Chemistry,
Год журнала:
2025,
Номер
7(2), С. 61 - 61
Опубликована: Апрель 11, 2025
Biomaterials
and
biomembranes
play
a
crucial
role
in
variety
of
applications,
particularly
the
medical
field
due
to
their
ability
mimic
natural
biological
structures
functions.
Crosslinkers
also
an
important
enhancing
structural
integrity
functionality
biomaterials
design
biomembranes.
This
review
article
explores
fundamentals
biomembranes,
with
particular
focus
on
crosslinkers
biology,
chemistry
medicine.
We
explore
various
types
commonly
used
synthesis,
examining
chemical
structure,
classification,
synthesis
methods.
Additionally,
we
analyze
properties
interactions,
highlighting
impact,
cellular
behavior
cytotoxicity.
further
emphasizes
recent
advances
innovation,
tissue
engineering,
drug
delivery,
wound
healing.
Finally,
conclude
by
addressing
current
challenges
suggesting
potential
futures
directions
for
research
this
field.
Biomaterials Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
3D
bioprinted
PLA
scaffolds
with
curcumin-loaded
lipid
carriers
show
antimicrobial
activity
and
promote
skin
regeneration,
offering
promise
for
wound
healing.
Materials Today Bio,
Год журнала:
2024,
Номер
26, С. 101098 - 101098
Опубликована: Май 22, 2024
Developing
patches
that
effectively
merge
intrinsic
deformation
characteristics
of
cardiac
with
superior
tunable
mechanical
properties
remains
a
crucial
biomedical
pursuit.
Currently
used
traditional
block-shaped
or
mesh
patches,
typically
incorporating
positive
Poisson's
ratio,
often
fall
short
matching
the
tissue
satisfactorily,
thus
diminishing
their
repairing
capability.
By
introducing
auxeticity
into
this
study
is
trying
to
present
beneficial
approach
address
these
shortcomings
patches.
The
featuring
auxetic
effect,
offer
unparalleled
conformity
complex
challenges.
Initially,
scaffolds
demonstrating
effect
were
designed
by
merging
chiral
rotation
and
concave
angle
units,
followed
integrating
composite
hydrogel
through
thermally
triggering,
ensuring
excellent
biocompatibility
closely
mirroring
heart
tissue.
Tensile
tests
revealed
possessed
elasticity
strain
capacity
exceeding
tissue's
physiological
activity.
Notably,
Model
III
showed
an
equivalent
modulus
ratio
toward
tissue,
underscoring
its
outstanding
potential
as
Cyclic
tensile
loading
demonstrated
withstood
continuous
heartbeats,
showcasing
cyclic
recovery
capabilities.
Numerical
simulations
further
elucidated
failure
mechanisms
leading
exploration
influence
on
alternative
design
parameters,
which
enabled
customization
strength
ratio.
Therefore,
research
presents
substantial
for
designing
can
emulate
possess
adjustable
parameters.
Advanced Materials,
Год журнала:
2024,
Номер
36(32)
Опубликована: Май 27, 2024
Citrate-based
biodegradable
polymers
have
emerged
as
a
distinctive
biomaterial
platform
with
tremendous
potential
for
diverse
medical
applications.
By
harnessing
their
versatile
chemistry,
these
exhibit
wide
range
of
material
and
bioactive
properties,
enabling
them
to
regulate
cell
metabolism
stem
differentiation
through
energy
metabolism,
metabonegenesis,
angiogenesis,
immunomodulation.
Moreover,
the
recent
US
Food
Drug
Administration
(FDA)
clearance
poly(octamethylene
citrate)
(POC)/hydroxyapatite-based
orthopedic
fixation
devices
represents
translational
research
milestone
science.
POC
joins
short
list
synthetic
that
ever
been
authorized
by
FDA
use
in
humans.
The
clinical
success
has
sparked
enthusiasm
accelerated
development
next-generation
citrate-based
biomaterials.
This
review
presents
comprehensive,
forward-thinking
discussion
on
pivotal
role
citrate
chemistry
various
tissue
regeneration
functional
metabotissugenic
biomaterials
regenerative
engineering
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Год журнала:
2024,
Номер
157, С. 106661 - 106661
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 26, 2024
Abstract
Electrospinning
is
a
significant
manufacturing
strategy
to
create
micro/nanofiber
platforms
that
can
be
considered
biomedical
scaffold
for
tissue
engineering
repair
and
regeneration.
In
recent
years
researchers
have
continuously
broadened
the
equipment
design
materials
development
of
electrospinning
nanofiber
(ENPs),
which
evolved
from
single‐needle
multi‐needle
creating
3D
ENPs,
diversify
their
application
including
drugs/cell/growth
factors
release,
anti‐bacterial
anti‐inflammatory,
hemostasis,
wound
healing,
Herein,
multifunctional
ENPs
with
bioactive
polymer
fabricated
via
in
terms
novel
material
design,
construction
various
structures,
requirements
different
regeneration
are
reviewed.
Furthermore,
this
review
delves
into
advancements
facilitated
by
highlighting
effectiveness
versatility
across
types
such
as
bone,
cartilage,
tendons,
cardiac
tissue,
nerves.
The
discussion
comprehensively
addresses
ongoing
challenges
selection,
biodegradation
mechanisms,
bioactivation
strategies,
techniques
specific
applications.
Moreover,
outlines
potential
future
research
avenues
aimed
at
enhancing
ENPs‐based
approaches
engineering.
This
in‐depth
analysis
aims
provide
nuanced
insights
technical
recommendations
propel
field
forward
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 16, 2024
Abstract
Diabetic
foot
ulcers
(DFU)
are
notoriously
challenging
to
heal
due
severe
infection,
excessive
inflammation,
and
difficulty
in
angiogenesis.
In
response
these
problems,
first,
a
pH/glucose
dual‐responsive
hydrogel
dressing
(HPC)
is
constructed
using
dual
dynamic
crosslinking
through
Schiff
base
phenylboronate
ester
between
m‐aminophenylboronic
acid
adipic
dihydrazide
bifunctionalized
hyaluronic
(AHP)
oxidized
chondroitin
sulfate
(OCS).
Then,
polydopamine‐reduced
graphene
oxide
compounded
glycine‐modified
fullerene
(GPC)
with
photothermal/photodynamic
synergistic
antibacterial
properties
the
drug
pirfenidone
(PFD)
pro‐angiogenesis
suppress
inflammatory
loaded
into
above
HPC
hydrogel.
Based
on
of
base/phenylboronate
pH/glucose,
HPC/GPC/PFD
(HPCG/PFD)
can
accelerate
release
PFD,
thereby
improving
inflammation
angiogenesis
DFU.
addition,
provided
good
on‐demand
removal
self‐healing
performance,
while
GPC
brought
tissue
adhesion,
antioxidation,
electrical
conductivity
The
rheology,
morphology,
mechanical
properties,
swelling,
degradation,
biocompatibility
have
been
well
verified.
Finally,
DFU
model
rats,
this
promote
wound
repair
by
reducing
infection
accelerating
closure,
enhancing
epidermal
regeneration,
collagen
deposition,
angiogenesis,
showing
promoting
effect
diabetic
healing.
