Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 14
Опубликована: Янв. 14, 2025
Atopic dermatitis (AD) is a chronic and inflammatory skin disorder characterized by impaired barrier function imbalanced immunity. Recent advances have revealed that dysbiosis of microbiota plays important roles in the pathogenesis development AD. Meanwhile, endogenous external factors contribute to Additionally, various treatments, including topical phototherapy, systemic biologics, demonstrated positive impacts on clinical outcomes, alongside with modulations cutaneous AD patients. Importantly, therapeutics or products regulating homeostasis potential for treatment early studies. In this review, we underline changes correlated provide an overview regarding its Finally, summarize therapeutic strategies restoring microbial management.
Язык: Английский
Процитировано
2Mitochondria in cutaneous health, disease, ageing and rejuvenation—the 3PM-guided mitochondria-centric dermatology
The EPMA Journal, Год журнала: 2025, Номер unknown
Опубликована: Фев. 14, 2025
Association of both intrinsic and extrinsic risk factors leading to accelerated skin ageing is reflected in excessive ROS production ir/reversible mitochondrial injury burnout, as abundantly demonstrated by accumulating research data. Due the critical role stress pathophysiology disorders, maintained (primary care) restored (secondary health, rejuvenation homoeostasis are considered most effective holistic approach advance dermatological treatments based on systemic health-supportive stimulating measures. Per evidence, an anti-ageing protection, wound healing scarring quality - all strongly depend sustainable functionality well-balanced homoeostasis. The latter can be objectively measured and, if necessary, a manner pre- rehabilitation algorithms tailored individualised patient profiles. entire spectrum corresponding innovations area includes natural rejuvenation, aesthetic reconstructive medicine, protection targeted disorders. Contextually, mitochondria-centric dermatology instrumental for advanced 3PM-guided which makes good use predictive multi-level diagnostics against health-to-disease transition progression relevant Cost-effective new treatment avenues focused health physiologic proposed article including in-depth analysis cases exemplified care with detailed mechanisms expert recommendations presented.
Язык: Английский
Процитировано
2Update on the pathogenesis of atopic dermatitis
Anais Brasileiros de Dermatologia, Год журнала: 2024, Номер 99(6), С. 895 - 915
Опубликована: Авг. 12, 2024
Atopic dermatitis is a chronic, recurrent, and multifactorial skin-mucosal manifestation resulting from the interaction between elements mainly associated with skin barrier deficit, homeostasis of immune response, neurological aspects, patterns reactivity to environmental antigens, which are established in genetically predisposed individuals. In addition skin, atopic diathesis involves other organs such as airways (upper lower), eyes, digestive tract, neuropsychiatric inflict additional morbidity on dermatological patient. The different phenotypes disease fundamentally depend participation each these factors, life circumstances, age groups, occupational exposure patterns, physical activity, pollution, genetic load, climatic factors. A better understanding complexity its pathogenesis allows not only therapeutic targets but also how identify preponderant that mediate activity circumstance, for selecting best treatment strategies mitigation triggering This narrative review presents an update dermatitis, especially aimed at clinical manifestations, main context available strategies.
Язык: Английский
Процитировано
5Regulation of immune responses to food by commensal microbes
Immunological Reviews, Год журнала: 2024, Номер unknown
Опубликована: Сен. 16, 2024
Summary The increasing prevalence of immune‐mediated non‐communicable chronic diseases, such as food allergies, has prompted a deeper investigation into the role gut microbiome in modulating immune responses. Here, we explore complex interactions between commensal microbes and host system, highlighting critical bacteria maintaining homeostasis. We examine how modern lifestyle practices environmental factors have disrupted co‐evolved host–microbe discuss changes composition impact epithelial barrier function, responses to allergens, susceptibility allergic diseases. Finally, potential bioengineered microbiome‐based therapies, live biotherapeutic products, for reestablishing homeostasis prevent or treat allergies.
Язык: Английский
Процитировано
4Biomarkers in Atopic Dermatitis in Children: A Comprehensive Review
Life, Год журнала: 2025, Номер 15(3), С. 375 - 375
Опубликована: Фев. 27, 2025
Atopic dermatitis (AD) is a chronic inflammatory skin disorder with significant implications for patient quality of life and well-documented association the atopic march. Recent advancements in biomarker research have unveiled critical insights into AD pathogenesis, diagnosis, prognosis, therapeutic monitoring. This comprehensive review evaluates utility emerging biomarkers, including cytokines, chemokines, genetic markers, microbiome-related components, understanding disease mechanisms stratifying care. The role minimally invasive diagnostic techniques, such as tape stripping RNA monitoring, highlighted, offering innovative approaches to pediatric populations. Furthermore, this explores biomarkers that predict progression, response, comorbidities, food allergies asthma. Personalized treatment strategies based on endotype-specific are discussed future direction improving clinical outcomes. Despite promising findings, integration routine practice necessitates further validation through large-scale studies. work underscores transformative potential biomarker-driven enhancing management children its associated conditions.
