Dual inhibition of MAPK/ERK and BMP signaling induces entorhinal-like identity in mouse ESC-derived pallial progenitors

Stem Cell Reports, Год журнала: 2025, Номер unknown, С. 102387 - 102387

Опубликована: Янв. 1, 2025

The mechanisms that determine distinct embryonic pallial identities remain elusive. central role of Wnt signaling in directing dorsal telencephalic progenitors to the isocortex or hippocampus has been elucidated. Here, we show timely inhibition MAPK/ERK and BMP neuralized mouse stem cells (ESCs) specifies a cell identity characteristic allocortex. Comparison global gene expression profiles neural generated by (MiBi cells) with those from early postnatal encephalic regions reveals MiBi cells, isocortical hippocampal cells. display unique pattern connectivity, share molecular electrophysiological features entorhinal cortex. Our results suggest changes can specify fates are maintained specific neuronal lineages independent subsequent morphogenetic interactions their functional connectivity.

Язык: Английский

Comparison of extracellular Giant Depolarizing Potentials in vitro and Early Sharp Waves in vivo in the CA1 hippocampus of neonatal rats

Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 735, С. 150823 - 150823

Опубликована: Окт. 11, 2024

Язык: Английский