Circular RNA profiling reveals that circular RNAs from ANXA2 can be used as new biomarkers for multiple sclerosis

Human Molecular Genetics, Год журнала: 2017, Номер 26(18), С. 3564 - 3572

Опубликована: Июнь 22, 2017

Multiple sclerosis is an autoimmune disease, with higher prevalence in women, whom the immune system dysregulated. This dysregulation has been shown to correlate changes transcriptome expression as well gene-expression regulators, such non-coding RNAs (e.g. microRNAs). Indeed, some of these have suggested biomarkers for multiple even though few reached clinical practice. Recently, a novel family RNAs, circular emerged new player complex network regulation. MicroRNA regulation function through 'sponge system' and RNA splicing proposed RNAs. regulating role together their high stability biofluids makes them seemingly good candidates biomarkers. Given both protein-coding that reported patients, we hypothesised may also be altered. Therefore, carried out profiling 13.617 peripheral blood leucocytes from patients healthy controls finding 406 differentially expressed (P-value < 0.05, Fold change > 1.5) demonstrate after validation that, circ_0005402 circ_0035560 are underexpressed could used disease.

Язык: Английский

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Regulation of brain microglia by female gonadal steroids

The Journal of Steroid Biochemistry and Molecular Biology, Год журнала: 2014, Номер 146, С. 3 - 14

Опубликована: Март 4, 2014

Язык: Английский

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The Multiple Sclerosis Genomic Map: Role of peripheral immune cells and resident microglia in susceptibility

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2017, Номер unknown

Опубликована: Июль 13, 2017

Abstract: We assembled and analyzed genetic data of 47,351 multiple sclerosis (MS) subjects 68,284 control establish a reference map the architecture MS that includes 200 autosomal susceptibility variants outside major histocompatibility complex (MHC), one chromosome X variant, 32 independent associations within extended MHC. used an ensemble methods to prioritize up 551 potentially associated genes, implicate innate adaptive pathways distributed across cellular components immune system. Using expression profiles from purified human microglia, we do find enrichment for genes in these brain - resident cells. Thus, while is most likely initially triggered by perturbation peripheral responses functional microglia other cells are also altered may have role targeting autoimmune process central nervous One Sentence Summary: report detailed genomic sclerosis, describe putatively affected system microglia.

Язык: Английский

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Male-specific IL-33 expression regulates sex-dimorphic EAE susceptibility

Proceedings of the National Academy of Sciences, Год журнала: 2018, Номер 115(7)

Опубликована: Янв. 29, 2018

Significance Women are much more likely to develop autoimmune diseases, such as systemic lupus erythematous, rheumatoid arthritis, and multiple sclerosis. Sex hormones, including estrogen testosterone, clearly influence disease susceptibility, but the precise cellular molecular targets of these hormones have remained unexplained. While most studies focused on what causes damaging inflammation in females, there is also be learned by studying factors that confer protection males. Using a mouse model sclerosis, CNS demyelinating disease, we identified testosterone-driven pathway mediated mast cell-dependent IL-33 expression limits development destructive immune response The identification pathways has important therapeutic implications.

Язык: Английский

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Pregnancy: Effect on Multiple Sclerosis, Treatment Considerations, and Breastfeeding

Neurotherapeutics, Год журнала: 2017, Номер 14(4), С. 974 - 984

Опубликована: Авг. 1, 2017

Язык: Английский

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