Fermented foods: Harnessing their potential to modulate the microbiota-gut-brain axis for mental health

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 158, С. 105562 - 105562

Опубликована: Янв. 25, 2024

Over the past two decades, whole food supplementation strategies have been leveraged to target mental health. In addition, there has increasing attention on ability of gut microbes, so called psychobiotics, positively impact behaviour though microbiota-gut-brain axis. Fermented foods offer themselves as a combined microbiota modulating intervention. Indeed, they contain potentially beneficial microbial metabolites and other bioactives, which are being harnessed axis for positive benefits. This review highlights diverse nature fermented in terms raw materials used type fermentation employed, summarises their potential shape composition microbiota, brain communication pathways including immune system and, ultimately, modulate Throughout, we identify knowledge gaps challenges faced designing human studies investigating health-promoting individual or components thereof. Importantly, also suggest solutions that can advance understanding therapeutic merit

Язык: Английский

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Metagenomic estimation of dietary intake from human stool

Nature Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Язык: Английский

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Digesting the complex metabolic effects of diet on the host and microbiome

Cell, Год журнала: 2024, Номер 187(15), С. 3857 - 3876

Опубликована: Июль 1, 2024

Язык: Английский

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Metagenomic estimation of dietary intake from human stool

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Фев. 6, 2024

Abstract Dietary intake is tightly coupled to gut microbiota composition, human metabolism, and the incidence of virtually all major chronic diseases. nutrient are usually quantified using dietary questionnaires, which tend focus on broad food categories, suffer from self-reporting biases, require strong compliance study participants. Here, we present MEDI (Metagenomic Estimation Intake): a method for quantifying food-derived DNA in stool metagenomes. We show that items can be accurately detected metagenomic shotgun sequencing data, even when at low abundances (>10 reads). Furthermore, how intake, terms abundance specific organisms, converted into detailed metabolic representation intake. could identify onset solid consumption infants it predicted questionnaire responses an adult population. Additionally, were able features associated with syndrome large clinical cohort, providing proof-of-concept quantification individual-specific patterns without need questionnaires.

Язык: Английский

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Fibre & fermented foods: differential effects on the microbiota-gut-brain axis

Proceedings of The Nutrition Society, Год журнала: 2024, Номер unknown, С. 1 - 16

Опубликована: Окт. 25, 2024

The ability to manipulate brain function through the communication between microorganisms in gastrointestinal tract and along gut-brain axis has emerged as a potential option improve cognitive emotional health. Dietary composition patterns have demonstrated robust capacity modulate microbiota-gut-brain axis. With their possess pre-, pro-, post-, synbiotic properties, dietary fibre fermented foods stand out potent shapers of gut microbiota subsequent signalling brain. Despite this potential, few studies directly examined mechanisms that might explain beneficial action on axis, thus limiting insight treatments for dysfunction. Herein, we evaluate differential effects from whole food sources functioning. Potential mediating health via are described. Although more multimodal research combines psychological assessments biological sampling compare each type is needed, evidence accumulated date suggests fibre, foods, and/or combination within psychobiotic diet can be cost-effective convenient approach functioning across lifespan.

Язык: Английский

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Biomarkers of food intake and their relevance to metabolic syndrome

Food & Function, Год журнала: 2024, Номер 15(14), С. 7271 - 7304

Опубликована: Янв. 1, 2024

To assess diet and the risk of metabolic syndrome, this review highlights food bioactives that are correlated with dietary intake. In addition, these have shown to impact systemic inflammation oxidative stress, among other.

Язык: Английский

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Design and reporting of prebiotic and probiotic clinical trials in the context of diet and the gut microbiome

Nature Microbiology, Год журнала: 2024, Номер 9(11), С. 2785 - 2794

Опубликована: Окт. 30, 2024

Язык: Английский

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Grocery intervention and DNA‐based assessment to improve diet quality in pediatric obesity: a pilot randomized controlled study

Obesity, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Abstract Objective We assessed the impact of a food‐provisioning intervention on diet quality in children with obesity. Methods Participants ( n = 33, aged 6–11 years) were randomly assigned to either usual care (intensive health behavior and lifestyle treatment) or (usual + food provisioning; high‐fiber, low‐dairy diet) for 4 weeks. The primary outcome was change child at Week 4. Secondary outcomes changes weight, insecurity, gut microbiome composition (16S ribosomal RNA), dietary intake, measured via an objective DNA‐based biomarker (i.e., FoodSeq). Genomic data analyzed against larger pediatric adolescent obesity cohort 195, 10–18 from similar households. Results Intervention demonstrated across all components more effective than increasing whole grain (β 0.20, 95% CI: 0.05 0.34; p 0.013) fiber 2.52, 1.28 3.76; < 0.001) decreasing dairy −1.31, −2.02 −0.60; 0.001). FoodSeq results, highly concordant grocery orders (adjusted R 2 0.65; 0.001), indicated shift toward low‐energy‐density plant taxa relative prior survey related 8.64, 5.18 12.14; No significant observed microbiome, insecurity. Conclusions Our study supports potential dietitian‐guided provisioning improving demonstrates genomic approach evaluating shifts.

Язык: Английский

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Molecular Barcoding the Rare Plants of Tennessee

Castanea, Год журнала: 2025, Номер 89(2)

Опубликована: Фев. 14, 2025

Язык: Английский

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Dietary plant diversity predicts early life microbiome maturation

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

Abstract Between birth and adulthood, the human gut is colonized by a complex microbial community. Despite established links between infant microbiome health, knowledge limited for how complementary feeding influences colonization. Using FoodSeq, an objective DNA-based dietary assessment technique, we analyzed 1,036 fecal samples from 729 children aged 0-3 years across countries in North America, Central Africa, Asia. We detected wide diversity of 199 unique plant food sequences, which only eight staple foods were consistently present all countries. this variation global diet, identified universal trajectories early life exposure: weaning stage, tracked with diversity, emerged as dominant signature populations. Still, did not correlate diversity. Instead, stage specifically predicted abundance adult-like bacterial taxa, including known fiber-degrading after age 1. Our findings support two-stage model maturation: phase dominated milk-adapted taxa independent feeding, followed maturation where diet shapes microbiota This suggests that tracking promoting may timely emergence microbiome.

Язык: Английский

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