Seminars in Reproductive Medicine,
Год журнала:
2023,
Номер
41(06), С. 241 - 257
Опубликована: Ноя. 1, 2023
Abstract
In
recent
years,
there
has
been
a
growing
interest
in
identifying
subcellular
causes
of
male
infertility,
and
sperm
DNA
fragmentation
(SDF)
research
at
the
forefront
this
focus.
damage
can
occur
during
spermatogenesis
due
to
faulty
chromatin
compaction
or
excessive
abortive
apoptosis.
It
also
happen
as
transit
through
genital
tract,
often
induced
by
oxidative
stress.
There
are
several
methods
for
SDF
testing,
with
structure
assay,
terminal
deoxynucleotidyl
transferase
d-UTI
nick
end
labeling
(TUNEL)
comet
dispersion
test
being
most
commonly
used.
Numerous
studies
strongly
support
negative
impact
on
fertility
potential.
linked
various
morphological
functional
abnormalities,
ultimately
affecting
natural
conception
assisted
reproductive
technology
outcomes.
This
evidence-based
review
aims
explore
how
influences
reproduction
provide
insights
into
available
therapeutic
options
minimize
its
detrimental
impact.
Clinical Medicine Insights Endocrinology and Diabetes,
Год журнала:
2023,
Номер
16
Опубликована: Янв. 1, 2023
It
is
still
unelucidated
how
hormonal
alterations
affect
developing
organisms
and
their
descendants.
Particularly,
the
effects
of
androgen
levels
are
clinical
relevance
as
they
usually
high
in
women
with
Polycystic
Ovary
Syndrome
(PCOS).
Moreover,
it
unknown
androgens
may
males'
health
Andrology,
Год журнала:
2023,
Номер
12(5), С. 1012 - 1023
Опубликована: Дек. 3, 2023
Chronic
preconception
paternal
alcohol
use
adversely
modifies
the
sperm
epigenome,
inducing
fetoplacental
and
craniofacial
growth
defects
in
offspring
of
exposed
males.
A
crucial
outstanding
question
field
epigenetic
inheritance
concerns
resilience
male
germline
its
capacity
to
recover
correct
sperm-inherited
errors
after
stressor
withdrawal.
Zygote,
Год журнала:
2023,
Номер
unknown, С. 1 - 6
Опубликована: Ноя. 29, 2023
Summary
The
global
transition
towards
diets
high
in
calories
has
contributed
to
2.1
billion
people
becoming
overweight,
or
obese,
which
damages
male
reproduction
and
harms
offspring.
Recently,
more
studies
have
shown
that
paternal
exposure
stress
closely
affects
the
health
of
offspring
an
intergenerational
transgenerational
way.
SET
Domain
Containing
2
(
SETD
),
a
key
epigenetic
gene,
is
highly
conserved
among
species,
crucial
methyltransferase
for
converting
histone
3
lysine
36
dimethylation
(H3K36me2)
into
trimethylation
(H3K36me3),
plays
important
regulator
response
stress.
In
this
study,
we
compared
patterns
SETD2
expression
H3K36me3
pattern
pre-implantation
embryos
derived
from
normal
obese
mice
induced
by
diet.
results
showed
mRNA
was
significantly
higher
high-fat
diet
(HFD)
group
than
control
(CD)
at
2-cell,
4-cell,
8-cell,
16-cell
stages,
morula
blastocyst
stages.
relative
levels
HFD
16-cell,
stage,
stage
were
CD
group.
These
indicated
dietary
changes
parental
generation
(F0)
fed
traceable
2/H3K36me3
embryos,
brings
about
adverse
effects
might
be
related
SETD2/H3K36me3,
throws
new
light
on
effect
obesity
perspective.
Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Июнь 26, 2023
Abstract
Background
:
Genome-wide
DNA
methylation
(DNAme)
profiling
of
the
placenta
with
Illumina
Infinium
Methylation
bead
arrays
is
often
used
to
explore
connections
between
in
utero
exposures,
placental
pathology,
and
fetal
development.
However,
many
technical
biological
factors
can
lead
signals
DNAme
variation
samples
cohorts,
understanding
accounting
for
these
essential
ensure
meaningful
replicable
data
analysis.
Recently,
“epiphenotyping”
approaches
have
been
developed
whereby
be
impute
information
about
phenotypic
variables
such
as
gestational
age,
sex,
cell
composition,
ancestry.
These
epiphenotypes
offer
avenues
compare
across
understand
how
relate
variability.
relationships
epiphenotyping
other
variables,
their
application
downstream
epigenome
analyses,
not
well
studied.
Results
Using
from
204
placentas
three
we
applied
PlaNET
R
package
estimate
ancestry,
composition
samples.
ancestry
estimates
were
highly
correlated
independent
polymorphic
informative
markers,
epigenetic
on
average,
was
estimated
within
4
days
reported
underscoring
accuracy
tools.
Cell
varied
both
but
reassuringly
robust
processing
time.
Interestingly,
ratio
cytotrophoblast
syncytiotrophoblast
proportion
decreased
increasing
differed
slightly
by
maternal
ethnicity
(lower
white
vs.
non-white)
genetic
higher
probability
European
ancestry).
