Journal of Nanoparticle Research,
Год журнала:
2024,
Номер
26(8)
Опубликована: Авг. 1, 2024
Abstract
Glioblastoma
(GBM),
the
most
prevalent
primary
brain
tumor
in
adults,
remains
highly
challenging
due
to
its
invasive
nature,
limited
treatment
effectiveness,
and
short
median
survival
durations.
Standard
of
care
includes
surgery,
radiation,
chemotherapy,
treating
fields;
however,
there
has
been
little
improvement
rates.
Biomimetic
nanoparticles
(NPs),
coated
with
cell
membranes
endogenous
components,
have
immense
potential
for
improving
chemotherapy
GBM,
by
imitating
cellular
architecture
eluding
immune
clearance.
With
more
individualized
efficient
drug
delivery,
immunotherapeutic
approaches
biomimetic
NPs
may
increase
patient
This
article
summarizes
main
research
on
GBM
therapy,
focusing
classification,
mechanisms,
advantages,
challenges,
along
advancements
development
vaccines.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 6, 2025
Synthetic
biology
and
nanotechnology
fusion
represent
a
transformative
approach
promoting
fundamental
clinical
biomedical
science
development.
In
SynBioNanoDesign,
biological
systems
are
reimagined
as
dynamic
programmable
materials
to
yield
engineered
nanomaterials
with
emerging
specific
functionalities.
This
review
elucidates
comprehensive
examination
of
synthetic
biology's
pivotal
role
in
advancing
for
targeted
drug
delivery
systems.
It
begins
exploring
the
synergy
between
nanotechnology,
then
highlights
current
landscape
applications.
Subsequently,
discusses
design
novel
informed
by
principles,
focusing
on
expounding
tools
potential
developing
advanced
nanomaterials.
Afterward,
research
advances
innovative
through
were
systematically
summarized,
emphasizing
integration
genetic
circuitry
program
nanomaterial
responses.
Furthermore,
challenges,
weaknesses
opportunities,
prospective
directions,
ethical
societal
implications
SynBioNanoDesign
elucidated.
Finally,
summarizes
impact
that
may
have
drug-delivery
technologies
future.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2025,
Номер
17(2)
Опубликована: Март 1, 2025
ABSTRACT
The
field
of
nanomedicine
offers
revolutionary
potential
to
reshape
the
discovery
and
development
therapeutics
for
diverse
human
diseases.
However,
its
application
has
been
limited
in
improving
Substance
Use
Disorders
(SUDs),
which
represent
a
profound
public
health
crisis,
including
major
types
such
as
opioid,
alcohol,
stimulant,
cannabis
use
disorders.
Pharmacotherapy,
cornerstone
SUD
management,
reduced
morbidity,
mortality,
societal
impact
addiction,
though
efficacy
ranged
from
none
moderate.
Thus,
there
is
unmet
need
transform
pharmacotherapy
curb
epidemic
addiction.
This
article
explores
roles
nanomedicine‐inspired
precision‐targeted
drug
delivery,
sustained
release,
combination
therapies
increase
therapeutic
minimize
side
effects.
Additionally,
it
discusses
innovative
mechanisms
that
align
with
neurobiological
complexities
addiction
synergistic
approaches
integrate
behavioral
interventions,
device‐based
therapies,
emerging
modalities
immunotherapy
neurostimulation.
Despite
these
advancements,
barriers
treatment
accessibility,
adherence
challenges,
inequitable
resource
distribution
persist,
particularly
underserved
populations.
By
harnessing
transformative
capabilities
integrating
into
holistic,
equitable,
personalized
care
frameworks,
this
review
highlights
path
forward
revolutionize
landscape.
underscores
continued
nano‐SUD
research
strategies
alleviate
substantial
burden
on
individuals,
families,
society.
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 15, 2025
Cancer
immunotherapy
aims
to
harness
the
body's
own
immune
system
for
effective
and
long-lasting
elimination
of
malignant
neoplastic
tissues.
Owing
advance
in
understanding
cancer
pathology
immunology,
many
novel
strategies
enhancing
immunological
responses
against
various
cancers
have
been
successfully
developed,
some
translated
into
excellent
clinical
outcomes.
As
one
promising
strategy
next
generation
immunotherapies,
activating
multi-cellular
network
(MCN)
within
tumor
microenvironment
(TME)
deploy
multiple
mechanisms
action
(MOAs)
has
attracted
significant
attention.
To
achieve
this
effectively
safely,
delivering
or
pleiotropic
therapeutic
cargoes
targeted
sites
cancerous
tissues,
cells,
intracellular
organelles
is
critical,
which
numerous
nanocarriers
developed
leveraged.
In
review,
we
first
introduce
payloads
categorized
according
their
predicted
functions
physicochemical
structures
forms.
Then,
nanocarriers,
along
with
unique
characteristics,
properties,
advantages,
limitations,
are
introduced
notable
recent
applications
immunotherapy.
Following
discussions
on
targeting
strategies,
a
summary
each
nanocarrier
matching
suitable
provided
comprehensive
background
information
designing
regimens.
Bioengineering,
Год журнала:
2025,
Номер
12(4), С. 430 - 430
Опубликована: Апрель 19, 2025
Doxorubicin
(DOX)
is
one
of
the
most
powerful
chemotherapy
drugs
used
to
treat
different
kinds
cancer.
However,
its
usage
has
been
limited
by
typical
side
effects
and
drug
resistance,
particularly
cardiotoxicity.
According
studies,
a
more
effective
promising
method
conjugate
it
or
entrap
in
biocompatible
nanoparticles.
Compared
free
DOX
traditional
formulations,
nanoparticles
using
specific
processes
techniques
can
improve
stability,
minimize
premature
release
at
untargeted
locations,
lower
systemic
toxicity.
This
review
explains
how
various
nanocarriers
target
tumor
therapeutic
efficacy
while
reducing
negative
DOX.
Pharmaceutics,
Год журнала:
2025,
Номер
17(5), С. 640 - 640
Опубликована: Май 12, 2025
The
development
of
effective
vaccines
requires
a
rational
design
that
considers
the
interaction
between
antigens,
their
vectors,
and
immune
system
in
addition
to
activation
pathways
induce
safe
specific
response.
efficacy
vaccine
formulation
depends
on
nature
antigen,
protection
offered
by
delivery
system,
ability
potentiate
response,
precise
release
immunogen.
Carrier
systems
such
as
lipid
nanoparticles,
polymers,
exosomes,
microorganisms
can
be
functionalized
chemical,
physical,
or
biological
methods
generate
selective
improved
biodistribution
profiles.
These
enhance
with
target
cells,
thereby
improving
immunological
efficacy.
conjugation
ligands
modification
parameters
shape,
charge,
size
vectors
specificity,
stability,
efficiency
antigen
transport
cellular
compartments,
facilitating
robust
This
study
examines
modifications
systems,
focusing
biomolecules
physicochemical
changes
presentation.
Additionally,
we
examine
innovative
methods,
including
microneedles,
electroporation,
needle-free
show
potential
for
enhancing
