Nano Letters,
Год журнала:
2023,
Номер
23(10), С. 4216 - 4225
Опубликована: Май 8, 2023
Adjuvant
whole-breast
radiotherapy
is
essential
for
breast
cancer
patients
who
adopted
breast-conserving
surgery
(BCS)
to
reduce
the
risk
of
local
recurrences,
which
however
suffer
from
large-area
and
highly
destructive
ionizing
radiation-induced
adverse
events.
To
tackle
this
issue,
an
afterglow/photothermal
bifunctional
polymeric
nanoparticle
(APPN)
developed
that
utilizes
nonionizing
light
precise
afterglow
imaging-guided
post-BCS
adjuvant
second
near-infrared
(NIR-II)
photothermal
therapy.
APPN
consists
a
tumor
cell
targeting
agent,
doped
with
NIR
dye
as
initiator
NIR-II
light-absorbing
semiconducting
polymer
transducer.
Such
design
realizes
ablation
minimal
residual
foci
after
BCS,
thus
achieving
complete
inhibition
recurrences.
Moreover,
enables
early
diagnosis
treatment
recurrence
BCS.
This
study
provides
modality
precision
therapy
theranostic.
ACS Nano,
Год журнала:
2023,
Номер
17(15), С. 14347 - 14405
Опубликована: Июль 24, 2023
Light
has
profoundly
impacted
modern
medicine
and
healthcare,
with
numerous
luminescent
agents
imaging
techniques
currently
being
used
to
assess
health
treat
diseases.
As
an
emerging
concept
in
luminescence,
aggregation-induced
emission
(AIE)
shown
great
potential
biological
applications
due
its
advantages
terms
of
brightness,
biocompatibility,
photostability,
positive
correlation
concentration.
This
review
provides
a
comprehensive
summary
AIE
luminogens
applied
structure
dynamic
physiological
processes,
disease
diagnosis
treatment,
detection
monitoring
specific
analytes,
followed
by
representative
works.
Discussions
on
critical
issues
perspectives
future
directions
are
also
included.
aims
stimulate
the
interest
researchers
from
different
fields,
including
chemistry,
biology,
materials
science,
medicine,
etc.,
thus
promoting
development
fields
life
health.
Chemical Reviews,
Год журнала:
2024,
Номер
124(11), С. 7106 - 7164
Опубликована: Май 17, 2024
The
identification
and
detection
of
disease-related
biomarkers
is
essential
for
early
clinical
diagnosis,
evaluating
disease
progression,
the
development
therapeutics.
Possessing
advantages
high
sensitivity
selectivity,
fluorescent
probes
have
become
effective
tools
monitoring
active
molecules
at
cellular
level
in
vivo.
In
this
review,
we
describe
current
designed
quantification
key
bioactive
associated
with
common
diseases,
such
as
organ
damage,
inflammation,
cancers,
cardiovascular
brain
disorders.
We
emphasize
strategies
behind
design
capable
biomarker
diagnosis
cover
some
aspects
combined
diagnostic/therapeutic
based
on
regulating
molecules.
This
review
concludes
a
discussion
challenges
outlook
probes,
highlighting
future
avenues
research
that
should
enable
these
to
achieve
accurate
biomedical
applications.
Chemical Reviews,
Год журнала:
2023,
Номер
124(2), С. 554 - 628
Опубликована: Ноя. 22, 2023
In
vivo
imaging
technologies
have
emerged
as
a
powerful
tool
for
both
fundamental
research
and
clinical
practice.
particular,
luminescence
in
the
tissue-transparent
near-infrared
(NIR,
700–1700
nm)
region
offers
tremendous
potential
visualizing
biological
architectures
pathophysiological
events
living
subjects
with
deep
tissue
penetration
high
contrast
owing
to
reduced
light–tissue
interactions
of
absorption,
scattering,
autofluorescence.
The
distinctive
quantum
effects
nanocrystals
been
harnessed
achieve
exceptional
photophysical
properties,
establishing
them
promising
category
luminescent
probes.
this
comprehensive
review,
between
light
tissues,
well
advantages
NIR
imaging,
are
initially
elaborated.
Subsequently,
we
focus
on
achieving
improved
by
optimizing
performance
nanocrystal
fluorophores.
ingenious
design
strategies
probes
discussed,
along
their
respective
biomedical
applications
versatile
modalities.
Finally,
thought-provoking
reflections
challenges
prospects
future
translation
nanocrystal-based
wisely
provided.
Molecular Biomedicine,
Год журнала:
2023,
Номер
4(1)
Опубликована: Окт. 16, 2023
Abstract
Ferroptosis,
a
regulated
form
of
cellular
death
characterized
by
the
iron-mediated
accumulation
lipid
peroxides,
provides
novel
avenue
for
delving
into
intersection
metabolism,
oxidative
stress,
and
disease
pathology.
We
have
witnessed
mounting
fascination
with
ferroptosis,
attributed
to
its
pivotal
roles
across
diverse
physiological
pathological
conditions
including
developmental
processes,
metabolic
dynamics,
oncogenic
pathways,
neurodegenerative
cascades,
traumatic
tissue
injuries.
By
unraveling
intricate
underpinnings
molecular
machinery,
contributors,
signaling
conduits,
regulatory
networks
governing
researchers
aim
bridge
gap
between
intricacies
this
unique
mode
multifaceted
implications
health
disease.
In
light
rapidly
advancing
landscape
ferroptosis
research,
we
present
comprehensive
review
aiming
at
extensive
in
origins
progress
human
diseases.