Язык: Английский
Процитировано
0Skin Staphylococcus aureus detection and relationship to atopic dermatitis outcomes using culture and metagenomic sequencing
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Май 21, 2025
Staphylococcus aureus (SA) skin colonization in pediatric atopic dermatitis (AD) increases risk for severe AD and development of other allergic diseases. Despite this, there is no consensus regarding the optimal method to detect SA. Studies comparing metagenomic shotgun sequencing (MSS) culture-based methods SA detection relationships outcomes are lacking. In Mechanisms Progression Atopic Dermatitis Asthma Children (MPAACH) cohort, we defined categories by contact agar plate sampling/culture tape sampling/MSS: double negative, only positive, positive (n = 759). We assessed severity, sensitization, total IgE, across categories. Culture missed 69% samples detected MSS 54% culture. The group exhibited higher sensitization load, serum was more likely develop rhinitis (AR) compared groups. Detection or culture over half method. Importantly, via both correlated with increased AR. Thus, these complementary may be necessary comprehensive evaluation its clinical biologic impact.
Язык: Английский
Процитировано
0Skin Predictive Biomarkers for the Development of Atopic Dermatitis and Food Allergy in Infants
Allergy Asthma and Immunology Research, Год журнала: 2024, Номер 16(4), С. 323 - 323
Опубликована: Янв. 1, 2024
The pathogenesis of atopic dermatitis (AD) is multifactorial, involving a dynamic interplay between genetic susceptibility, skin-barrier dysfunction, microbiome alterations, and immune dysregulation, whereas food allergy (FA) arises from the transcutaneous sensitization to allergens failure in induction oral tolerance. Skin epicutaneous commonly involved development AD FA. Although clinical trials have been conducted prevent or FA by applications emollients on skin after birth, results are not consistent. For more effective preventive strategies, reliable biomarkers required identify high-risk individuals. tape stripping (STS) non-invasive technique for identifying these skin. By analyzing stratum corneum collected via STS, researchers can gain molecular cellular insights into early potential progression This review aims elucidate critical aspects FA, underlying their pathogenesis, manifestations, STS's as tool predictive infants prior onset disease.
Язык: Английский
Процитировано
2Nasal, dermal, oral and indoor dust microbe and their interrelationship in children with allergic rhinitis
BMC Microbiology, Год журнала: 2024, Номер 24(1)
Опубликована: Ноя. 29, 2024
Allergic rhinitis (AR) subjects might have their microenvironment changed due to pathogenesis and living environment. Whether the nasal microbe in AR children differs from healthy how it interplays with dermal, oral indoor dust needs be elucidated. In this case–control study, we analyzed compared bacterial characterization associations nasal, swab samples 62 physician-diagnosed AR(cases) 51 age- gender-matched ones no history of allergic diseases(controls). Full-length 16S rRNA sequencing(swabs) shotgun metagenomics(dust) were applied. Bacterial diversity, composition, abundance difference characteristics fast expectation–maximization for microbial source tracking(FEAST) analysis performed between cases controls. The α-diversity microorganisms was lower than that control group (P = 0.034), β-diversity indices cavity 0.020), skin 0.001) 0.004) significantly different those group. At species levels, a total 10, 15, 12, 15 differentially enriched either or controls oral, samples, respectively(Linear Discriminant Analysis(LDA) score > 2, P < 0.05). Staphylococcus epidermidis single simultaneously more abundant dermal children. By FEAST analysis, 8.85% 10.11% S. came cavity. These proportions higher (2.70% 3.86%) same transfer proportions(P 0.05) observed aureus Classification models by random forest regression at levels showed, dust, had substantial power distinguishing ones, highest (AUC 0.88) followed nasal(AUC 0.81) ones(AUC 0.80). Our study presented enrichment both environment(dust) body sites exposed environment through inhalation(nasal cavity), contact(skin) ingestion(oral cavity) pathways, respectively. Nasal S.epidermidis S.aureus dominant influences on other
Язык: Английский
Процитировано
2An update on the clinical implications of the microbiome in the development of allergy diseases
Allergo Journal International, Год журнала: 2024, Номер 33(7), С. 263 - 268
Опубликована: Авг. 9, 2024
Summary This mini-review is an update on a previous review published in 2021 and aims to summarize recent findings the influence of microbiome allergic diseases. We cover topics food allergy, airway allergies, skin allergies with particular focus clinical implications. Articles between January March 2024 were screened be included this publication.
Язык: Английский
Процитировано
0The Role of Food Allergies (and Testing) in Atopic Dermatitis in Children
Current Dermatology Reports, Год журнала: 2024, Номер unknown
Опубликована: Сен. 30, 2024
Язык: Английский
Процитировано
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