Advanced Composites and Hybrid Materials, Год журнала: 2025, Номер 8(3)
Опубликована: Май 9, 2025
Язык: Английский
Chemical Reviews, Год журнала: 2025, Номер unknown
Опубликована: Янв. 27, 2025
Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.
Язык: Английский
Процитировано
5
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Фев. 20, 2025
The advent of nanozymes has revolutionized approaches to cancer diagnosis and therapy, introducing innovative strategies that address the limitations conventional treatments. Nanozyme nanostructures with enzyme-mimicking catalytic abilities exhibit exceptional stability, biocompatibility, customizable functions, positioning them as promising tools for theranostics. By emulating natural enzyme reactions, can selectively target eradicate cells, minimizing harm adjacent healthy tissues. Nanozymes also be functionalized specific targeting ligands, allowing precise delivery regulated release therapeutic agents, improving treatment effectiveness reducing adverse effects. However, issues such selectivity, regulatory compliance remain critical challenges clinical application nanozymes. This review provides an overview nanozymes, highlighting their unique properties, various classifications, activities, diverse applications in strategic oncological deployment could profoundly impact future advancements personalized medicine, recent progress prospective directions enzyme-mimetic treatment. summarizes
Язык: Английский
Процитировано
3
Chemical Engineering Journal, Год журнала: 2025, Номер 505, С. 159676 - 159676
Опубликована: Янв. 17, 2025
Язык: Английский
Процитировано
2
Accounts of Materials Research, Год журнала: 2025, Номер unknown
Опубликована: Янв. 22, 2025
Язык: Английский
Процитировано
2
Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 250, С. 114573 - 114573
Опубликована: Фев. 18, 2025
Язык: Английский
Процитировано
1
Acta Biomaterialia, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
6
ACS Nano, Год журнала: 2024, Номер unknown
Опубликована: Дек. 4, 2024
Triple-negative breast cancer (TNBC) is the most aggressive and lethal subtype of among women. Chemotherapy acts as standard regimen for TNBC treatment but suffers from limited drug accumulation in tumor regions undesired side effects. Herein, we developed a synergistic strategy by combining red blood cell (RBC) membrane-liposome hybrid nanovesicle with short-term fasting (STF) improved chemotherapy TNBC. The biomimetic nanovesicles exhibited reduced phagocytosis macrophages while displaying significant increase uptake through caveolae/raft-mediated endocytosis under nutrient-deprivation conditions. Importantly, drug-loaded STF synergistically increased cytotoxicity cells inhibiting their cycles aerobic glycolysis well amplifying reactive oxygen species (ROS) autophagosomes generation. In STF-treated mice, greatly antitumor efficacy at lower dosage inhibited metastasis Overall, demonstrated that synergizing therapy serve promising therapeutic enhanced malignant
Язык: Английский
Процитировано
6
Materials Today Bio, Год журнала: 2024, Номер 29, С. 101255 - 101255
Опубликована: Сен. 17, 2024
Язык: Английский
Процитировано
5
Biomaterials, Год журнала: 2024, Номер 314, С. 122869 - 122869
Опубликована: Окт. 10, 2024
Язык: Английский
Процитировано
5
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер unknown
Опубликована: Окт. 25, 2024
Hepatocellular carcinoma (HCC) is a highly malignant tumor that resistant to chemotherapy and immunotherapy. Icaritin (ICT), traditional Chinese medicine, has been reported as an immunoregulatory agent for treating advanced unresectable HCC. ICT induces mitophagy cause immunogenic cell death (ICD); however, the poor bioavailability of limits its therapeutic efficacy clinical use. Therefore, this study aimed assess effect using poly(2-(
Язык: Английский
Процитировано
4