“Two-birds-one-stone” oral nanotherapeutic designed to target intestinal integrins and regulate redox homeostasis for UC treatment DOI Creative Commons
Long Huang, Wei Hu,

Long Qun Huang

и другие.

Science Advances, Год журнала: 2024, Номер 10(30)

Опубликована: Июль 24, 2024

Designing highly efficient orally administrated nanotherapeutics with specific inflammatory site-targeting functions in the gastrointestinal tract for ulcerative colitis (UC) management is a noteworthy challenge. Here, we focused on exploring targeting oral nanotherapy, serving as "one stone," directed localization of inflammation and regulation redox homeostasis, thereby achieving effects against "two birds" UC treatment. Our designed nanotherapeutic agent OPNs@LMWH (oxidation-sensitive ε-polylysine nanoparticles at low-molecular weight heparin) exhibited active therapeutic efficacy simultaneously. results indicate that had high integrin αM-mediated immune cellular uptake efficiency preferentially accumulated inflamed tissues. We also confirmed its effectiveness treatment experiment mice by ameliorating oxidative stress inhibiting activation inflammation-associated signaling pathways while simultaneously bolstering protective mechanisms colonic epithelium. Overall, these findings underscore compelling dual functionalities OPNs@LMWH, which enable effective delivery to sites, facilitating precise management.

Язык: Английский

Polymeric nanoparticles (PNPs) for oral delivery of insulin DOI Creative Commons
Yunyun Wang, Hao Li, Aamir Rasool

и другие.

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Янв. 3, 2024

Abstract Successful oral insulin administration can considerably enhance the quality of life (QOL) diabetes patients who must frequently take injections. Oral administration, on other hand, is seriously hampered by gastrointestinal enzymes, wide pH range, mucus and mucosal layers, which limit bioavailability to ≤ 2%. Therefore, a large number technological solutions have been proposed increase insulin, in polymeric nanoparticles (PNPs) are highly promising for delivery. The recently published research articles chosen this review based applications PNPs with strong future potential delivery, do not cover all related work. In review, we will summarize controlled release mechanisms latest delivery nanocarrier, challenges prospect. This serve as guide investigators wish engineer study systems. Graphical

Язык: Английский

Процитировано

60
Waste to Wealth: Near-Infrared/pH Dual-Responsive Copper-Humic Acid Hydrogel Films for Bacteria-Infected Cutaneous Wound Healing DOI
Kangkang Zha, Yuan Xiong, Wenqian Zhang

и другие.

ACS Nano, Год журнала: 2023, Номер 17(17), С. 17199 - 17216

Опубликована: Авг. 25, 2023

The clinical applications of currently used photosensitizers are limited by high costs, inconvenient preparation, suboptimal biodegradability, and a lack biological activity. Humic acids (HAs) show photothermal activity can be as photosensitizer for therapy. In the presence various functional groups, HAs endowed with anti-inflammatory antioxidant activities. solubility is dependent on pH value, which soluble in neutral to alkaline conditions undergoes conformational change coiled compact structure acidic conditions. Additionally, Cu2+ an emerging therapeutic agent cutaneous wounds chelated form complexes. this study, we explore ability modulate inflammatory response, particularly macrophage polarization, potential underlying mechanism. We fabricate near-infrared (NIR)/pH dual-responsive Cu-HAs nanoparticle (NP)-based poly(vinyl alcohol) (PVA) hydrogel film loaded SEW2871 (SEW), recruitment agent, treat bacteria-infected wounds. results that could promote M2 polarization dose-dependent manner. NPs successfully eradicated bacterial infection through NIR-induced local hyperthermia. This PVA@Cu-HAs NPs@SEW improves tissue regeneration promoting alleviating oxidative stress, enhancing angiogenesis, facilitating collagen deposition. These findings highlight treatment bacterially infected wound healing.

