Pharmaceutics,
Год журнала:
2023,
Номер
15(3), С. 898 - 898
Опубликована: Март 10, 2023
Nanomaterials
play
an
increasingly
important
role
in
current
medicinal
practice.
As
one
of
the
most
significant
causes
human
mortality,
and
that
is
increasing
year
by
year,
Alzheimer's
disease
(AD)
has
been
subject
a
very
great
body
research
area
which
nanomedicinal
approaches
show
promise.
Dendrimers
are
class
multivalent
nanomaterials
can
accommodate
wide
range
modifications
enable
them
to
be
used
as
drug
delivery
systems.
By
means
suitable
design,
they
incorporate
multiple
functionalities
transport
across
blood-brain
barrier
subsequently
target
diseased
areas
brain.
In
addition,
number
dendrimers
themselves
often
display
therapeutic
potential
for
AD.
this
review,
various
hypotheses
relating
development
AD
proposed
interventions
involving
dendrimer-base
systems
outlined.
Special
attention
focused
on
more
recent
results
importance
aspects
such
oxidative
stress,
neuroinflammation
mitochondrial
dysfunction
design
new
treatments.
Carbon
dots
(CDs),
comprising
crystalline
graphitized
carbon
cores
and
polymer
surface
groups,
are
currently
attracting
a
lot
of
interest
in
biological
fields
owing
to
their
fluorescent
properties,
high
photostability,
biocompatibility
low
toxicity.
In
addition,
the
easy
preparation
functionalization
CDs
stimulate
development
CDs‐based
composite
materials
with
specific
functions.
Presently,
applications
growing
at
remarkable
speed,
justifying
need
for
up‐to‐date
review
articles
that
capture
recent
progress
this
blossoming
field.
review,
breakthroughs
synthesis,
modification,
optical
toxicology
biocatalytic
platforms
described.
Further,
research
related
bioimaging,
biosensing,
drug
delivery,
antibacterial,
anticancer
(photothermal
therapy,
photodynamic
therapy
synergistic
therapy)
antiviral
therapies
involving
discussed
detail.
Finally,
perspective
on
prospects
challenges
biomedicine
biotechnology
is
provided.
Journal of Nanobiotechnology,
Год журнала:
2022,
Номер
20(1)
Опубликована: Сен. 15, 2022
Besides
the
broad
development
of
nanotechnological
approaches
for
cancer
diagnosis
and
therapy,
currently,
there
is
no
significant
progress
in
treatment
different
types
brain
tumors.
Therapeutic
molecules
crossing
blood-brain
barrier
(BBB)
reaching
an
appropriate
targeting
ability
remain
key
challenges.
Many
invasive
non-invasive
methods,
various
nanocarriers
their
hybrids
have
been
widely
explored
tumor
treatment.
However,
unfortunately,
crucial
clinical
translations
were
observed
to
date.
In
particular,
chemotherapy
surgery
main
methods
therapy
Exploring
mechanisms
BBB
penetration
detail
investigating
advanced
drug
delivery
platforms
are
factors
that
could
bring
us
closer
understanding
effective
against
this
review,
we
discuss
most
relevant
aspects
mechanisms,
observing
both
delivery.
We
also
review
recent
functional
platforms,
from
viruses
cell-based
vehicles,
therapy.
The
destructive
potential
chemotherapeutic
drugs
delivered
considered.
This
then
summarizes
existing
challenges
future
prospects
use
ACS Nano,
Год журнала:
2024,
Номер
18(3), С. 1820 - 1845
Опубликована: Янв. 9, 2024
The
blood–brain
barrier
(BBB)
is
a
specialized
semipermeable
structure
that
highly
regulates
exchanges
between
the
central
nervous
system
parenchyma
and
blood
vessels.
Thus,
BBB
also
prevents
passage
of
various
forms
therapeutic
agents,
nanocarriers,
their
cargos.
Recently,
many
multidisciplinary
studies
focus
on
developing
cargo-loaded
nanoparticles
(NPs)
to
overcome
these
challenges,
which
are
emerging
as
safe
effective
vehicles
in
neurotheranostics.
In
this
Review,
first
we
introduce
anatomical
physiological
functions
BBB.
Second,
present
endogenous
exogenous
transport
mechanisms
by
NPs
cross
We
report
nanomaterials,
carriers,
cargos,
with
detailed
uptake
permeability
characteristics.
Third,
describe
effect
regulating
size,
shape,
charge,
surface
ligands
affect
permeability,
can
be
exploited
enhance
promote
classify
typical
functionalized
nanomaterials
developed
for
crossing.
Fourth,
provide
comprehensive
review
recent
progress
functional
polymeric
applications
multimodal
bioimaging,
therapeutics,
drug
delivery.
Finally,
conclude
discussing
existing
directions,
future
perspectives
employing
Nanomaterials,
Год журнала:
2022,
Номер
12(13), С. 2140 - 2140
Опубликована: Июнь 22, 2022
Neurological
disorders
(NDs)
are
recognized
as
one
of
the
major
health
concerns
globally.
According
to
World
Health
Organization
(WHO),
neurological
main
causes
mortality
worldwide.
include
Alzheimer’s
disease,
Parkinson′s
Huntington′s
Amyotrophic
lateral
sclerosis,
Frontotemporal
dementia,
Prion
Brain
tumor,
Spinal
cord
injury,
and
Stroke.
These
diseases
considered
incurable
because
no
specific
therapies
available
cross
blood-brain
barrier
(BBB)
reach
brain
in
a
significant
amount
for
pharmacological
effect
brain.
There
is
need
development
strategies
that
can
improve
efficacy
drugs
circumvent
BBB.
