Emerging issues in probiotic safety: 2023 perspectives

Gut Microbes, Год журнала: 2023, Номер 15(1)

Опубликована: Март 15, 2023

Probiotics are used for both generally healthy consumers and in clinical settings. However, theoretical proven adverse events from probiotic consumption exist. New strains products, as well expanding use of probiotics into vulnerable populations, warrants concise, actionable recommendations on how to work toward their safe effective use. The International Scientific Association Prebiotics convened a meeting discuss produce evidence-based potential acute long-term risks, risks the importance product quality match needs need event reporting related whole genome sequencing, which enables determination virulence, toxin, antibiotic resistance genes, clear assignment species strain identity, is emphasized. We present guide scientific medical community judging safety.

Язык: Английский

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Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome

Signal Transduction and Targeted Therapy, Год журнала: 2019, Номер 4(1)

Опубликована: Окт. 11, 2019

Abstract The trillions of microorganisms in the gut microbiome have attracted much attention recently owing to their sophisticated and widespread impacts on numerous aspects host pathophysiology. Remarkable progress large-scale sequencing mass spectrometry has increased our understanding influence and/or its metabolites onset progression extraintestinal cancers efficacy cancer immunotherapy. Given plasticity microbial composition function, microbial-based therapeutic interventions, including dietary modulation, prebiotics, probiotics, as well fecal transplantation, potentially permit development novel strategies for therapy improve clinical outcomes. Herein, we summarize latest evidence involvement immunity metabolism, effects immune response, modulate microbiome, discuss ongoing studies future areas research that deserve focused efforts.

Язык: Английский

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Metagenomics of Parkinson’s disease implicates the gut microbiome in multiple disease mechanisms

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Ноя. 15, 2022

Abstract Parkinson’s disease (PD) may start in the gut and spread to brain. To investigate role of microbiome, we conducted a large-scale study, at high taxonomic resolution, using uniform standardized methods from end. We enrolled 490 PD 234 control individuals, deep shotgun sequencing fecal DNA, followed by metagenome-wide association studies requiring significance two (ANCOM-BC MaAsLin2) declare association, network analysis identify polymicrobial clusters, functional profiling. Here show that over 30% species, genes pathways tested have altered abundances PD, depicting widespread dysbiosis. PD-associated species form clusters grow or shrink together, some compete. microbiome is permissive, evidenced overabundance pathogens immunogenic components, dysregulated neuroactive signaling, preponderance molecules induce alpha-synuclein pathology, over-production toxicants; with reduction anti-inflammatory neuroprotective factors limiting capacity recover. validate, human findings were observed experimental models; reconcile resolve literature; provide broad foundation wealth concrete testable hypotheses discern PD.

Язык: Английский

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The Microbiome as a Modifier of Neurodegenerative Disease Risk

Cell Host & Microbe, Год журнала: 2020, Номер 28(2), С. 201 - 222

Опубликована: Авг. 1, 2020

Язык: Английский

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Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection

Journal of Advanced Research, Год журнала: 2021, Номер 38, С. 223 - 244

Опубликована: Сен. 17, 2021

Recent research on the implications of gut microbiota brain functions has helped to gather important information relationship between them. Pathogenesis neurological disorders is found be associated with dysregulation gut-brain axis. Some bacteria metabolites are directly increase in reactive oxygen species levels, one most risk factors neurodegeneration. Besides their morbid association, also play a significant role reducing onset these life-threatening disorders.Studies done recent past raises two link and brain: "gut microbiota-oxidative stress-neurodegeneration" microbiota-antioxidant-neuroprotection. This review aims gives deep insight our readers, collective studies done, focusing mediated oxidative stress involved neurodegeneration along focus those showing involvement neuroprotection.This focused three main key concepts. Firstly, mounting evidences from clinical preclinical arenas shows influence resulting dysfunctional processes. Therefore, we describe potential influencing vulnerability stress, budding causative Alzheimer's Parkinson's disease. Secondly, contributing roles been observed attenuating inflammation via its own or by producing secondary and, modulation population antioxidative anti-inflammatory probiotics have shown promising neuro resilience. Thirdly, high throughput silico tools databases correlation microbiome, health, thus providing fascinating perspective new avenues for therapeutic options.

Язык: Английский

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