Abstract
GO/noGO
tasks
enable
assessing
decision-making
processes
and
the
ability
to
suppress
a
specific
action
according
context.
Here,
rats
had
discriminate
between
2
visual
stimuli
(GO
or
noGO)
shown
on
an
iPad
screen.
The
execution
(for
GO)
nonexecution
of
selected
(to
touch
not
display)
were
reinforced
with
food.
main
goal
was
record
analyze
local
field
potentials
collected
from
cortical
subcortical
structures
when
screen
during
subsequent
activities.
Rats
implanted
recording
electrodes
in
prelimbic
cortex,
primary
motor
nucleus
accumbens
septi,
basolateral
amygdala,
dorsolateral
dorsomedial
striatum,
hippocampal
CA1,
mediodorsal
thalamic
nucleus.
Spectral
analyses
data
demonstrate
that
cortex
selectively
involved
cognitive
motivational
processing
learning
task
but
reward-directed
behaviors.
In
addition,
other
recorded
presented
tendencies
be
these
types
brain
activity
response
presentation
GO
noGO
stimuli.
analyses,
spectrograms,
coherence
areas
indicate
their
involvement
vs.
tasks.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 21, 2024
Abstract
To
determine
whether
the
contributions
of
striatal
projection
neurons
from
direct
(dSPNs)
and
indirect
(iSPNs)
pathways
basal
ganglia
to
action
selection
locomotion
can
be
generalized
across
associative
(DMS)
sensorimotor
(DLS)
striatum
we
compared
optogenetic
activation
or
inhibition
these
on
different
tests.
We
show
that
self-modulation
dSPNs
iSPNs
in
either
compartment
has
opposite
real-time
place
preference,
selecting
an
DMS
but
not
DLS.
During
reward
seeking
displacements,
pathway
both
compartments,
slows
movement.
spontaneous
showed
opposing
effects
depending
modulated.
Remarkably,
DLS
decreases
while
only
facilitates
displacements.
These
findings
support
a
model
opposite,
complementary
undescribed
context.
The
putamen
is
believed
to
receive
value
information
from
the
ventral
striatum
caudate
and
then
for
generation
of
habitual
actions.
However,
it
a
question
what
neurons
process
whether
receives
serially
processed
through
striatal
structures.
We
found
that
in
primate
putamen,
caudate,
selectively
encoded
flexibly
updated
values
adaptive
choices
with
similar
learning
speeds,
rather
than
stably
sustained
habit.
In
reversal
learning,
rostral
dynamically
adjusted
their
discrimination
responses
saccades
following
reversals.
Notably,
acquisition
speeds
within
trials
were
similar,
proposing
parallel
update
each
region.
stable
retrieval,
most
did
not
encode
saccades.
Our
findings
suggest
including
involved
processing
cognitive
flexibility.
European Journal of Neuroscience,
Год журнала:
2024,
Номер
60(1), С. 3447 - 3465
Опубликована: Май 26, 2024
Abstract
As
opposed
to
those
requiring
a
single
action
for
reward
acquisition,
tasks
necessitating
sequences
demand
that
animals
learn
elements
and
their
sequential
order
sustain
the
behaviour
until
sequence
is
completed.
With
repeated
learning,
not
only
exhibit
precise
execution
of
these
but
also
demonstrate
enhanced
smoothness
efficiency.
Previous
research
has
demonstrated
midbrain
dopamine
its
major
projection
target,
striatum,
play
crucial
roles
in
processes.
Recent
studies
have
shown
from
substantia
nigra
pars
compacta
(SNc)
ventral
tegmental
area
(VTA)
serve
distinct
functions
learning.
The
contributions
depend
on
striatal
subregions,
namely
ventral,
dorsomedial
dorsolateral
striatum.
Here,
we
reviewed
recent
findings
role
with
focus
rodent
studies.
Abstract
GO/noGO
tasks
enable
assessing
decision-making
processes
and
the
ability
to
suppress
a
specific
action
according
context.
Here,
rats
had
discriminate
between
2
visual
stimuli
(GO
or
noGO)
shown
on
an
iPad
screen.
The
execution
(for
GO)
nonexecution
of
selected
(to
touch
not
display)
were
reinforced
with
food.
main
goal
was
record
analyze
local
field
potentials
collected
from
cortical
subcortical
structures
when
screen
during
subsequent
activities.
Rats
implanted
recording
electrodes
in
prelimbic
cortex,
primary
motor
nucleus
accumbens
septi,
basolateral
amygdala,
dorsolateral
dorsomedial
striatum,
hippocampal
CA1,
mediodorsal
thalamic
nucleus.
Spectral
analyses
data
demonstrate
that
cortex
selectively
involved
cognitive
motivational
processing
learning
task
but
reward-directed
behaviors.
In
addition,
other
recorded
presented
tendencies
be
these
types
brain
activity
response
presentation
GO
noGO
stimuli.
analyses,
spectrograms,
coherence
areas
indicate
their
involvement
vs.
tasks.
