The Effect of Gaseous Ozone Therapy in Conjunction with Periodontal Treatment on Glycated Hemoglobin Level in Subjects with Type 2 Diabetes Mellitus: An Unmasked Randomized Controlled Trial DOI Open Access
Biagio Rapone, Elisabetta Ferrara, Massimo Corsalini

и другие.

International Journal of Environmental Research and Public Health, Год журнала: 2020, Номер 17(15), С. 5467 - 5467

Опубликована: Июль 29, 2020

It is established that inflammation involved in the pathogenesis of Type 2 Diabetes Mellitus (T2DM) by promoting insulin resistance and impaired beta cell function pancreas. Among hypothesized independent risk factors implicated pathogenetic basis disease, periodontal infection has been proposed to promote an amplification magnitude advanced glycation end product (AGE)-mediated upregulation cytokine synthesis secretion. These findings suggest interrelationship between disease type diabetes, describing poor metabolic control subjects with periodontitis as compared nondiabetic more severe T2DM a healthy population, significant positive correlation inflammatory parameters glycated hemoglobin level. Results from clinical trials show treatment able improve glycemic diabetes. Many therapeutic strategies have developed conditions conjunction conventional treatment, among which ozone (O3) specific concern. The principal aim this trial was compare effectiveness intensive intervention consisting gas therapy reducing level diabetic patients standard treatment.This study 12-month unmasked randomized included 100 aged 40-74 years older, diabetes mellitus diagnosed. All received or randomly assigned order (1:1). primary outcome measure at 3, 6, 9 12 months randomization. Secondary outcomes were changes parameters.At months, did not differences than decreasing (HbA1C) lack balance evident.Although change significant, gaseous tended reduce levels hemoglobin. shows benefit traditional treatment.

Язык: Английский

A new classification scheme for periodontal and peri‐implant diseases and conditions – Introduction and key changes from the 1999 classification DOI Open Access
Jack G. Caton,

Gary C. Armitage,

Tord Berglundh

и другие.

Journal Of Clinical Periodontology, Год журнала: 2018, Номер 45(S20)

Опубликована: Июнь 1, 2018

Abstract A classification scheme for periodontal and peri‐implant diseases conditions is necessary clinicians to properly diagnose treat patients as well scientists investigate etiology, pathogenesis, natural history, treatment of the conditions. This paper summarizes proceedings World Workshop on Classification Periodontal Peri‐implant Diseases Conditions. The workshop was co‐sponsored by American Academy Periodontology (AAP) European Federation (EFP) included expert participants from all over world. Planning conference, which held in Chicago November 9 11, 2017, began early 2015. An organizing committee AAP EFP commissioned 19 review papers four consensus reports covering relevant areas periodontology implant dentistry. authors were charged with updating 1999 developing a similar Reviewers workgroups also asked establish pertinent case definitions provide diagnostic criteria aid use new classification. All findings recommendations agreed consensus. introductory presents an overview conditions, along condensed each workgroup sections, but readers are directed thorough discussion rationale, criteria, interpretation proposed Changes highlighted discussed. Although intent base strongest available scientific evidence, lower level evidence opinion inevitably used whenever sufficient research data unavailable. scope this align update current understanding schematic tables briefly highlights changes made It cannot present wealth information reviews, definition papers, that has guided development classification, reference its either management or investigation. Therefore, it strongly recommended reader introduction these subjects. Accessing publication online will allow links view source (Table ).

Язык: Английский

Процитировано

1348

Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions DOI Open Access
Panos N. Papapanou, Mariano Sanz, Nurcan Buduneli

и другие.

Journal Of Clinical Periodontology, Год журнала: 2018, Номер 45(S20)

Опубликована: Июнь 1, 2018

Abstract A new periodontitis classification scheme has been adopted, in which forms of the disease previously recognized as “chronic” or “aggressive” are now grouped under a single category (“periodontitis”) and further characterized based on multi‐dimensional staging grading system. S taging is largely dependent upon severity at presentation well complexity management, while provides supplemental information about biological features including history‐based analysis rate progression; assessment risk for possible poor outcomes treatment; that its treatment may negatively affect general health patient. Necrotizing periodontal diseases, whose characteristic clinical phenotype includes typical (papilla necrosis, bleeding, pain) associated with host immune response impairments, remain distinct category. Endodontic‐periodontal lesions, defined by pathological communication between pulpal tissues given tooth, occur either an acute chronic form, classified according to signs symptoms have direct impact their prognosis treatment. Periodontal abscesses lesions localized accumulation pus within gingival wall pocket/sulcus, rapid tissue destruction systemic dissemination.

Язык: Английский

Процитировано

976

Staging and grading of periodontitis: Framework and proposal of a new classification and case definition DOI Open Access
Maurizio S. Tonetti,

Henry Greenwell,

Kenneth S. Kornman

и другие.