The
cohort
origin
largest
drivers
this
dataset,
based
associations
first
principal
component.
Conclusions
This
work
confirms
that
cohort,
array
(technical)
batch,
type
proportion,
self-reported
ethnicity,
sex
are
important
consider
any
analyses
data.
Further,
demonstrate
estimating
epiphenotype
itself,
when
possible,
provides
an
check
clinically-obtained
provide
a
approach
different
datasets.
Frontiers in Behavioral Neuroscience,
Год журнала:
2024,
Номер
17
Опубликована: Янв. 4, 2024
Introduction
This
study
examined
(1)
whether
measures
of
paternal
anxious
and
depressive
symptoms
collected
prenatally
during
a
follow-up
assessment
when
the
child
was
in
middle
childhood,
predict
neuroendocrine
outcomes,
(2)
outcomes
are
intermediate
factors
between
mental
health
cognitive/behavioral
outcomes.
Middle
childhood
coincides
with
increased
autonomy
as
transitions
into
grade
school,
adrenarche,
maturing
adrenal
gland
increases
secretion
dehydroepiandrosterone
(DHEA)
its
sulfated
metabolite
(DHEA-S),
hormones
that
implicated
corticolimbic
development
which
regulate
emotions
cognition.
Methods
Participants
were
recruited
from
subsample
large
prospective
birth
cohort
(3D
study).
We
conducted
children
6–8
years
old
(
N
=
61
families,
36
boys,
25
girls).
Parental
anxiety,
stress
depression
assessed
via
validated
self-report
questionnaires:
using
an
in-house
anxiety
questionnaire,
Perceived
Stress
Scale
(PSS)
Center
for
Epidemiologic
Studies
Depression
(CES-D),
at
follow
up,
Beck
Anxiety
Inventories.
Children
provided
salivary
hormone
samples,
their
pituitary
volume
measured
structural
Magnetic
Resonance
Imaging
(MRI)
scans.
Child
behaviors
Strengths
Difficulties
Questionnaire
cognitive
WISC-V.
Multiple
regression
analyses
used
to
test
associated
adjusting
maternal
sex.
Indirect-effect
models
important
intermediates
link
Results
Fathers’
prenatal
predicted
lower
DHEA
levels
children,
but
not
volume.
Higher
higher
internalizing
indirect
pathway
DHEA.
No
associations
detected
sex
differences
on
any
measure.
Conclusion
These
results
highlight
often-overlooked
role
pregnancy
development,
suggesting
function
turn
manifest
least
up
childhood.
<p><strong>Alcohol
is
the
most
harmful
drug
of
abuse,
making
alcoholism
a
major
economic
and
public
health
crisis.
Unsurprisingly,
this
has
led
to
majority
neurobiological
research
on
alcohol
focussing
its
direct
effects
an
individual.
This
includes
those
affected
by
foetal
spectrum
disorders
(FASDs).
However,
shown
that
heavy
paternal
drinking
predicts
earlier
heavier
adolescent
in
offspring,
accompanied
with
other
behavioural
molecular
changes.
While
use
disorder
(AUD)
highly
heritable,
genetic
variants
alone
does
not
sufficiently
account
for
risk
FASDs
like
symptoms
seen
offspring
alcoholic
fathers.
Recently,
there
been
increase
appreciation
importance
epigenetic
mechanisms
inheritance,
which
transfer
changes
due
parental
experiences
through
germline.
thesis
aimed
assess
both
inter
transgenerational
impacts
preconceptual
consumption
(PPAC)
using
rat
model.
Sprague
Dawley
male
rats
(F0)
underwent
chronic
voluntary
ethanol
intake
at
end
paradigm
were
kept
one
spermatogenesis
cycle
before
being
mated
naïve
females.
The
litters
matched
controls
behaviourally
assessed,
cohort
F1
males
observe
F2
generation.</strong></p><p>PPAC
caused
generations,
including
altering
litter
sizes
delaying
development.
also
show
reduction
sensitivity
motor
impairing
compared
controls.
Sexually
dimorphic
PPAC
female
having
reduced
preference
F2,
while
tolerance
coordination
was
again
females
but
males.
Likewise,
presented
reductions
locomotor
activity
these
did
persist
F2.</p><p>Analysis
liver
mitochondrial
DNA
copy
number
(mtDNA-CN)
found
F0
fathers
had
mtDNA-CN
12
weeks
post-drinking
relative
livers
showed
lower
sired
non-drinkers
after
undergoing
consumption,
suggesting
differences
metabolism.
Finally,
drinkers
expression
Peroxisome
proliferator-activated
receptor
γ
coactivator
1α
(Pgc1a),
relating
biogenesis,
methyl-CpG-binding
protein
2
(Mecp2),
indicating
putative
methylation
signalling,
together
inheritance
xenotoxic
stress.</p><p>The
findings
induces
developmental
delays,
causes
behaviour,
function
sexually
manner.
These
may
be
protective
modify
their
intake.
alterations
demonstrate
potential
far-reaching
consequences
metabolism
substances
extending
beyond
provides
evidence
support
across
generations
PPAC.</p>
