The Chemical Record,
Год журнала:
2024,
Номер
24(12)
Опубликована: Ноя. 11, 2024
Abstract
This
review
provides
a
comprehensive
examination
of
the
applications
seminal
coupling
principle
introduced
by
Siegfried
Dähne
and
Dieter
Leupold
in
1966.
Their
heuristic
groundbreaking
work
proposed
that
combining
multiple
polymethine
subunits
within
single
chromophore
enables
orbital
coupling,
consequently
narrowing
HOMO–LUMO
gap,
yielding
redshifted
optical
properties.
These
outcomes
are
particularly
valuable
for
developing
organic
dyes
tailored
visible‐to‐near‐infrared
applications.
Despite
their
potential,
coupled
polymethines
remain
relatively
underexplored,
with
most
reported
instances
being
serendipitous
discoveries
over
last
six
decades.
In
light
this,
our
compiles
discusses
structures,
covering
synthetic,
spectroscopic,
theoretical
applicative
aspects,
offering
insights
into
structure‐property
relationships
this
unique
class
perspectives
future
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
63(11)
Опубликована: Дек. 12, 2023
Abstract
Organic
fluorophores
are
indispensable
tools
in
cells,
tissue
and
vivo
imaging,
have
enabled
much
progress
the
wide
range
of
biological
biomedical
fields.
However,
many
available
dyes
suffer
from
insufficient
performances,
such
as
short
absorption
emission
wavelength,
low
brightness,
poor
stability,
small
Stokes
shift,
unsuitable
permeability,
restricting
their
application
advanced
imaging
technology
complex
imaging.
Over
past
two
decades,
efforts
been
made
to
improve
these
performances
fluorophores.
Starting
with
luminescence
principle
fluorophores,
this
review
clarifies
mechanisms
performance
for
traditional
a
certain
extent,
systematically
summarizes
modified
approaches
optimizing
properties,
highlights
typical
applications
improved
sensing,
indicates
existing
problems
challenges
area.
This
not
only
proves
significance
improving
but
also
provide
theoretical
guidance
development
high‐performance
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(16)
Опубликована: Март 5, 2024
Fluorescence
imaging
in
the
second
near-infrared
window
(NIR-II)
is
burgeoning
because
of
its
higher
fidelity
monitoring
physiological
and
pathological
processes
than
clinical
visible/the
fluorescence
imaging.
Notably,
heavily
dependent
on
agents.
So
far,
indocyanine
green,
one
polymethine
dyes,
with
good
biocompatibility
renal
clearance
only
dye
approved
by
Food
Drug
Administration,
but
it
shows
relatively
low
NIR-II
brightness.
Importantly,
tremendous
efforts
are
devoted
to
synthesizing
dyes
for
preclinically
clinically.
They
have
shown
feasibility
customization
structure
properties
fulfill
various
needs
therapy.
Herein,
a
timely
update
special
focus
molecular
design
strategies
fluorescent,
photoacoustic,
multimodal
imaging,
offered.
Furthermore,
progress
sensing
biomarkers
even
reporting
drug
release
illustrated.
Moreover,
imaging-guided
therapies
summarized
regarding
chemo-,
photothermal,
photodynamic,
approaches.
In
addition,
artificial
intelligence
pointed
out
potential
expedite
development.
This
comprehensive
review
will
inspire
interest
among
wide
audience
offer
handbook
people
an
dyes.
ACS Nano,
Год журнала:
2023,
Номер
17(17), С. 17468 - 17475
Опубликована: Авг. 21, 2023
Biological
channels
can
rapidly
and
continuously
modulate
ion
transport
behaviors
in
response
to
external
stimuli,
which
play
essential
roles
manipulating
physiological
pathological
processes
cells.
Here,
mimic
the
biological
channels,
a
bionic
nanochannel
is
developed
by
synergizing
cationic
silicon-substituted
rhodamine
(SiRh)
with
glass
nanopipette
for
transmembrane
single-cell
quantification.
Taking
fast
reversible
nucleophilic
addition
reaction
between
glutathione
(GSH)
SiRh,
shows
GSH,
its
inner-surface
charges
changing
positive
negative
charges,
leading
distinct
switch
ionic
current
rectification
(ICR).
With
nanochannel,
spatiotemporal-resolved
operation
performed
quantify
endogenous
GSH
single
cell,
allowing
monitoring
of
intracellular
fluctuation
tumor
cells
upon
photodynamic
therapy
ferroptosis.
Our
results
demonstrate
that
it
feasible
tool
situ
quantification
cells,
may
be
adapted
addressing
other
biomolecules
usage
stimuli-responsive
probes.
