
thoroughly
discussed.
strategies,
together
with
distinct
obstacles
potentials
deeply
analyzed.
Based
above
evaluations,
development
path
manufacturing
strategy
envisioned.
conclusion
promoting
summarized
follows:
1)
optimization
fundamental
means;
2)
phased
application
additional
emphasized
direction;
3)
additive
techniques
necessary
tools.
As
result,
findings
provide
academic
practitioners
valuable
insights
may
facilitate
future
endeavors
conduits.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
Tissue
engineering
aims
to
repair
damaged
tissues
with
physiological
functions
recovery.
Although
several
therapeutic
strategies
are
there
for
tissue
regeneration,
the
functional
recovery
of
regenerated
still
poses
significant
challenges
due
lack
concerns
innervation.
Design
rationale
multifunctional
biomaterials
both
tissue-induction
and
neural
induction
activities
shows
great
potential
regeneration.
Recently,
research
application
inorganic
attracts
increasing
attention
in
innervated
multi-tissue
such
as
central
nerves,
bone,
skin,
because
its
superior
tunable
chemical
composition,
topographical
structures,
physiochemical
properties.
More
importantly,
easily
combined
other
organic
materials,
biological
factors,
external
stimuli
enhance
their
effects.
This
review
presents
a
comprehensive
overview
recent
advancements
It
begins
introducing
classification
properties
typical
design
inorganic-based
material
composites.
Then,
progresses
regenerating
various
nerves
nerve-innervated
systematically
reviewed.
Finally,
existing
future
perspectives
proposed.
may
pave
way
direction
offers
new
strategy
regeneration
combination
Emerging
piezoelectric
metamaterials
hold
immense
promise
for
biomedical
applications
by
merging
the
intrinsic
electrical
properties
of
piezoelectricity
with
precise
architecture
metamaterials.
This
review
provides
a
comprehensive
overview
various
materials-
such
as
molecular
crystals,
ceramics,
and
polymers-known
their
exceptional
performance
biocompatibility.
We
explore
advanced
engineering
approaches,
including
design,
supramolecular
packing,
3D
assembly,
which
enable
customization
targeted
applications.
Particular
attention
is
given
to
pivotal
role
metamaterial
structuring
in
development
0D
spheres,
1D
fibers
tubes,
2D
films,
scaffolds.
Key
applications,
tissue
engineering,
drug
delivery,
wound
healing,
biosensing,
are
discussed
through
illustrative
examples.
Finally,
article
addresses
critical
challenges
future
directions,
aiming
drive
further
innovations
biomaterials
next-generation
healthcare
technologies.
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 8, 2024
Electrical
stimulation
has
been
hotpot
research
and
provoked
extensive
interest
in
a
broad
application
such
as
wound
closure,
tissue
injury
repair,
nerve
engineering.
In
particular,
immense
efforts
have
dedicated
to
developing
electrical
microneedles,
which
demonstrate
unique
features
terms
of
controllable
drug
release,
real-time
monitoring,
therapy,
thus
greatly
accelerating
the
process
healing.
Here,
review
state-of-art
concerning
microneedles
applied
for
treatment
is
presented.
After
comprehensive
analysis
mechanisms
on
healing,
derived
three
types
are
clarified
summarized.
Further,
their
applications
healing
highlighted.
Finally,
current
perspectives
directions
development
future
improving
addressed.
The
self-assembly
of
giant
amphiphilic
molecules
with
diverse
topological
structures
has
been
widely
investigated
in
bulk,
solution,
and
interfacial
environments
because
it
can
lead
to
interesting
geometric
patterns.
However,
many
or
their
self-assembling
units
are
built
by
covalent
bonds,
which
may
limit
the
movement
molecular
blocks,
affecting
process
microstructure.
In
contrast,
noncovalent
interactions
nanomorphologies
nanostructures.
this
study,
we
(BPOSS&POM)
forming
electrostatic
between
hydrophobic
isobutyl
polyhedral
oligomeric
silsesquioxanes
(BPOSSs)
hydrophilic
polyoxometalates
(POMs)
investigate
behavior
water/acetone,
water/THF,
hexane/acetone
cosolvents.
By
controlling
solvent
parameters,
BPOSS&POM
self-assembled
into
nanosheet,
nanobelt,
nanosphere,
nanocrumb
structures.
morphology
detailed
nanostructure
different
self-assemblies
were
revealed
performing
transmission
electron
microscopy
(TEM),
scanning
(SEM),
small-angle
X-ray
scattering
(SAXS)
measurements.
TEM
SAXS
results
indicated
that
microphase
exhibited
a
lamellar
structure
an
interlayer
distance
about
3
nm.
was
alternatively
organized
layers
BPOSS
POM
according
size
dimension.
polarity
solvents
substantially
affected
nanoassemblies
but
not
aggregation
POM.
This
research
offers
insights
preparation
nanomaterials
micromorphologies
simply
adjusting
solution
components.