Язык: Английский

Процитировано

57
Advances in Hydrogel-Based Drug Delivery Systems DOI Creative Commons
Boya Liu, Kuo Chen

Gels, Год журнала: 2024, Номер 10(4), С. 262 - 262

Опубликована: Апрель 13, 2024

Hydrogels, with their distinctive three-dimensional networks of hydrophilic polymers, drive innovations across various biomedical applications. The ability hydrogels to absorb and retain significant volumes water, coupled structural integrity responsiveness environmental stimuli, renders them ideal for drug delivery, tissue engineering, wound healing. This review delves into the classification based on cross-linking methods, providing insights synthesis, properties, We further discuss recent advancements in hydrogel-based delivery systems, including oral, injectable, topical, ocular approaches, highlighting significance enhancing therapeutic outcomes. Additionally, we address challenges faced clinical translation propose future directions leveraging potential personalized medicine regenerative healthcare solutions.

Язык: Английский

Процитировано

50
Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application DOI
Liang Chen, Shanshan Zhang,

Yanqiu Duan

и другие.

Chemical Society Reviews, Год журнала: 2024, Номер 53(3), С. 1167 - 1315

Опубликована: Янв. 1, 2024

Silicon-based biomaterials have been extensively developed in the past decades. The classification, characteristics, multi-dimensional design, and biomedical applications of silicon-containing are comprehensively elaborated.

Язык: Английский

Процитировано

39
A Gas Therapy Strategy for Intestinal Flora Regulation and Colitis Treatment by Nanogel‐Based Multistage NO Delivery Microcapsules DOI
Yajun Fu, Xing Zhao, Liya Wang

и другие.

Advanced Materials, Год журнала: 2024, Номер 36(19)

Опубликована: Фев. 7, 2024

Current approaches to treating inflammatory bowel disease focus on the suppression of overactive immune responses, removal reactive intestinal oxygen species, and regulation flora. However, owing complex structure gastrointestinal tract influence mucus, current small-molecule biologic-based drugs for colitis cannot effectively act at site colon inflammation, as a result, they tend exhibit low efficacies toxic side effects. In this study, nanogel-based multistage NO delivery microcapsules are developed achieve release inflammation by targeting tissues using nanogel. Surprisingly, oral administration suppresses growth pathogenic bacteria increases abundance probiotic bacteria. Metabolomics further show that an increased probiotics promotes production metabolites, including short-chain fatty acids indole derivatives, which modulate immunity restore barrier via interleukin-17 PI3K-Akt signaling pathways. This work reveals gas therapy strategy based modulates microbial balance, thereby reducing promoting repair, ultimately providing new therapeutic approach clinical management colitis.

Язык: Английский

Процитировано

30
Polyphenolic Nanoparticle-Modified Probiotics for Microenvironment Remodeling and Targeted Therapy of Inflammatory Bowel Disease DOI
Qinglian Hu, Jingyu Li, Tong Wang

и другие.

ACS Nano, Год журнала: 2024, Номер 18(20), С. 12917 - 12932

Опубликована: Май 9, 2024

Inflammatory bowel diseases (IBDs) refer to multifaceted disorders in the intestinal microenvironment and microbiota homeostasis. In view of broad bioactivity high compatibility polyphenols, there is considerable interest developing a polyphenol-based collaborative platform remodel IBD regulate microbiota. Here, we demonstrated coordination assembly nanostructured polyphenols modify probiotics simultaneously deliver drugs for treatment. Inspired by distinctive structure tannic acid (TA), fabricated pBDT-TA using self-polymerizable aromatic dithiol (BDT) TA, which exhibited excellent antioxidant anti-inflammatory capability vitro. We thus coated sodium alginate (SA) surface Escherichia coli Nissle 1917 layer construct EcN@SA-pBDT-TA. The modified showed improved resistance oxidative inflammatory stress, resulted superior colon accumulation retention model mice. Further, EcN@SA-pBDT-TA could alleviate dextran sulfate (DSS)-induced colitis controlling response, repairing barriers, modulating gut Importantly, EcN@SA-pBDT-TA-mediated drug delivery achieve an therapeutic effect DSS Given availability functionality polyphenol prebiotics, expected that polyphenol-modified provided solution develop

Язык: Английский

Процитировано

30
A singular plasmonic-thermoelectric hollow nanostructure inducing apoptosis and cuproptosis for catalytic cancer therapy DOI Creative Commons

Lu Yang,

Zhiyu Zhao, Boshi Tian

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Авг. 29, 2024

Thermoelectric technology has recently emerged as a distinct therapeutic modality. However, its effectiveness is significantly limited by the restricted temperature gradient within living organisms. In this study, we introduce high-performance plasmonic-thermoelectric catalytic therapy utilizing urchin-like Cu

Язык: Английский

Процитировано

26
Rapid Selenoprotein Activation by Selenium Nanoparticles to Suppresses Osteoclastogenesis and Pathological Bone Loss DOI
Binhua Zou,

Zushuang Xiong,

Yanzi Yu

и другие.

