An update on vitamin D signaling and cancer

Seminars in Cancer Biology, Год журнала: 2020, Номер 79, С. 217 - 230

Опубликована: Май 30, 2020

A low vitamin D status is associated with an increased risk of various cancers, such as colon, breast, prostate and hematological cells. The biologically most active metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) a high affinity ligand the transcription factor receptor (VDR). 1,25(OH)2D3 induces via VDR changes to epigenome healthy neoplastic cells in this way influences their transcriptome. Ligand-activated binds more than 10,000 loci within human genome affects some 1000 target genes large proportion tissues cell types. From evolutionary perspective, prime role was probably control energy metabolism later shifting modulate innate adaptive immunity well regulate calcium bone homeostasis. Since rapidly growing immune cancer both use same pathways for controlling proliferation, differentiation apoptosis, not surprisingly, signaling these processes also Thus, anti-cancer effects may derive from managing growth immunity. This review provides update on molecular basis signaling, i.e., transcriptome, its relationship prevention therapy.

Язык: Английский

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A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds

Redox Biology, Год журнала: 2017, Номер 14, С. 316 - 327

Опубликована: Сен. 30, 2017

The present review is a sequel to the previous on cancer metabolism published in this journal. This focuses selective antiproliferative and cytotoxic effects of mitochondria-targeted therapeutics (MTTs) cells. Emerging research reveals key role mitochondrial respiration tumor proliferation. Previously, nitroxide was shown selectively inhibit colon cell proliferation at submicromolar levels. centered therapeutic use MTTs their bioenergetic profiling Triphenylphosphonium cation conjugated parent molecule (e.g., vitamin-E or chromanol, ubiquinone, metformin) via linker alkyl chain considered an MTT. potently cells and, some cases, induce cytotoxicity. complex I activity stress through generation reactive oxygen species. combination with glycolytic inhibitors synergistically discusses how signaling molecules traditionally linked affect bioenergetics (glycolysis, TCA cycle, glutaminolysis).

Язык: Английский

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Signal Transduction Pathways in Breast Cancer: The Important Role of PI3K/Akt/mTOR

Journal of Oncology, Год журнала: 2020, Номер 2020, С. 1 - 11

Опубликована: Март 9, 2020

Breast cancer is the with highest prevalence in women and number-one cause of mortality worldwide. Cell transduction a fundamental process development progression cancer. Modifications various cell signalling pathways promote tumour proliferation, progression, survival. The PI3K/Akt/mTOR pathway an example that, it involved growth, survival, motility, metabolism, immune response regulation. Activation this one main causes resistance to antitumour therapies. This makes crucial object study for understanding disease. Thus, may have role as potential therapeutic target, well prognostic diagnostic value, patients breast Despite existence selective inhibitors current clinical trials, cellular mechanisms are not yet known. present review aims understand state important disease paths that must be forged.

Язык: Английский

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Mitochondrial dynamics as regulators of cancer biology

Cellular and Molecular Life Sciences, Год журнала: 2017, Номер 74(11), С. 1999 - 2017

Опубликована: Янв. 12, 2017

Язык: Английский

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Micropeptide CIP 2A‐ BP encoded by LINC 00665 inhibits triple‐negative breast cancer progression

The EMBO Journal, Год журнала: 2019, Номер 39(1)

Опубликована: Ноя. 22, 2019

Язык: Английский

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Targeting the PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma

Biomedicines, Год журнала: 2021, Номер 9(11), С. 1639 - 1639

Опубликована: Ноя. 8, 2021

Despite advances in the treatment of cancers through surgical procedures and new pharmaceuticals, hepatocellular carcinoma (HCC) remains challenging as reflected by low survival rates. The PI3K/Akt/mTOR pathway is an important signaling mechanism that regulates cell cycle, proliferation, apoptosis, metabolism. Importantly, deregulation leading to activation common HCC hence subject intense investigation focus current therapeutics. In this review article, we consider role pathogenesis HCC, focusing on its downstream effectors such glycogen synthase kinase-3 (GSK-3), cAMP-response element-binding protein (CREB), forkhead box O (FOXO), murine double minute 2 (MDM2), p53, nuclear factor-κB (NF-κB), cellular processes lipogenesis autophagy. addition, provide update ongoing clinical development agents targeting for treatments.

Язык: Английский

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Chemoresistance and the Self-Maintaining Tumor Microenvironment

Cancers, Год журнала: 2018, Номер 10(12), С. 471 - 471

Опубликована: Ноя. 28, 2018

The progression of cancer is associated with alterations in the tumor microenvironment, including changes extracellular matrix (ECM) composition, rigidity, hypervascularization, hypoxia, and paracrine factors. One key malignant phenotype cells their ability to resist chemotherapeutics, elements ECM can promote chemoresistance through a variety signaling pathways, inducing gene expression protein activity that allow resistance. Furthermore, maintained as an environment facilitates chemoresistance, since its constitution modulates cancer-associated cells, which themselves affect microenvironment. In this review, we discuss how properties microenvironment interplay between these external stimuli. We focus on both response environment, well maintenance chemoresistant emerges from complex network present.

Язык: Английский

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Combinatorial Epigenetics Impact of Polyphenols and Phytochemicals in Cancer Prevention and Therapy

International Journal of Molecular Sciences, Год журнала: 2019, Номер 20(18), С. 4567 - 4567

Опубликована: Сен. 14, 2019

Polyphenols are potent micronutrients that can be found in large quantities various food sources and spices. These compounds, also known as phenolics due to their phenolic structure, play a vital nutrient-based role the prevention of diseases such diabetes, cardiovascular diseases, neurodegenerative liver disease, cancers. However, function polyphenols disease therapy depends on dietary consumption biological properties. According American Cancer Society statistics, there will an expected rise 23.6 million new cancer cases by 2030. Due severity increased risk, it is important evaluate preventive measures associated with cancer. Relatively recently, numerous studies have indicated phytochemicals possess properties modifying epigenetic mechanisms modulate gene expression resulting regulation phytochemicals, when administrated dose-dependent combinatorial-based manner, enhanced effect changes, which crucial therapy. Hence, this review focus combined impact modifications DNA methylation histone well non-coding miRNAs for treatment types

Язык: Английский

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Topological Signal Processing Over Simplicial Complexes

IEEE Transactions on Signal Processing, Год журнала: 2020, Номер 68, С. 2992 - 3007

Опубликована: Янв. 1, 2020

The goal of this paper is to establish the fundamental tools analyze signals defined over a topological space, i.e. set points along with neighborhood relations. This setup does not require definition metric and then it especially useful deal non-metric spaces. We focus on simplicial complexes. Graph Signal Processing (GSP) represents special case Topological (TSP), referring situation where are associated only vertices graph. Even though theory can be applied any order, we edges graph show how building complex order two, including triangles, yields benefits in analysis edge signals. After reviewing basic principles algebraic topology, derive sampling for emphasize interplay between different order. Then propose method infer topology from data. conclude applications real discrete vector fields illustrate proposed methodologies.

Язык: Английский

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AGEs, RAGEs and s-RAGE; friend or foe for cancer

Seminars in Cancer Biology, Год журнала: 2017, Номер 49, С. 44 - 55

Опубликована: Июль 14, 2017

Язык: Английский

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