Acta Obstetricia Et Gynecologica Scandinavica,
Год журнала:
2024,
Номер
103(6), С. 1083 - 1091
Опубликована: Март 19, 2024
Abstract
Introduction
Cannabis
potency
and
its
use
during
pregnancy
have
increased
in
the
last
decade.
The
aim
of
this
study
was
to
investigate
impact
antenatal
cannabis
on
fetal
growth,
preterm
birth
other
perinatal
outcomes.
Material
methods
A
propensity
score‐matched
analysis
performed
women
with
singleton
pregnancies
attending
a
tertiary
care
site
Barcelona.
Women
group
were
selected
based
results
detection
test.
Primary
outcomes
small
for
gestational
age
at
(SGA),
low
birthweight
birth.
Secondary
biometric
parameters
(neonatal
length
head
circumference),
respiratory
distress,
admission
neonatal
intensive
unit
breastfeeding
discharge.
second
excluding
confounders
(use
recreational
drugs
discontinuation
pregnancy)
performed.
Results
Antenatal
associated
higher
odds
ratio
SGA
(OR
3.60,
95%
CI:
1.68–7.69),
3.94,
2.17–7.13),
37
weeks
2.07,
1.12–3.84)
32
gestation
4.13,
1.06–16.11),
1.95,
1.03–3.71),
distress
2.77,
1.26–6.34),
lower
rates
discharge
0.10,
0.05–0.18).
When
confounders,
no
significant
association
between
found.
Conclusions
increases
risk
SGA,
birthweight,
adverse
However,
when
isolating
by
who
those
discontinue
pregnancy,
JAMA Internal Medicine,
Год журнала:
2024,
Номер
184(9), С. 1083 - 1083
Опубликована: Июль 22, 2024
Many
studies
have
evaluated
whether
in
utero
cannabis
exposure
is
associated
with
fetal
and
neonatal
outcomes,
yet
little
known
about
prenatal
use
maternal
health
outcomes
during
pregnancy.
Obstetrics and Gynecology,
Год журнала:
2023,
Номер
unknown
Опубликована: Авг. 10, 2023
OBJECTIVE:
To
understand
pregnant
patients'
reasons
for
prenatal
cannabis
use
and
perceptions
of
safety,
desired
undesirable
health
care
experiences,
information
about
secondarily
to
racial
differences
in
these
preferences.
METHODS:
We
conducted
a
qualitative
study
including
18
semi-structured,
race-concordant
virtual
focus
groups
with
individuals
who
self-reported
at
entry
large
integrated
system
Northern
California
from
November
2021
December
2021.
The
included
semi-structured
questions
that
were
recorded,
transcribed,
coded
by
the
research
team.
Thematic
analysis
was
used
analyze
data.
RESULTS:
Overall,
53
participants
included;
30
self-identified,
as
White
23
self-identified
Black.
Participants
averaged
30.3
years
age
(SD
5.2
years)
on
average
20.9
weeks
gestation
enrollment;
69.8%
reported
daily
use,
24.5%
weekly
5.7%
monthly
or
less
entrance
care.
Although
some
quit
early
pregnancy
because
concerns
potential
risks,
many
perceived
lack
scientific
evidence
believed
safe.
Many
preferred
over-the-counter
prescription
medications
treating
mood,
morning
sickness,
pain,
sleep.
valued
open
interactions
obstetricians
acknowledged
their
motivations
they
risks
through
conversations
educational
materials.
Black
participants'
perspectives
generally
similar,
but
few
uniquely
described
bias
related
use.
CONCLUSION:
Pregnant
patients
manage
mood
medical
symptoms,
safer
than
medications.
Obstetrician-initiated,
patient-centered
around
advice
discontinue
during
pregnancy,
exploration
willingness
switch
medically
recommended
interventions
pregnancy-related
symptoms
may
benefit
patients.
