Boosting Cancer Cell Ferroptosis with Carbon Monoxide Poisoned Hemoglobin

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Май 7, 2025

The peroxidase (POD)-like nanozymes, particularly those with atomic Fe-Nx sites, have demonstrated exceptional catalytic potential in cancer cell ferroptosis. biodegradable hemoglobin (Hb) is recognized as an Fe-N5 POD-like nanozyme expected to replace the carbon-based ones, while its uncontrollable reaction remains a safety concern. Here, inspired by carbon monoxide (CO) poisoned Hb, we develop controllable and nanoplatform DPHCO which integrates carboxyhemoglobin (HbCO) platinum(IV) prodrug into -CH2SSCH2- bridged dendritic mesoporous organosilica nanoparticles (DMON). site of HbCO could be temporarily deactivated during blood circulation. In tumor tissue, will situ reactivated H2O2-driven valence modulation heme iron, along CO desorption. Hb performs activity ferric-ferryl redox cycle, adhering Michaelis-Menten kinetics density function theory (DFT) calculation results. Both vitro vivo data suggest that released induce lipid peroxidation ferroptosis, further boosted cisplatin synergy. This gas modification iron valence-driven provide feasible approach for toggling "OFF/ON" site, would inspire development nanozymes precision oncotherapy.

Язык: Английский

Icosahedral carboranes-based metal nanoclusters: From fascinating structures to polychrome properties and applications

Coordination Chemistry Reviews, Год журнала: 2025, Номер 542, С. 216803 - 216803

Опубликована: Июнь 2, 2025

Язык: Английский