Decoding dynamic epigenetic landscapes in human oocytes using single-cell multi-omics sequencing

Cell stem cell, Год журнала: 2021, Номер 28(9), С. 1641 - 1656.e7

Опубликована: Май 5, 2021

Язык: Английский

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The role and mechanisms of DNA methylation in the oocyte

Essays in Biochemistry, Год журнала: 2019, Номер 63(6), С. 691 - 705

Опубликована: Ноя. 29, 2019

Abstract Epigenetic information in the mammalian oocyte has potential to be transmitted next generation and influence gene expression; this occurs naturally case of imprinted genes. Therefore, it is important understand how epigenetic patterned during development growth. Here, we review current state knowledge de novo DNA methylation mechanisms oocyte: a distinctive gene-body pattern created, extent which machinery reads chromatin states. Recent epigenomic studies building on advances ultra-low input profiling methods, coupled with genetic studies, have started allow detailed interrogation interplay between establishment states; however, full mechanistic description awaits.

Язык: Английский

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Epigenomic analysis of gastrulation identifies a unique chromatin state for primed pluripotency

Nature Genetics, Год журнала: 2019, Номер 52(1), С. 95 - 105

Опубликована: Дек. 16, 2019

Язык: Английский

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DNA polymerase α interacts with H3-H4 and facilitates the transfer of parental histones to lagging strands

Science Advances, Год журнала: 2020, Номер 6(35)

Опубликована: Авг. 26, 2020

DNA Pol α transfers parental histones to lagging strands.

Язык: Английский

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Rebooting the Epigenomes during Mammalian Early Embryogenesis

Stem Cell Reports, Год журнала: 2020, Номер 15(6), С. 1158 - 1175

Опубликована: Окт. 8, 2020

Язык: Английский

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