Journal of Cannabis Research,
Год журнала:
2024,
Номер
6(1)
Опубликована: Фев. 16, 2024
Our
primary
objective
was
to
understand
breastfeeding
individuals'
decisions
use
cannabis.
Specifically,
we
investigated
reasons
for
cannabis
use,
experiences
with
healthcare
providers
regarding
and
potential
concerns
about
use.
Breastfeeding Medicine,
Год журнала:
2024,
Номер
19(7), С. 515 - 524
Опубликована: Май 2, 2024
As
cannabis
use
increases
among
reproductive-aged
women,
there
is
a
growing
need
to
better
understand
the
presence
of
cannabinoids
in
milk
produced
by
women
using
cannabis.
It
unclear
how
concentrations
such
as
delta-9-tetrahydrocannabinol
(Δ
Journal of Neuroscience Research,
Год журнала:
2024,
Номер
102(7)
Опубликована: Июль 1, 2024
Abstract
Cannabis
consumption
has
increased
from
1.5%
to
2.5%
in
Canada
between
2012
and
2019.
Clinical
studies
have
indicated
effects
of
prenatal
cannabis
exposure
on
birth
weight,
substance
use,
neurodevelopmental
disorders,
but
are
confounded
by
several
difficult
control
variables.
Animal
models
allow
for
examination
the
mechanism
cannabis‐induced
changes
neurodevelopment
behavior,
while
controlling
dose
timing.
Several
animal
exist
which
provide
varying
levels
construct
validity,
dose,
maternal
stress.
Using
a
voluntary
oral
model,
mouse
dams
received
5
mg/kg
Δ9‐tetrahydrocannabinol
(THC)
whole
oil
peanut
butter
daily
gestational
day
1
(GD1)
postnatal
10
(PD10).
At
GD1,
GD18,
PD1,
PD10,
PD15,
plasma
was
collected;
pup
brains
were
collected
GD18
onward.
Pup
had
higher
THC
cannabidiol
at
each
time
point,
persisted
past
end
treatment
(PD15).
Male
female
adolescent
offspring
examined
ventral
tegmental
area
(VTA)
dopamine
neuron
activity
cocaine‐seeking
behavior.
Prenatal
early
(GD1–PD10)
cannabis‐exposed
male,
not
mice
decreased
gamma‐aminobutyric
acid
(GABAergic)
input,
depolarized
resting
membrane
potential,
spontaneous
firing
VTA
neurons.
Cannabis‐exposed
showed
faster
decay
N‐methyl‐D‐aspartate
(NMDA)
currents
both
sexes.
However,
no
differences
behavior
noted.
These
data
characterize
model
demonstrates
neuronal
is
disinhibited
offspring.
JAMA Health Forum,
Год журнала:
2024,
Номер
5(11), С. e243656 - e243656
Опубликована: Ноя. 1, 2024
It
is
unknown
whether
state
recreational
cannabis
legalization
(RCL)
related
to
increased
rates
of
prenatal
use
or
RCL-related
changes
vary
with
screening
methods
the
local
policy
environment.
Epigenomics,
Год журнала:
2023,
Номер
15(7), С. 453 - 473
Опубликована: Апрель 1, 2023
The
rate
of
substance
use
is
rising,
especially
among
reproductive-age
individuals.
Emerging
evidence
suggests
that
paternal
pre-conception
and
maternal
prenatal
may
alter
offspring
epigenetic
regulation
(changes
to
gene
expression
without
modifying
DNA)
outcomes
later
in
life,
including
neurodevelopment
mental
health.
However,
relatively
little
known
due
the
complexities
limitations
existing
studies,
making
causal
interpretations
challenging.
This
review
examines
contributions
influence
parental
on
gametes
potential
transmissibility
offspring's
epigenome
as
possible
areas
target
public
health
warnings
healthcare
provider
counseling
individuals
or
couples
periods
ultimately
mitigate
short-
long-term
morbidity
mortality.
