A Hiplot‐based web service for cold atmospheric plasma high‐throughput data integration and analysis on breast cancer DOI Creative Commons
Xiaofeng Dai, Mingjie Wang, Yang Liu

и другие.

iMeta, Год журнала: 2025, Номер unknown

Опубликована: Май 25, 2025

Abstract Incremental evidence on the effect of cold atmospheric plasma (CAP) in specifically killing transformed cells and advances sequencing technologies at multiple omics have led to demand in‐depth exploration mechanisms action driving potency CAP against cancer molecular level. However, high‐throughput data detailing is lacking, let alone corresponding database analytical tool. Here, we sequenced whole transcriptome, proteome, phosphorylome, acetylome, lactylome response using breast as disease model; advanced our previously developed Hiplot platform by establishing a focus‐driven tumor‐specific module, namely medicine (CAPmed‐BC) ( https://capbc.hiplot.com.cn ). CAPmed‐BC first multi‐omics resource for analyzing treatment CAP. It can analyze each type regarding differentially expressed biomarkers, expression landscape, gene ontology analysis, pathway interpretation, set enrichment protein‐protein interaction network. also interrogate dynamic fluctuation, functional activity, metabolic vulnerability combinatorially carefully defined dimensions. We built visualization module support users producing personalized graphs via adjusting parameters. believe that will become valuable characterizing outcome cancers levels, make considerable contributions both oncology.

Язык: Английский

A Hiplot‐based web service for cold atmospheric plasma high‐throughput data integration and analysis on breast cancer DOI Creative Commons
Xiaofeng Dai, Mingjie Wang, Yang Liu

и другие.

iMeta, Год журнала: 2025, Номер unknown

Опубликована: Май 25, 2025

Abstract Incremental evidence on the effect of cold atmospheric plasma (CAP) in specifically killing transformed cells and advances sequencing technologies at multiple omics have led to demand in‐depth exploration mechanisms action driving potency CAP against cancer molecular level. However, high‐throughput data detailing is lacking, let alone corresponding database analytical tool. Here, we sequenced whole transcriptome, proteome, phosphorylome, acetylome, lactylome response using breast as disease model; advanced our previously developed Hiplot platform by establishing a focus‐driven tumor‐specific module, namely medicine (CAPmed‐BC) ( https://capbc.hiplot.com.cn ). CAPmed‐BC first multi‐omics resource for analyzing treatment CAP. It can analyze each type regarding differentially expressed biomarkers, expression landscape, gene ontology analysis, pathway interpretation, set enrichment protein‐protein interaction network. also interrogate dynamic fluctuation, functional activity, metabolic vulnerability combinatorially carefully defined dimensions. We built visualization module support users producing personalized graphs via adjusting parameters. believe that will become valuable characterizing outcome cancers levels, make considerable contributions both oncology.

Язык: Английский

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