International Journal of Antimicrobial Agents, Год журнала: 2023, Номер 61(2), С. 106713 - 106713
Опубликована: Янв. 11, 2023
Язык: Английский
Nature Reviews Genetics, Год журнала: 2023, Номер 25(2), С. 142 - 157
Опубликована: Сен. 25, 2023
Язык: Английский
Процитировано
119
European Journal of Internal Medicine, Год журнала: 2022, Номер 99, С. 7 - 12
Опубликована: Янв. 21, 2022
The incidence of infections caused by bacteria that are resistant to antibiotics is constantly increasing. In Europe alone, it has been estimated each year about 33'000 deaths attributable such infections. One important driver antimicrobial resistance the use and abuse in human medicine. Inappropriate prescribing still very frequent: up 50% all antimicrobials prescribed humans might be unnecessary several studies show at least antibiotic treatments inadequate, depending on setting. Possible strategies optimize everyday clinical practice reduce risk inducing bacterial include: implementation rapid microbiological diagnostics for identification susceptibility testing, inflammation markers guide initiation duration therapies, reduction standard durations courses, individualization therapies dosing considering pharmacokinetics/pharmacodynamics targets, avoiding classes carrying a higher induction resistance. Importantly, measures improve stewardship programs should focus facilitating reasoning improving environment order remove any barriers good prescribing.
Язык: Английский
Процитировано
117
Brazilian Journal of Microbiology, Год журнала: 2021, Номер 53(1), С. 465 - 486
Опубликована: Ноя. 13, 2021
Язык: Английский
Процитировано
116
Applied Catalysis B Environment and Energy, Год журнала: 2023, Номер 325, С. 122401 - 122401
Опубликована: Янв. 17, 2023
Язык: Английский
Процитировано
112
Frontiers in Animal Science, Год журнала: 2021, Номер 2
Опубликована: Май 13, 2021
The rise in the demand for animal products due to demographic and dietary changes has exacerbated difficulties addressing societal concerns related environment, human health, welfare. As a response this challenge, Precision Livestock Farming (PLF) technologies are being developed monitor health welfare parameters continuous automated way, offering opportunity improve productivity detect issues at an early stage. However, ethical have been raised regarding their potential facilitate management of production systems that potentially harmful welfare, or impact human-animal relationship farmers' duty care. Using Five Domains Model (FDM) as framework, aim is explore PLF help address discuss benefits risks using such technology. A variety identified classified according type [sensors, bolus, image sound based, Radio Frequency Identification (RFID)], development stage, species they apply to, on While promising reduce occurrence diseases injuries livestock farming systems, current ability promote positive states remains limited, with generally remain earlier stages. This likely lack evidence validity indicators well challenges technology adoption development. Finally, extent which can be improved will also strongly depend whether practices adapted minimize negative consequences maximize
Язык: Английский
Процитировано
110
Journal of Molecular Liquids, Год журнала: 2022, Номер 352, С. 118725 - 118725
Опубликована: Фев. 12, 2022
Язык: Английский
Процитировано
107
Infection and Drug Resistance, Год журнала: 2022, Номер Volume 15, С. 3589 - 3609
Опубликована: Июль 1, 2022
Although antimicrobials have traditionally been used to treat infections and improve health outcomes, resistance commonly has posed a major challenge. An estimated 700,000 deaths occur globally every year as result of caused by antimicrobial-resistant pathogens. Antimicrobial (AMR) also contributes directly the decline in global economy. In 2019, sub-Saharan Africa (SSA) had highest mortality rate (23.5 per 100,000) attributable AMR compared other regions.We searched PubMed for articles relevant pathogens WHO-GLASS list local importance SSA. this review, we focused on rates surveillance these priority some most encountered public significance. addition, reviewed implementation national action plans mitigate against countries SSA.The SSA region is disproportionately affected AMR, part owing prevailing high levels poverty, which burden infectious diseases, poor regulation antimicrobial use, lack alternatives ineffective antimicrobials. The plan strategy prevention combating adopted countries, but fewer are able fully implement country-specific plans, several challenges exist many settings.A concerted One Health approach will be required ramp up region. addition surveillance, effective infection control, water, sanitation, hygiene, stewardship programs key cost-effective strategies helping tackle AMR.
Язык: Английский
Процитировано
102
Materials Today Bio, Год журнала: 2022, Номер 16, С. 100402 - 100402
Опубликована: Авг. 19, 2022
Язык: Английский
Процитировано
100
Expert Opinion on Drug Safety, Год журнала: 2022, Номер 21(8), С. 1089 - 1111
Опубликована: Июль 23, 2022
Introduction Antimicrobial resistance (AMR) is a concern as this increases morbidity, mortality, and costs, with sub-Saharan Africa having the highest rates globally. Concerns rising AMR have resulted in international, Pan-African, country activities including development of national action plans (NAPs). However, there variable implementation across key challenges persisting.Areas covered Consequently, an urgent need to document current NAP provide future guidance. This builds on narrative review literature.Expert Opinion All surveyed African countries developed their NAPs; however, implementation. Countries Botswana Namibia are yet officially launch NAPs Eswatini only recently launching its NAP. Cameroon further ahead than these countries; though concerns South appears made greatest strides implementing regular monitoring instigation antimicrobial stewardship programs. Key remain Africa. These include available personnel, expertise, capacity, resources undertake agreed active surveillance, lack focal points drive NAPs, competing demands priorities among donors. being addressed, co-ordinated efforts needed reduce AMR.
Язык: Английский
Процитировано
89
Life, Год журнала: 2023, Номер 13(2), С. 317 - 317
Опубликована: Янв. 23, 2023
The skin serves as the body's first line of defense, guarding against mechanical, chemical, and thermal damage to interior organs. It includes a highly developed immune response that barrier pathogenic infections. Wound healing is dynamic process underpinned by numerous cellular activities, including homeostasis, inflammation, proliferation, remodeling, require proper harmonious integration effectively repair damaged tissue. Following cutaneous damage, microorganisms can quickly enter tissues beneath skin, which result in chronic wounds fatal Natural phytomedicines possess considerable pharmacological properties have been widely employed forwound treatment infection prevention. Since ancient times, phytotherapy has able efficiently treat wounds, reduce onset infections, minimize usage antibiotics cause critical antibiotic resistance. There are remarkable number wound-healing botanicals used Northern Hemisphere, Achiella millefolium, Aloe vera, Althaea officinalis, Calendula Matricaria chamomilla, Curcuma longa, Eucalyptus, Jojoba, plantain, pine, green tea, pomegranate, Inula. This review addresses most often medicinal plants from Hemisphere facilitate also suggests viable natural alternatives be field wound care.
Язык: Английский
Процитировано
84