Advanced Materials, Год журнала: 2024, Номер 36(27)

Опубликована: Апрель 15, 2024

Abstract Osteoclast hyperactivation stands as a significant pathological factor contributing to the emergence of bone disorders driven by heightened oxidative stress levels. The modulation redox balance scavenge reactive oxygen species emerges viable approach addressing this concern. Selenoproteins, characterized selenocysteine (SeCys 2 ) active center, are crucial for selenium‐based antioxidative therapy inflammatory diseases. This study reveals that surface‐active elemental selenium (Se) nanoparticles, particularly lentinan‐Se (LNT‐Se), exhibit enhanced cellular accumulation and accelerated metabolism SeCys , primary Se form in biological systems. Consequently, LNT‐Se demonstrates inhibition osteoclastogenesis. Furthermore, vivo studies underscore superior therapeutic efficacy over potentially attributable stability safety profile LNT‐Se. Specifically, effectively modulates expression selenoprotein GPx1, thereby exerting regulatory control osteoclastogenesis inhibition, prevention osteolysis. In summary, these results suggest prompt activation selenoproteins nanoparticles serves suppress loss upregulating GPx1. Moreover, utilization bioactive presents promising avenue managing disorders.

Язык: Английский

Процитировано

25
Selenoprotein‐Regulated Hydrogel for Ultrasound‐Controlled Microenvironment Remodeling to Promote Bone Defect Repair DOI
Renhao Xu,

Yuanyuan You,

Wenyi Zheng

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер 34(12)

Опубликована: Янв. 14, 2024

Abstract Abnormal levels of reactive oxygen species (ROS) and the hypoxic microenvironment within bone defects are important factors that impede repair processes. Herein, an innovative ultrasound‐modulatable hydrogel platform with selenoprotein‐mediated antioxidant effects to promote injury is presented. This encapsulates oxygen‐enriched selene‐incorporated thin‐shell silicon methacrylate gelatin (O 2 ‐PSSG). The resultant construct orchestrates modulation bone‐defect microenvironment, thereby expediting course regeneration. Ultrasound (US) used regulate pore size release selenium‐containing nanoparticles in situ synthesis efficient intracellular selenoproteins hydrogen peroxide consumption. As expected, O ‐PSSG rapidly releases selenocystine ([Sec] ) under US control scavenge maintain homeostasis marrow mesenchymal stem cells (BMSCs). Over time, action system by selenoprotein increases activation Wnt/β‐catenin pathways promotes differentiation BMSCs. Consequently, potentiates proficiency BMSCs both vitro vivo, alleviates environments, osteogenic differentiation, expedites cranial rat models. In summary, this study suggests designed constructed US‐responsive a promising prospective strategy for addressing fostering

Язык: Английский

Процитировано

21
Recent advances in bacteria‐based platforms for inflammatory bowel diseases treatment DOI Creative Commons

Jiaoying Lu,

Xinyuan Shen,

Hongjun Li

и другие.

Exploration, Год журнала: 2024, Номер 4(5)

Опубликована: Март 5, 2024

Abstract Inflammatory bowel disease (IBD) is a recurring chronic inflammatory disease. Current treatment strategies are aimed at alleviating clinical symptoms and associated with gastrointestinal or systemic adverse effects. New delivery needed for the of IBD. Bacteria promising biocarriers, which can produce drugs in situ sense gut real time. Herein, we focus on recent studies engineered bacteria used IBD introduce application diagnosis. On this basis, current dilemmas future developments bacterial systems discussed.

Язык: Английский

Процитировано

19