Molecular
imaging
is
a
non-invasive
method
that
widely
used
for
visualization
and
detection
of
biological
events
at
cellular
or
molecular
levels.
Stimuli-responsive
linkers
can
be
selectively
cleaved
by
specific
biomarkers
desired
sites
to
release
activate
agents
are
appealing
tools
improve
the
specificity,
sensitivity,
efficacy
imaging.
This
review
summarizes
recent
advances
stimuli-responsive
their
application
in
imaging,
highlighting
potential
these
design
activatable
probes.
It
hoped
this
could
inspire
more
research
interests
development
responsive
associated
applications.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(19), С. 13163 - 13175
Опубликована: Май 3, 2024
A
pretargeted
strategy
that
decouples
targeting
vectors
from
radionuclides
has
shown
promise
for
nuclear
imaging
and/or
therapy
in
vivo.
However,
the
current
approach
relies
on
use
of
antibodies
or
nanoparticles
as
vectors,
which
may
be
compromised
by
poor
tissue
penetration
and
limited
accumulation
tumor
tissues.
Herein,
we
present
an
orthogonal
dual-pretargeted
combining
stimuli-triggered
situ
self-assembly
with
fast
inverse
electron
demand
Diels-Alder
(IEDDA)
reaction
strong
biotin-streptavidin
(SA)
interaction
near-infrared
fluorescence
(NIR
FL)
magnetic
resonance
(MR)
tumors.
This
uses
a
small-molecule
probe
(P-Cy-TCO&Bio)
containing
both
biotin
trans-cyclooctene
(TCO)
tumor-targeting
vector.
P-Cy-TCO&Bio
can
efficiently
penetrate
subcutaneous
HeLa
tumors
through
biotin-assisted
targeted
delivery
undergo
to
form
biotinylated
TCO-bearing
(Cy-TCO&Bio
NPs)
cell
membranes.
Cy-TCO&Bio
NPs
exhibited
"off-on"
NIR
FL
retained
tumors,
offering
high
density
TCO
groups
concurrent
capture
Gd-chelate-labeled
tetrazine
(Tz-Gd)
IR780-labeled
SA
(SA-780)
via
IEDDA
SA-biotin
interaction.
Moreover,
offered
multiple-valent
binding
modes
toward
SA,
additionally
regulated
cross-linking
Cy-Gd&Bio
into
microparticles
(Cy-Gd&Bio/SA
MPs).
process
could
significantly
(1)
increase
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 12, 2024
Abstract
The
lanthanide
complex,
characterized
by
narrow
emission
bands,
large
Stokes
shifts,
long
luminescence
lifetime,
robust
resistance
to
photobleaching,
and
magnetic
properties,
affords
significant
promise
for
molecular
imaging
biosensing
applications.
While
most
complexes
emitting
visible
light
are
extensively
studied
cellular‐level
detection
bioimaging,
near‐infrared‐emitted
(700–1700
nm)
compounds
exhibit
more
favorable
properties
bioimaging
biosensing,
ascribed
from
deeper
penetration
reduced
bleaching
effects.
Besides,
the
complex
with
higher
resonance
signals
can
enhance
image
resolution
sensitivity,
offering
precise
analysis.
However,
widespread
use
of
high‐efficiency
is
currently
impeded
lack
design
approaches
improving
sensitization
chromophores
extended
excitation
wavelengths.
In
this
review,
some
fundamental
theories
strategies
summarized
imaging,
lifetime‐engineered
dual‐modal
now
highlight
a
selection
review
addresses
existing
gap
in
literature
proposing
feasible
fluorescent
properties.
Concurrently,
future
challenges
opportunities
field
probes
discussed.
Angewandte Chemie,
Год журнала:
2023,
Номер
136(11)
Опубликована: Дек. 12, 2023
Abstract
Organic
fluorophores
are
indispensable
tools
in
cells,
tissue
and
vivo
imaging,
have
enabled
much
progress
the
wide
range
of
biological
biomedical
fields.
However,
many
available
dyes
suffer
from
insufficient
performances,
such
as
short
absorption
emission
wavelength,
low
brightness,
poor
stability,
small
Stokes
shift,
unsuitable
permeability,
restricting
their
application
advanced
imaging
technology
complex
imaging.
Over
past
two
decades,
efforts
been
made
to
improve
these
performances
fluorophores.
Starting
with
luminescence
principle
fluorophores,
this
review
clarifies
mechanisms
performance
for
traditional
a
certain
extent,
systematically
summarizes
modified
approaches
optimizing
properties,
highlights
typical
applications
improved
sensing,
indicates
existing
problems
challenges
area.
This
not
only
proves
significance
improving
but
also
provide
theoretical
guidance
development
high‐performance