One
promising
approaches
use
different
types
nano-scale
materials.
nano-based
have
ability
increase
therapeutic
effect,
reduce
toxicity,
exhibit
good
stability,
targeted
delivery,
drug
loading
capacity.
Different
shapes
nanomaterials
been
widely
used
treatment
disorders,
including
quantum
dots,
dendrimers,
metallic
nanoparticles,
polymeric
carbon
nanotubes,
liposomes,
micelles.
nanoparticles
unique
characteristics,
sensitivity,
selectivity,
BBB
when
nano-sized
particles,
imaging
studies
NDs.
In
this
review,
we
briefly
summarized
recent
literature
on
various
their
mechanism
action
disorders.
Pharmaceutics,
Год журнала:
2023,
Номер
15(3), С. 1019 - 1019
Опубликована: Март 22, 2023
Recently,
carbon
dots
(CDs)
have
been
actively
studied
and
reported
for
their
various
properties.
In
particular,
the
specific
characteristics
of
considered
as
a
possible
technique
cancer
diagnosis
therapy.
This
is
also
cutting-edge
technology
that
offers
fresh
ideas
treating
disorders.
Though
are
still
in
infancy
not
yet
shown
value
to
society,
discovery
has
already
resulted
some
noteworthy
advancements.
The
application
CDs
indicates
conversion
natural
imaging.
Photography
using
demonstrated
extraordinary
appropriateness
bio-imaging,
novel
drugs,
delivery
targeted
genes,
bio-sensing,
photodynamic
therapy,
diagnosis.
review
seeks
provide
comprehensive
understanding
CDs,
including
benefits,
characteristics,
applications,
mode
action.
this
overview,
many
CD
design
strategies
will
be
highlighted.
addition,
we
discuss
numerous
studies
on
cytotoxic
testing
demonstrate
safety
CDs.
current
study
address
production
method,
mechanism,
ongoing
research,
Frontiers in Chemistry,
Год журнала:
2023,
Номер
11
Опубликована: Июль 14, 2023
Carbon
dots
(CDs),
which
have
particle
size
of
less
than
10
nm,
are
carbon-based
nanomaterials
that
used
in
a
wide
range
applications
the
area
novel
drug
delivery
cancer,
ocular
diseases,
infectious
and
brain
disorders.
CDs
biocompatible,
eco-friendly,
easy
to
synthesize,
toxic
with
excellent
chemical
inertness,
makes
them
very
good
nanocarrier
system
deliver
multi-functional
drugs
effectively.
A
huge
number
researchers
worldwide
working
on
CDs-based
systems
evaluate
their
versatility
efficacy
field
pharmaceuticals.
As
result,
there
is
tremendous
increase
our
understanding
physicochemical
properties,
diagnostic
aspects
CDs,
consequently
has
led
us
design
develop
theranostic
for
treatment
multiple
In
this
review,
we
aim
summarize
advances
application
as
including
gene
delivery,
vaccine
antiviral
been
carried
out
last
5
years.
Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(19)
Опубликована: Янв. 11, 2024
Abstract
Cancer,
responsible
for
approximately
10
million
lives
annually,
urgently
requires
innovative
treatments,
as
well
solutions
to
mitigate
the
limitations
of
traditional
chemotherapy,
such
long‐term
adverse
side
effects
and
multidrug
resistance.
This
review
focuses
on
Carbon
Dots
(CDs),
an
emergent
class
nanoparticles
(NPs)
with
remarkable
physicochemical
biological
properties,
their
burgeoning
applications
in
bioimaging
nanocarriers
drug
delivery
systems
cancer
treatment.
The
initiates
overview
NPs
nanocarriers,
followed
by
in‐depth
look
into
barriers
that
could
affect
distribution,
from
administration,
intracellular
trafficking.
It
further
explores
CDs′
synthesis,
including
both
bottom‐up
top‐down
approaches,
notable
biocompatibility,
supported
a
selection
vitro,
vivo
,
ex
studies.
Special
attention
is
given
role
bioimaging,
highlighting
optical
properties.
discussion
extends
emerging
significance
carriers,
particularly
doxorubicin
other
anticancer
agents,
underscoring
recent
advancements
challenges
this
field.
Finally,
we
showcase
examples
promising
bioapplications
CDs,
owing
flexible
design.
As
research
CDs
evolves,
envisage
key
challenges,
potential
CD‐based
therapy.
ACS Nano,
Год журнала:
2024,
Номер
18(18), С. 11560 - 11572
Опубликована: Апрель 29, 2024
Second
near-infrared
(NIR-II)
carbon
dots,
with
absorption
or
emission
between
1000
and
1700
nm,
are
gaining
increasing
attention
in
the
biomaterial
field
due
to
their
distinctive
properties,
which
include
straightforward
preparation
processes,
stable
photophysical
characteristics,
excellent
biocompatibility,
low
cost.
As
a
result,
there
is
growing
focus
on
controlled
synthesis
modulation
of
photochemical
properties
NIR-II
aim
further
expand
biomedical
applications,
current
research
hotspot.
This
account
aims
provide
comprehensive
overview
recent
advancements
dots
within
field.
The
review
will
cover
following
topics:
(i)
design,
synthesis,
purification
(ii)
surface
modification
strategies,
(iii)
particularly
domain
cancer
theranostics.
Additionally,
this
addresses
challenges
encountered
by
outline
future
directions
realm
By
exploring
carbon-based
biomaterials,
we
can
anticipate
that
contribution
garner
increased
contribute
development
next-generation
advanced
functional
thereby
offering
enhanced
tools
strategies