This
concludes
careful
analysis
potential
treatment
approaches
carefully
designed
either
inhibit
or
promote
ferroptosis.
Additionally,
succinctly
summarized
therapeutic
targets
compounds
that
hold
promise
targeting
within
various
facet
underscores
burgeoning
possibilities
manipulating
as
strategy.
summary,
enriched
insights
both
investigators
practitioners,
while
fostering
an
elevated
comprehension
latent
translational
utilities.
revealing
basic
processes
investigating
possibilities,
crucial
resource
scientists
medical
aiding
deep
understanding
effects
situations.
Analytical Chemistry,
Год журнала:
2023,
Номер
95(13), С. 5780 - 5787
Опубликована: Март 20, 2023
Intracellular
peroxynitrite
anions
(ONOO-)
and
microenvironments
(such
as
viscosity
polarity)
play
an
important
role
in
maintaining
redox
homeostasis,
regulating
diffusion,
transportation,
signal
transduction
living
cells.
The
abnormality
of
these
factors
is
often
closely
related
to
various
physiological/pathological
processes.
However,
owing
the
lack
suitable
probes,
simultaneous
visualization
ONOO-,
viscosity,
polarity
ferroptosis
cancer
models
has
not
been
achieved.
To
meet
urgent
needs,
we
presented
a
multifunctional
near-infrared
(NIR)
fluorescent
probe,
named
MQA-P,
for
simultaneously
detecting
within
mitochondria.
probe
exhibited
remarkable
turn-on
response
ONOO-
with
far-red
emission
about
645
nm
was
highly
sensitive
viscosity/polarity
NIR
channel
λem
>
704
nm.
Facilitated
by
first
time,
revealed
that
erastin-induced
accompanied
significant
upregulation
increase
(or
decrease
at
same
time.
Moreover,
concurrent
use
diagnosis
successfully
achieved
only
cell/tissue
levels
but
also
tumor
mice
models.
Compared
one
factor,
this
detection
multimarkers
provides
more
reliable
method/tool
tracking
ferroptosis-related
pathological
processes
diagnosis,
holding
great
potential
preclinical
research,
medical
imaging-guided
surgery.
Journal of the American Chemical Society,
Год журнала:
2023,
Номер
145(36), С. 19662 - 19675
Опубликована: Сен. 1, 2023
Hepatic
ischemia-reperfusion
injury
(HIRI)
is
mainly
responsible
for
morbidity
or
death
due
to
graft
rejection
after
liver
transplantation.
During
HIRI,
superoxide
anion
(O2•-)
and
adenosine-5'-triphosphate
(ATP)
have
been
identified
as
pivotal
biomarkers
associated
with
oxidative
stress
energy
metabolism,
respectively.
However,
how
the
temporal
spatial
fluctuations
of
O2•-
ATP
coordinate
changes
in
HIRI
particularly
they
synergistically
regulate
each
other
pathological
mechanism
remains
unclear.
Herein,
we
rationally
designed
successfully
synthesized
a
dual-color
dual-reversible
molecular
fluorescent
probe
(UDP)
dynamic
simultaneous
visualization
real-time,
uncovered
their
interrelationship
synergy
HIRI.
UDP
featured
excellent
sensitivity,
selectivity,
reversibility
response
ATP,
which
rendered
suitable
detecting
generating
independent
responses
blue
red
fluorescence
channels
without
spectral
crosstalk.
Notably,
situ
imaging
revealed
first
time
synchronous
bursts
depletion
hepatocytes
mouse
livers
during
process
Surprisingly,
slight
increase
was
observed
reperfusion.
More
importantly,
intracellular
O2•-─succinate
dehydrogenase
(SDH)─mitochondrial
(Mito)
reduced
nicotinamide
adenine
dinucleotide
(NADH)─Mito
ATP─intracellular
cascade
signaling
pathway
unveiled
illustrated
correlation
between
time.
This
research
confirms
potential
monitoring
provides
clear
illustration
pathogenesis.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(18), С. 6447 - 6496
Опубликована: Янв. 1, 2023
This
review
highlights
the
use
of
nanoprobes
to
stratify
various
therapeutic
modalities
and
provides
an
outlook
on
challenges
future
directions
for
patient
stratification.
ACS Nano,
Год журнала:
2024,
Номер
18(20), С. 13019 - 13034
Опубликована: Май 9, 2024
Photodynamic
therapy
(PDT)
and
photothermal
(PTT)
possess
different
merits
in
cancer
phototherapy,
but
the
tumor
microenvironment
becomes
unfavorable
during
phototheranostic
progress.
Herein,
we
report
a
self-adaptive
cyanine
derivative
Cy5-TPA
with
PDT-dominated
state
to
PTT-dominated
autoswitch
feature
for
enhanced
photoimmunotherapy.
The
incorporation
of
rotatable
triphenylamine
(TPA)
moiety
renders
temperature
or
intramolecular-motion
regulated
photoactivities,
which
shows
preferable
reactive
oxygen
species
(ROS)
generation
at
lower
while
stronger
conversion
higher
ones.
Such
promising
permits
situ
switch
from
along
intratumoral
increase
laser
irradiation,
also
works
line
concurrently
reduced
level,
exhibiting
phototherapeutic
behavior
maximize
antitumor
outcome.
Most
importantly,
facilitates
sequential
release
damage-associated
molecular
patterns
immunogenic
cell
death
(ICD).
Hence,
demonstrates
excellent
photoimmunotherapy
performance
ICD
induction,
dendritic
maturation,
T
activation
eradication
metastasis
inhibition.
