Human VMPFC encodes early signatures of confidence in perceptual decisions

eLife, Год журнала: 2018, Номер 7

Опубликована: Сен. 24, 2018

Choice confidence, an individual's internal estimate of judgment accuracy, plays a critical role in adaptive behaviour, yet its neural representations during decision formation remain underexplored. Here, we recorded simultaneous EEG-fMRI while participants performed direction discrimination task and rated their confidence on each trial. Using multivariate single-trial discriminant analysis the EEG, identified stimulus-independent component encoding which appeared prior to subjects' explicit choice report, was consistent with measure predicted by accumulation-to-bound model decision-making. Importantly, trial-to-trial variability this electrophysiologically-derived signal uniquely associated fMRI responses ventromedial prefrontal cortex (VMPFC), region not typically for perceptual decisions. Furthermore, activity VMPFC functionally coupled regions frontal linked decision-making metacognition. Our results suggest that holds early representation arising from dynamics, preceding potentially informing metacognitive evaluation.

Язык: Английский

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Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains

eLife, Год журнала: 2020, Номер 9

Опубликована: Июнь 16, 2020

Decisions are often made by accumulating ambiguous evidence over time. The brain’s arousal systems activated during such decisions. In previous work in humans, we found that evoked responses of decisions reported rapid dilations the pupil and track a suppression biases accumulation decision-relevant (de Gee et al., 2017). Here, show this arousal-related decision bias acts on both conservative liberal biases, generalizes from humans to mice, perceptual memory-based challenging sound-detection tasks, impact spontaneous or experimentally induced choice was reduced under high phasic arousal. Similar occurred when drawn memory. All these behavioral effects were explained biases. Our results point general principle interplay between decision-making.

Язык: Английский

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Reinforcement biases subsequent perceptual decisions when confidence is low, a widespread behavioral phenomenon

eLife, Год журнала: 2020, Номер 9

Опубликована: Апрель 14, 2020

Learning from successes and failures often improves the quality of subsequent decisions. Past outcomes, however, should not influence purely perceptual decisions after task acquisition is complete since these are designed so that only sensory evidence determines correct choice. Yet, numerous studies report outcomes can bias decisions, causing spurious changes in choice behavior without improving accuracy. Here we show effects reward on principled: past rewards future choices specifically when previous was difficult hence decision confidence low. We identified this phenomenon six datasets four laboratories, across mice, rats, humans, modalities olfaction audition to vision. choice-updating strategy be explained by reinforcement learning models incorporating statistical into their teaching signals. Thus, mechanisms continually engaged produce systematic adjustments even well-learned order optimize an uncertain world.

Язык: Английский

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Statistical context dictates the relationship between feedback-related EEG signals and learning

eLife, Год журнала: 2019, Номер 8

Опубликована: Авг. 21, 2019

Learning should be adjusted according to the surprise associated with observed outcomes but calibrated statistical context. For example, when occasional changepoints are expected, surprising weighted heavily speed learning. In contrast, uninformative outliers expected occur occasionally, less influential. Here we dissociate from degree which they demand learning using a predictive inference task and computational modeling. We show that P300, stimulus-locked electrophysiological response previously adjustments in behavior, does so conditionally on source of surprise. Larger P300 signals predicted greater changing context, context where was indicative one-off outlier (oddball). Our results suggest provides signal is interpreted by downstream processes differentially order appropriately calibrate across complex environments.

Язык: Английский

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An Accumulation-of-Evidence Task Using Visual Pulses for Mice Navigating in Virtual Reality

Frontiers in Behavioral Neuroscience, Год журнала: 2018, Номер 12

Опубликована: Март 6, 2018

The gradual accumulation of sensory evidence is a crucial component perceptual decision making, but its neural mechanisms are still poorly understood. Given the wide availability genetic and optical tools for mice, they can be useful model organisms study these phenomena; however, behavioral largely lacking. Here, we describe new evidence-accumulation task head-fixed mice navigating in virtual reality (VR) environment. As navigate down stem T-maze, see brief pulses visual on either side, retrieve reward arm with highest number pulses. occur randomly Poisson statistics, yielding diverse yet well-controlled stimulus set, making data conducive to variety computational approaches. A large different genotypes were able learn consistently perform task, at levels similar rats analogous tasks. They sensitive side differences single pulse, their memory cues stable over time. Moreover, using non-parametric as well modeling approaches, show that indeed accumulate evidence: use multiple from throughout cue region maze make decision, albeit small overweighting earlier cues, performance affected by magnitude not duration evidence. Additionally, analysis mice's running patterns revealed trajectories fairly stereotyped modulated amount evidence, suggesting navigational this may provide continuous readout correlated underlying cognitive variables. Our which readily integrated state-of-the-art techniques, thus valuable tool circuit dynamics particularly under more complex contexts.

Язык: Английский

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