Effectiveness of Extracellular Vesicle Application in Skin Aging Treatment and Regeneration: Do We Have Enough Evidence from Clinical Trials?
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 2354 - 2354
Опубликована: Март 6, 2025
In
recent
years,
there
has
been
a
dynamic
development
in
therapies
utilizing
extracellular
vesicles
(EVs)
including
exosomes.
Therefore,
we
have
conducted
an
analysis
of
the
scientific
literature
to
verify
current
state
knowledge
about
these
therapies.
A
total
12
clinical
studies
were
analyzed,
covering
use
EVs
treating
skin
aging,
acne
scars,
alopecia,
and
wound
healing.
The
results
indicate
that
exosomes
hold
potential
regenerative
therapies,
offering
innovative
non-invasive
therapeutic
approaches.
At
same
time,
significant
challenges
related
standardization
their
production
lack
large-scale
randomized
identified.
Thus,
also
evaluated
investigated
trials
regard
MISEV
(Minimal
Information
for
Studies
Extracellular
Vesicles)
criteria.
This
review
provides
comprehensive
overview
contemporary
applications
therapy
medicine,
highlighting
directions
further
research.
Язык: Английский
Exosomes in Dermatological Research: Unveiling Their Multifaceted Role in Cellular Communication, Healing, and Disease Modulation
Cosmetics,
Год журнала:
2025,
Номер
12(1), С. 16 - 16
Опубликована: Янв. 22, 2025
Exosomes,
a
subtype
of
extracellular
vehicles
(EVs),
play
pivotal
role
in
cellular
communication
and
have
gained
considerable
attention
dermatological
research.
Formed
through
the
inward
budding
endosomal
membrane,
exosomes
facilitate
transfer
proteins,
lipids,
nucleic
acids,
including
microRNAs
(miRNAs),
thereby
influencing
behavior
function
recipient
cells.
These
vesicles
are
secreted
by
various
cell
types,
keratinocytes,
crucial
for
maintaining
skin
homeostasis,
regulating
immune
responses,
promoting
wound
healing.
Exosomes
demonstrated
therapeutic
potential
addressing
conditions
such
as
hair
disorders,
cancers
photoaging
enhanced
regeneration
reduced
oxidative
stress.
However,
they
also
implicated
disease
progression,
with
pathogens
utilizing
exosome
release
to
evade
host
responses.
Recent
studies
highlight
diverse
origins
functions
exosomes,
suggesting
their
promise
innovative
agents
dermatology.
As
research
continues
elucidate
multifaceted
roles,
represent
frontier
understanding
intercellular
developing
novel
treatments
skin-related
diseases,
underscoring
impact
on
both
health
clinical
applications.
This
review
synthesizes
existing
literature
biology
isolation
focus
implications
contexts.
Язык: Английский
The Role of Mesenchymal Stem Cell-Derived Exosomes in Skin Regeneration, Tissue Repair, and the Regulation of Hair Follicle Growth
Advances in experimental medicine and biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Alopecia Areata: Understanding the Pathophysiology and Advancements in Treatment Modalities
Cureus,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 31, 2025
Alopecia
areata
(AA)
is
an
autoimmune
condition
that
presents
with
non-scarring
hair
loss
affecting
multiple
patients
worldwide
during
their
lifetime.
It
ranges
from
well-defined
patchy
to
diffuse
total
loss,
impacting
all
hair-bearing
areas
of
the
body.
AA
most
commonly
predominantly
manifests
on
scalp.
The
pathophysiology
complex
and
multi-faceted.
findings
our
review
article
were
consistent
recent
literature,
delineating
autoimmunity,
genetic
susceptibility,
environmental
aspects
be
contributing
factors.
One
main
causes
believed
disruption
in
immune
privilege
follicles.
Multiple
loci
involved
follicle
maturation
process
have
been
linked
development
as
evidenced
by
several
studies.
has
postulated
psychological
stressors,
smoking,
alcohol
consumption,
sleep
disturbances,
gut
microbiota,
drugs
play
a
role
pathogenesis
exacerbating
response
against
clinically
diagnosed
disorder.
Topical,
intra-lesional,
oral
corticosteroids,
topical
minoxidil,
cyclosporine,
other
therapy
are
widely
accepted
first-line
treatment
options,
although
incomplete
remission
relapses
common.
Recently
JAK-2
inhibitors
mesenchymal
stem
cell
exosomes
shown
promising
results,
potentially
treating
severe
refractory
loss.
bidirectional
relationship
symptoms
it
can
lead
social
anxiety
depression,
which
turn
aggravate
Hence,
crucial
implement
holistic
approach
managing
including
systemic
therapies,
counseling,
lifestyle
modifications.
imperative
fully
declinate
pathophysiological
mechanisms
disease
formulate
therapies
future
research
help
clinicians
dermatologists
devise
definitive
guidelines
treat
for
long-term
remission.
Язык: Английский
Exosomes
Advances in Cosmetic Surgery,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Recent Advances in Drug Development for Hair Loss
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(8), С. 3461 - 3461
Опубликована: Апрель 8, 2025
Hair
loss
disorders
pose
a
substantial
global
health
burden,
affecting
millions
of
individuals
and
significantly
impacting
quality
life.
Despite
the
widespread
use
approved
therapeutics
like
minoxidil
finasteride,
their
clinical
efficacy
remains
limited.
These
challenges
underscore
pressing
need
for
more
targeted
effective
therapeutic
solutions.
This
review
examines
latest
innovations
in
hair
drug
discovery,
with
focus
on
small-molecule
inhibitors,
biologics,
stem
cell-based
therapies.
By
integrating
insights
from
molecular
mechanisms
leveraging
advancements
research
methods,
development
next-generation
holds
potential
to
transform
management
disorders.
Future
should
prioritize
antibody
therapy
treatments,
as
these
approaches
offer
unprecedented
opportunities
address
limitations
existing
options.
Antibody
therapies
enable
precise
targeting
key
pathways
involved
follicle
regulation,
providing
highly
specific
interventions.
Similarly,
therapies,
including
cell
transplantation
dermal
papilla
regeneration,
directly
regenerative
capacity
follicles,
offering
transformative
restoration.
Язык: Английский