Journal Of Clinical Periodontology, Год журнала: 2018, Номер 45(S20)

Опубликована: Июнь 1, 2018

Abstract Background Authors were assigned the task to develop case definitions for periodontitis in context of 2017 World Workshop on Classification Periodontal and Peri‐Implant Diseases Conditions. The aim this manuscript is review evidence rationale a revision current classification, provide framework definition that fully implicates state‐of‐the‐art knowledge can be adapted as new emerges, suggest system implemented clinical practice, research epidemiologic surveillance. Methods Evidence gathered four commissioned reviews was analyzed interpreted with special emphasis changes regards understanding available prior 1999 classification. systems employed variety chronic diseases identified key criteria classification/case periodontitis. Results discusses merits based Staging Grading proposes framework. Stage I IV defined severity (primarily periodontal breakdown reference root length periodontitis‐associated tooth loss), complexity management (pocket depth, infrabony defects, furcation involvement, hypermobility, masticatory dysfunction) additionally described extent (localized or generalized). Grade estimated direct indirect progression rate three categories: slow, moderate rapid (Grade A‐C). Risk factor analysis used grade modifier. Conclusions paper describes simple matrix stage appropriately define an individual patient. proposed extends beyond description include characterization biological features disease represents first step towards adoption precision medicine concepts It also provides necessary introduction biomarkers diagnosis prognosis.

Язык: Английский

Процитировано

842

Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions DOI Open Access
Søren Jepsen, Jack G. Caton, Jasim M. Albandar

и другие.

Journal Of Clinical Periodontology, Год журнала: 2018, Номер 45(S20)

Опубликована: Июнь 1, 2018

Abstract Background A variety of systemic diseases and conditions can affect the course periodontitis or have a negative impact on periodontal attachment apparatus. Gingival recessions are highly prevalent often associated with hypersensitivity, development caries non‐carious cervical lesions exposed root surface impaired esthetics. Occlusal forces result in injury teeth Several developmental acquired prostheses may predispose to periodontium. The aim this working group was review update 1999 classification regard these conditions, develop case definitions diagnostic considerations. Methods Discussions were informed by four reviews 1) manifestions conditions; 2) mucogingival around natural teeth; 3) traumatic occlusal trauma; 4) dental tooth related factors. This consensus report is based results expert opinion participants. Results Key findings included following: there mainly rare (such as Papillon‐Lefevre Syndrome, leucocyte adhesion deficiency, others) major effect more common diabetes mellitus) variable effects, well affecting apparatus independently plaque biofilm‐induced inflammation neoplastic diseases); diabetes‐associated should not be regarded distinct diagnosis, but recognized an important modifying factor clinical diagnosis descriptor; likewise, tobacco smoking – now considered dependence nicotine chronic relapsing medical disorder adverse effects supporting tissues modifier importance gingival phenotype, encompassing thickness width context novel for introduced; 5) no evidence that lead loss, lesions, recessions; 6) adaptive mobility normal support, whereas they progressive reduced usually requiring splinting; 7) term biologic replaced supracrestal tissue consisting junctional epithelium connective tissue; 8) infringement restorative margins within and/or loss tissue. However, it evident whether periodontium caused biofilm, trauma, toxicity materials combination factors; 9) anatomical factors tissues. Conclusion An updated manifestations apparatus, introduced. Case considerations also presented.

Язык: Английский

Процитировано

491

The association of periodontal diseases with metabolic syndrome and obesity DOI
Søren Jepsen, Jean Suvan, James Deschner

и другие.

Periodontology 2000, Год журнала: 2020, Номер 83(1), С. 125 - 153

Опубликована: Май 8, 2020

Abstract Periodontitis is a multifactorial chronic inflammatory disease associated with dysbiotic plaque biofilms and characterized by progressive destruction of the tooth‐supporting apparatus. Globally, it estimated that 740 million people are affected its severe form. has been suggested to be linked obesity metabolic syndrome. Obesity, defined as excessive fat accumulation, complex disease, high increasing prevalence. Metabolic syndrome cluster obesity, dyslipidemia, hypertension, dysglycemia. periodontitis among most common non‐communicable diseases large body evidence from epidemiologic studies supports association between these conditions. Extensive research established plausible mechanisms explain how conditions can negatively impact each other, pointing bidirectional adverse relationship. At present there only limited available few intervention studies. Nevertheless, global burden combined epidemic important clinical public health implications for dental team. In accordance risk factor approach tackling diseases, proposed oral healthcare professionals have an role in promotion periodontal general well‐being through facilitation healthy lifestyle behaviours.

