Harnessing Nanotheranostics‐Based Dendritic Cells Tracking Mature Tertiary Lymphoid Structures to Boost Anti‐Glioma Immunotherapy DOI Open Access
Rong Zhang, Teng Jin, Yan Ren

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 21, 2025

Abstract Anti‐glioma immunotherapy is highly challenging, largely due to poor immune infiltration and restricted delivery, resulting in patient prognosis. Recent studies suggest that mature tertiary lymphoid structures (mTLSs) promote cell into solid tumors, associated with enhanced response better However, the formation visualization of mTLSs becomes extremely difficult from lack tissue microenvironment brain parenchyma. Herein, theranostic nanoprobes consisting FITC‐HFe₃O₄@Gd (MRI/FI tracer) internally loaded chemokines CXCL13 CCL12 are specifically designed be internalized by dendritic cells (DCs) biomimetic nanosystem. Subsequently, labeled DCs integrated follicular (fDC) network crossing high endothelial venules (HEVs), enabling noninvasive (e.g., maturation, location, density) DC tracer technology. Interestingly, released stimulate generation “immune trafficking bridge” centripetal redistribution effector lymphocytes (B220⁺ B CD8⁺ T cells) within glioma, thereby further enhancing adaptive responses effectively inhibiting glioma progression vivo. Consequently, this innovative nanostrategy combining MRI/FI tracing enables assessment prediction beneficial for clinical translation.

Язык: Английский

A spatial confinement biological heterogeneous cascade nanozyme composite hydrogel combined with nitric oxide gas therapy for enhanced treatment of psoriasis and diabetic wound DOI
Yuying Zhang, Cunpeng Nie, Zishu Wang

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160629 - 160629

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
Challenges and Material Innovations in Drug Delivery to Central Nervous System Tumors DOI
Zhenyu Gong,

Dairan Zhou,

Dejun Wu

и другие.

Biomaterials, Год журнала: 2025, Номер 319, С. 123180 - 123180

Опубликована: Фев. 13, 2025

Язык: Английский

Процитировано

1
Strong interaction between plasmon and topological surface state in Bi 2 Se 3 /Cu 2- x S nanowires for solar-driven photothermal applications DOI Creative Commons
Yang Liu,

S. S. Pan,

Wenxi Xia

и другие.

Science Advances, Год журнала: 2025, Номер 11(11)

Опубликована: Март 12, 2025

Developing high-performance photothermal materials and unraveling the underlying mechanism are essential for applications. Here, performance improved by strong interaction between plasmon topological surface state (TSS) is demonstrated in Bi 2 Se 3 /Cu 2- x S nanowires. This hybrid, which Cu nanosheets were grown on nanowires, leverages resonance TSS-induced optical property, generating wide efficient light absorption. A series of tests reveals coupling, hot electron injection, plasmon-induced hole relaxation within hybrids, endowing with excellent performance. By integrating hybrids into a hydrogel thermoelectric module, evaporator achieves remarkable water evaporation rate 3.67 kilograms per square meter hour solar-to-vapor efficiency 95.2%, maximum output power 1.078 watts under simulated sunlight irradiation. Moreover, conical mirror was introduced to device, greatly enhances without additional energy input.

Язык: Английский

Процитировано

0
Harnessing Nanotheranostics‐Based Dendritic Cells Tracking Mature Tertiary Lymphoid Structures to Boost Anti‐Glioma Immunotherapy DOI Open Access
Rong Zhang, Teng Jin, Yan Ren

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 21, 2025

Abstract Anti‐glioma immunotherapy is highly challenging, largely due to poor immune infiltration and restricted delivery, resulting in patient prognosis. Recent studies suggest that mature tertiary lymphoid structures (mTLSs) promote cell into solid tumors, associated with enhanced response better However, the formation visualization of mTLSs becomes extremely difficult from lack tissue microenvironment brain parenchyma. Herein, theranostic nanoprobes consisting FITC‐HFe₃O₄@Gd (MRI/FI tracer) internally loaded chemokines CXCL13 CCL12 are specifically designed be internalized by dendritic cells (DCs) biomimetic nanosystem. Subsequently, labeled DCs integrated follicular (fDC) network crossing high endothelial venules (HEVs), enabling noninvasive (e.g., maturation, location, density) DC tracer technology. Interestingly, released stimulate generation “immune trafficking bridge” centripetal redistribution effector lymphocytes (B220⁺ B CD8⁺ T cells) within glioma, thereby further enhancing adaptive responses effectively inhibiting glioma progression vivo. Consequently, this innovative nanostrategy combining MRI/FI tracing enables assessment prediction beneficial for clinical translation.

Язык: Английский

Процитировано

0