Язык: Английский

Процитировано

237

Implementation of the new classification of periodontal diseases: Decision‐making algorithms for clinical practice and education DOI
Maurizio S. Tonetti, Mariano Sanz

Journal Of Clinical Periodontology, Год журнала: 2019, Номер 46(4), С. 398 - 405

Опубликована: Март 19, 2019

Implementation of the new classification periodontal diseases requires careful navigation case definitions and organization diagnostic process along rationale easily applicable algorithms. The aim this report was to describe for one such approach designed clinical practice education.The authors developed empiric decision-making algorithms based on effectively discriminate between key diagnoses health, gingivitis periodontitis.A stepwise is proposed that includes (a) a sensitive screening step able suspect periodontitis; (b) specific confirmation provide differential diagnosis periodontitis other conditions characterized by attachment loss; (c) assess severity complexity management (staging); (d) risk profile (grading). Specific are described all steps process.The allows discrimination different health disease. accuracy cost-effectiveness need be validated in prospective trials generalizable operators with level expertise, populations settings.

Язык: Английский

Процитировано

221

Vitamin D Deficiency and Oral Health: A Comprehensive Review DOI Open Access
João Botelho, Vanessa Machado, Luís Proença

и другие.

Nutrients, Год журнала: 2020, Номер 12(5), С. 1471 - 1471

Опубликована: Май 19, 2020

Vitamin D (VD) levels have been gaining growing attention in Oral Health. During growth and adulthood, VD deficiency (VDD) is associated with a wide variety of oral health disorders, impaired synthesis may expedite some these conditions. In children, severe VDD can induce defective tooth mineralization, resulting dentin enamel defects. As consequence, defects increase the risk onset progression dental caries. Further, has higher prevalence periodontitis gingival inflammation, several recent preclinical clinical studies unveiled potential pathways through which interact periodontium. correction supplementation contribute to successful treatment periodontitis; however, alveolar bone regeneration procedures performed baseline patients seem more prone failure. also be linked pathology entities such as certain cancers events osteonecrosis jaw. This review aims provide comprehensive evidence how should considered promote good health, summarize hamper development its role

Язык: Английский

Процитировано

195

Green Alternatives as Antimicrobial Agents in Mitigating Periodontal Diseases: A Narrative Review DOI Creative Commons
Seyed Ali Mosaddad, Ahmed Hussain, Hamid Tebyaniyan

и другие.

Microorganisms, Год журнала: 2023, Номер 11(5), С. 1269 - 1269

Опубликована: Май 11, 2023

Periodontal diseases and dental caries are the most common infectious oral impacting health globally. Oral cavity is crucial for enhancing life quality since it serves as entranceway to general health. The microbiome strongly correlated. Gram-negative anaerobic bacteria have been associated with periodontal diseases. Due shortcomings of several antimicrobial medications frequently applied in dentistry, lack resources developing countries, prevalence inflammatory conditions, rise bacterial antibiotic resistance, there a need reliable, efficient, affordable alternative solutions prevention treatment Several accessible chemical agents can alter microbiota, although these substances also unfavorable symptoms such vomiting, diarrhea, tooth discoloration. Natural phytochemicals generated from plants that historically used medicines categorized prospective alternatives due ongoing quest substitute products. This review concentrated on or herbal extracts impact by decreasing formation biofilms plaques, preventing proliferation pathogens, inhibiting adhesion surfaces. Investigations examining effectiveness safety plant-based presented, including those conducted over past decade.

Язык: Английский

Процитировано

63

Clinical periodontal diagnosis DOI Creative Commons
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber

и другие.

Periodontology 2000, Год журнала: 2023, Номер unknown

Опубликована: Июль 14, 2023

Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In diagnostic process, clinical signs such as bleeding on probing, development periodontal pockets and gingival recessions, furcation involvement radiographic bone loss should be assessed prior therapy, following active during long‐term supportive care. addition, patient‐reported outcomes increased tooth mobility, migration, tilting also considered. More important patient, however, is fact that assessment must followed an appropriate treatment plan. Furthermore, it realized diagnosis based which may not reflect disease but rather represent sequelae previous challenge. Hence, aim present review provide summary criteria required classify patients with health or disease.

Язык: Английский

Процитировано

50

Non–plaque‐induced gingival diseases DOI Open Access
Palle Holmstrup, Jacqueline Plemons, Joerg Meyle

и другие.

Journal Of Clinical Periodontology, Год журнала: 2018, Номер 45(S20)

Опубликована: Июнь 1, 2018

Abstract While plaque‐induced gingivitis is one of the most common human inflammatory diseases, several non–plaque‐induced gingival diseases are less but often major significance for patients. The lesions manifestations systemic conditions, they may also represent pathologic changes limited to tissues. A classification proposed, based on etiology and includes: Genetic/Developmental disorders; Specific infections; Inflammatory immune conditions lesions; Reactive processes; Neoplasms; Endocrine, Nutritional metabolic diseases; Traumatic Gingival pigmentation.

Язык: Английский

Процитировано

115